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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide

FcepsilonRIalpha, FCER1A
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IgE, MAST, CAN, HAD, Phosphogluconate Dehydrogenase
Papers on FcepsilonRIalpha
IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity.
Galli et al., Stanford, United States. In J Allergy Clin Immunol, Jan 2016
METHODS: We compared the resistance of RVV-immunized wild-type, IgE-deficient, and Fcer1a-deficient mice after injection of a potentially lethal dose of RVV.
Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.
Shi et al., Zhengzhou, China. In Endocrinology, Nov 2015
IgE receptor FcϵR1-deficient (Fcer1a(-/-)) mice and diet-induced obesity (DIO) mice demonstrated that FcϵR1 deficiency in DIO mice increased food intake, reduced energy expenditure, and increased body weight gain but improved glucose tolerance and glucose-induced insulin secretion.
The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.
Lu et al., Changsha, China. In Clin Rev Allergy Immunol, Oct 2015
Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD, and other mutations associated with epidermal barriers such as SPINK5, FLG-2, SPRR3, and CLDN1 have all been linked to AD. Gene variants may also contribute to the abnormal innate and adaptive responses found in AD, including mutations in PRRs and AMPs, TSLP and TSLPR, IL-1 family cytokines and receptors genes, vitamin D pathway genes, FCER1A, and Th2 and other cytokines genes.
The STAT5-GATA2 pathway is critical in basophil and mast cell differentiation and maintenance.
Huang et al., Wuhan, China. In J Immunol, Jun 2015
We demonstrated that GATA2 was required for maintaining Fcer1a mRNA and FcεRIα protein expression on both basophils and mast cells, as well as for maintaining Kit mRNA and c-Kit protein expression on mast cells.
Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance.
Ferdinandy et al., Szeged, Hungary. In J Cardiovasc Pharmacol, May 2015
Of 7742 genes analyzed by DNA microarray, we found that although the expression of 25 genes changed significantly in the heart (increased: Tas2r119, Map6, Cd59, Kcnh2, Kcnh3, Senp6, Mcpt1, Tshb, Haus1, Vipr1, Lrn3, Lifr; decreased: Ihh, Fgfr1, Cryge, Krt9, Agrn, C4bpb, Fcer1a, Csf3, Hsd17b11, Hsd11b2, Ctnnbl1, Prpg1, Hsf1), only 14 genes were altered in the aorta (increased: Tas2r119, Ihh, Rrad, Npm1, Snai1; decreased: Tubb2b, Usp15, Sema6c, Wfdc2, Rps21, Ramp2, Galr1, Atxn1, Lhx1) in vascular nitrate tolerance.
Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata.
Wunderlich et al., Riyadh, Saudi Arabia. In Parasitol Res, Apr 2015
Berberine downregulates the genes Xaf1, Itgb3bp, and Faim3 involved in apoptotic processes and upregulates genes involved in innate immune responses, as e.g., Colec11, Saa2, Klra8, Clec1b, and Crtam, especially the genes Cpa3, Fcer1a, and Mcpt1, Mcpt2, and Mcpt4 involved in mast cell activity.
Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.
Li et al., Changsha, China. In Arch Dermatol Res, Mar 2015
The present study is to investigate whether FCER1A polymorphisms are associated with the risk of CSU, and to determine whether these polymorphisms influence the therapeutic efficacy of nonsedating H1-antihistamines.
Genetic determinants in the development of sensitization to environmental allergens in early childhood.
Wang et al., Baltimore, United States. In Immun Inflamm Dis, 2014
When analyses were specifically performed for cockroach sensitization, 16 SNPs in 13 genes showed P < 0.05, including five genes with SNPs at P < 0.01 (JAK1, JAK3, IL5RA, FCER1A, and ADAM33).
Nasal sensitization with ragweed pollen induces local-allergic-rhinitis-like symptoms in mice.
Yoshimoto et al., Japan. In Plos One, 2013
Fcer1a(-/-) mice were defective in sneezing but developed normal eosinophilic infiltration.
Modulation of FcεRI-dependent mast cell response by OX40L via Fyn, PI3K, and RhoA.
Pucillo et al., Udine, Italy. In J Allergy Clin Immunol, 2012
OX40L engagement impairs FcepsilonRI activation and Gab2/PI3K/Akt, but not Syk/LAT, phosphorylation
Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1.
Ono et al., London, United Kingdom. In Exp Mol Pathol, 2012
Data show that among expressed chemokines and cytokines, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following FcepsilonRI-CCR1 costimulation.
Current concepts of IgE regulation and impact of genetic determinants.
Kabesch et al., Hannover, Germany. In Clin Exp Allergy, 2012
Linkage and candidate gene studies suggested a number of loci and genes to correlate with total serum IgE levels, and recently genome-wide association studies (GWAS) provided the power to identify genetic determinants for total serum IgE levels: 1q23 (FCER1A), 5q31 (RAD50, IL13, IL4), 12q13 (STAT6), 6p21.3 (HLA-DRB1) and 16p12 (IL4R, IL21R).
Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population.
Li et al., Shanghai, China. In Hum Immunol, 2012
genetic polymorphisms in the promoter region is associated with atopic dermatitis in a Han Chinese population
Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children.
Grayson et al., Milwaukee, United States. In Plos One, 2011
Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children
Identification of cis-acting elements and signaling components of high affinity IgE receptor that regulate the expression of cyclooxygenase-2.
Kim et al., Kwangyang, South Korea. In Cell Physiol Biochem, 2011
results reveal intricate functional interactions among different cis-acting elements of IgE receptor in the transcriptional regulation of cox-2. Fyn-->PI 3-kinase-->Akt pathway directly stimulate
The spectrum of chronic urticaria.
Sheikh et al., Boston, United States. In Allergy Asthma Proc, 2009
autoantibodies against Fcer1a is present in 30-50% urticaria patients
The autoimmune nature of chronic urticaria.
Boguniewicz, Denver, United States. In Allergy Asthma Proc, 2008
More recently, functional IgG autoantibodies against FcepsilonRIalpha and less commonly against IgE have been reported in a subset of patients with CU.
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity.
Romano et al., Vandœuvre-lès-Nancy, France. In Curr Pharm Des, 2007
Pharmacogenetic studies on aspirin hypersensitivity have identified distinct types of predictors, such as HLA genotypes, a polymorphism in the promoter of the FcepsilonRIalpha gene, and variants in genes of enzymes from the arachidonic acid pathway.
A chimeric human-cat fusion protein blocks cat-induced allergy.
Saxon et al., Los Angeles, United States. In Nat Med, 2005
The Fcgamma-Fel d1 protein also blocked in vivo reactivity in FcepsilonRIalpha transgenic mice passively sensitized with human IgE antibody to cat and in Balb/c mice actively sensitized against Fel d1.
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail.
Gros et al., Montréal, Canada. In Nat Genet, 2001
(Mb) Lp interval is delineated proximally by D1Mit113/Apoa2/Fcer1g and distally by Fcer1a/D1Mit149/Spna1 and contains a minimum of 17 transcription units.
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