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Fascin homolog 1, actin-bundling protein

Fascin, FSCN1
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Actin, CAN, HAD, miR, V1a
Papers using Fascin antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... FascinAbcam ...
ABC of colorectal cancer: treatment of advanced disease
Pignatelli M et al., In British Journal of Cancer, 1999
... Fascin was detected using a mouse monoclonal antibody (Dako-Cytomation, Glostrup, Denmark) as previously ...
Role of fascin in filopodial protrusion
Borisy Gary G. et al., In The Journal of Cell Biology, 1999
... pC-SUPER-Fascin-Tm and -Tc were constructed by replacing EGFP cDNA of pG-SUPER with ECFP cDNA from pECFP-N1 (CLONTECH Laboratories, Inc.) using SacII–NotI ...
Papers on Fascin
Impact of genetic variation on synaptic protein levels in genetically diverse mice.
Spijker et al., Amsterdam, Netherlands. In Proteomics, Feb 2016
Analysis of protein abundance covariation across the 8 strains identified known protein-protein relations (proteins of Arp2/3 complex), as well as novel relations (e.g., Dlg family, Fscn1).
Correlations of fascin-1 and cadherin-17 protein expression with clinicopathologic features and prognosis of patients with gastric cancer.
Cao et al., Shanghai, China. In Tumour Biol, Feb 2016
UNASSIGNED: We aim to explore the associations of fascin-1 and cadherin-17 in gastric cancer (GC) to the clinicopathologic features and prognosis of GC.
The role of FSCN1 in migration and invasion of pituitary adenomas.
Zhang et al., Beijing, China. In Mol Cell Endocrinol, Feb 2016
FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types.
TGF-β1-induced Fascin1 promotes cell invasion and metastasis of human 786-0 renal carcinoma cells.
Chen et al., Davao, Philippines. In Acta Histochem, Jan 2016
The cells were divided into six groups including NT (no transfection), si-NC (transfection with pGenesil-1-con) si-Fascin1 (transfection with pGen-1-FSCN1) groups, and three corresponding groups: NT, si-NC and si-Fascin1 groups treated with TGF-β1.
MicroRNA‑145 inhibits the malignant phenotypes of gastric carcinoma cells via downregulation of fascin 1 expression.
Li et al., Xinxiang, China. In Mol Med Report, Jan 2016
MicroRNA (miR)‑145 has been demonstrated to act as a tumor suppressor, and deregulation of fascin 1 (FSCN1) has been observed in several types of human malignancy, including gastric carcinoma.
A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration.
Parsons et al., Toulouse, France. In J Cell Sci, Jan 2016
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers.
Long noncoding RNA UCA1 promotes bladder cancer cell migration and invasion via hsa-miR-145/ ZEB1/2 /FSCN1 pathway.
Chen et al., Xi'an, China. In Cancer Sci, Dec 2015
Mechanistically, lncRNA-UCA1 induced EMT of bladder cancer cells by upregulating the expression levels of zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), and regulated bladder cancer cell migration and invasion by tumor suppressive hsa-miR-145 and its target gene the actin-binding protein fascin homologue 1 (FSCN1).
Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics.
Cheng et al., New York City, United States. In Spermatogenesis, 2015
A recent report has illustrated the significance of a fascin protein called fascin 1 in actin microfilaments at the ES, pertinent to its role in spermatogenesis (Gungor-Ordueri et al.
Expression of Fascin-1 on human lung cancer and paracarcinoma tissue and its relation to clinicopathological characteristics in patients with lung cancer.
Xing et al., Zhengzhou, China. In Onco Targets Ther, 2014
OBJECTIVE: The objective of the present study was to explore the expression of Fascin-1 in human lung cancer and paracarcinoma tissue, its correlation with clinicopathological characteristics in patients with lung cancer, and study the possible relationship between Fascin-1 expression and clinical-biological behavior of lung cancer.
MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1.
Hong et al., Guangzhou, China. In J Exp Clin Cancer Res, 2014
Fascin homologue 1 (FSCN1) was verified as a direct target of miR-24, and silencing FSCN1 expression with small interfering RNA inhibited NPC cell proliferation and invasion (all P < 0.05).
Juvenile xanthogranulomas of the nervous system: A report of two cases and review of the literature.
Cope-Yokoyama et al., Loma Linda, United States. In Neuropathology, 2013
The pathologic differential diagnosis includes a heterogeneous group of histiocytic proliferations; immunostaining for histiocytic markers CD68, factor XIIIa, and Fascin, and the absence of Birbeck granules and CD1a immunoexpression suggests the diagnosis of JXG.
Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis.
Martin et al., Bristol, United Kingdom. In Bmc Med, 2012
BACKGROUND: Fascin-1 is an actin-bundling protein expressed in many human carcinomas, although absent from most normal epithelia.
Fascin controls neuronal class-specific dendrite arbor morphology.
Tavosanis et al., Martinsried, Germany. In Development, 2012
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
Fascin expression in endocervical neoplasia: correlation with tumour morphology and growth pattern.
Loi et al., Perth, Australia. In J Clin Pathol, 2012
Novel fascin expression occurs during the development and progression of some endocervical neoplasms and may have a role in areas of active tumor invasion.
A novel pathway responsible for lipopolysaccharide-induced translational regulation of TNF-α and IL-6 expression involves protein kinase C and fascin.
Lee et al., Taegu, South Korea. In J Immunol, 2012
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia RAW264.7 macrophages.
Functions of fascin in dendritic cells.
Yamashiro, United States. In Crit Rev Immunol, 2011
Fascin-1 is an actin-bundling protein that shares no homology with other actin-bundling proteins.
E-cadherin and the cytoskeletal network in colorectal cancer development and metastasis.
Pignatelli et al., Bristol, United Kingdom. In Cell Commun Adhes, 2011
The actin-bundling protein Fascin promotes cell motility and is overexpressed in CRC.
Fascin promotes the motility and invasiveness of pancreatic cancer cells.
Chen et al., Beijing, China. In World J Gastroenterol, 2011
Data suggest that fascin promotes pancreatic cancer cell migration, invasion and scattering, thus contributes to the aggressive behavior of pancreatic cancer cells.
Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules.
Adra et al., Riyadh, Saudi Arabia. In Plos One, 2010
High Fascin is associated with breast cancer invasion and metastasis.
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