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F-box protein 10

Fbxo10, PRMT11, F-box protein x
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, V1a, Protein-Arginine N-Methyltransferase, STEP, AP-1
Papers on Fbxo10
FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.
Chun et al., Seoul, South Korea. In Biochem Biophys Res Commun, Oct 2015
PRMT9 (alternatively named FBXO11) and PRMT11 (FBXO10) are expected to have the E3 ubiquitin ligase activity through their F-box domains as well as the methyltrasferase activity.
Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.
Samuelson et al., Louisville, United States. In Mol Carcinog, Feb 2015
Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10).
Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).
Samuelson et al., Louisville, United States. In Mol Carcinog, 2014
Human MCS5A1 breast cancer susceptibility associated SNP rs7042509 is located in F-box protein 10 (FBXO10).
An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a.
Gould et al., Madison, United States. In Nucleic Acids Res, 2012
We identify the downregulation of Fbxo10 expression in T cells as a strong candidate mechanism through which the interacting genetic elements of the resistant Mcs5a allele modulate mammary carcinoma susceptibility.
The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.
Gould et al., Madison, United States. In Breast Cancer Res, 2010
We also found that the two interacting elements of the resistant allele are required for the downregulation of transcript levels of the Fbxo10 gene specifically in T-cells.
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail.
Pan et al., New York City, United States. In Proc Natl Acad Sci U S A, 2008
SCF (Skp1 x CUL1 x F-box protein x ROC1) E3 ubiquitin ligase and Cdc34 E2-conjugating enzyme catalyze polyubiquitination in a precisely regulated fashion.
PRMT11: a new Arabidopsis MBD7 protein partner with arginine methyltransferase activity.
Pitto et al., Pisa, Italy. In Plant J, 2007
Plant methyl-DNA-binding proteins (MBDs), discovered by sequence homology to their animal counterparts, have not been well characterized at the physiological and functional levels.
Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk.
Gould et al., Madison, United States. In Proc Natl Acad Sci U S A, 2007
Mcs5a1 is located within the ubiquitin ligase Fbxo10, whereas Mcs5a2 includes the 5' portion of Frmpd1.
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