GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Fas ligand
Fas Ligand, FasL
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
PrP, V1a, CAN, caspase-3, bcl-2
Papers using
Fas Ligand
antibodies
Overexpression of TGF-β1 gene induces cell surface localized Glucose-Regulated Protein 78-associated Latency-associated peptide/TGF-β.
Supplier
In PLoS ONE, 2009
... Anti-FasL (clone MFL3) was from BioLegend.
Lipid rafts, detergent-resistant membranes, and raft targeting signals
Supplier
In Cell Death & Disease, 2005
... clone G247-4 (BD PharMingen, San Diego, CA, USA, referred to as G247 in the manuscript), anti-FasL clone Ab-3 (Calbiochem/Merck Chemicals, Nottingham, UK, referred ...
Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.
Supplier
In PLoS ONE, 2000
... , Fas, p53 and FasL were purchased from BD Biosciences (San Diego, CA); actin ...
Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
Supplier
In The Journal of Cell Biology, 2000
... anti-Fas agonistic antibody CH.11 (Upstate Biotechnology), 1 μg/ml anti-Fas antagonistic antibody ZB4 (Upstate Biotechnology), 5 ng/ml soluble Fas ligand and enhancer (Qbiogene), 25 ng/ml TNF-α (R&D Systems), and 250 ng/ml JO-2 (BD Biosciences).
Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
more suppliersSupplier
In The Journal of Cell Biology, 1997
... Rabbit polyclonal antibodies against Fas (M-20) and against FasL (N-20) and the related control peptides were from Santa Cruz Biotechnology, Inc ...
Papers on
Fas Ligand
A lack of Fas/FasL signalling leads to disturbances in the antiviral response during ectromelia virus infection.
New
Warsaw, Poland. In Arch Virol, Feb 2016
Fas receptor-Fas ligand (FasL) signaling is involved in apoptosis of immune cells and virus-specific cytotoxicity.
Epoxyeicosatrienoic acid analog mitigates kidney injury in a rat model of radiation nephropathy.
New
Milwaukee, United States. In Clin Sci (lond), Feb 2016
Additional studies revealed that captopril or EET-A mitigated renal apoptosis by acting on the p53/Fas/FasL apoptotic pathway.
Characterization and Immunoregulatory Properties of Innate Pro-B-Cell Progenitors.
Review
New
Paris, France. In Methods Mol Biol, Dec 2015
Control of T-cell responses can be achieved by several subsets of B cells with immunoregulatory functions, mostly acting by provision of the anti-inflammatory cytokine IL-10 or exhibiting killing properties through Fas ligand (Fas-L) or granzyme B-induced cell death.
S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer.
Review
New
Dijon, France. In Redox Biol, Dec 2015
In this review, we summarize several examples of protein modification by S-nitrosylation that regulate signaling pathways engaged by members of the TNF superfamily (Fas ligand (FasL), Tumor-necrosis-factor-related apoptosis inducing ligand (TRAIL) and TNFalpha (TNFα)) and the way it influences cell fate decisions.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
New
Nanning, China. In Theriogenology, Dec 2015
Adding BMP1 recombinant protein to the culture medium of the GCs increased the expression of the key cell cycle regulators such as cyclin D1 and cyclin D2 and downregulated the expression of cell apoptosis pathway genes such as Cytochrome C, Fas, FasL, and Chop, both at the mRNA and at the protein levels.
Therapeutic applications of TRAIL receptor agonists in cancer and beyond.
Review
New
São Paulo, Brazil. In Pharmacol Ther, Nov 2015
Similar to TNF and Fas ligand, TRAIL induces apoptosis in caspase-dependent manner following TRAIL death receptor trimerization.
[News in severe clinical adverse drug reactions: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)].
Review
New
Monterrey, Mexico. In Gac Med Mex, Nov 2015
The pathophysiology is incompletely understood; however, current pathogenic models involve Fas ligand, granulysin, and cytokines.
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.
New
Impact
Montréal, Canada. In Immunity, Nov 2015
Instead, the inflammasome-IL-18 pathway impacted maturation of hepatic NK cells, surface expression of the death ligand FasL, and capacity to kill FasL-sensitive tumors.
Effect and Molecular Mechanisms of Traditional Chinese Medicine on Regulating Tumor Immunosuppressive Microenvironment.
Review
Beijing, China. In Biomed Res Int, 2014
Furthermore we summarize the effects and mechanism of TCM on regulating TIM via enhancing antitumor immune responses (e.g., regulating the expression of MHC molecules and Fas/FasL, attenuating cancerigenic ability of cancer stem cells) and remolding immunosuppressive cells (e.g., reversing immune phenotypes of T lymphocytes and tumor associated macrophages, promoting dendritic cells mature, restraining myeloid derived suppressor cells function, and regulating Th1/Th2 factors).
Analysis of functional polymorphisms in apoptosis-related genes in primary open angle glaucoma.
Graz, Austria. In Mol Vis, 2014
Therefore, we investigated the role of four functional apoptosis-related gene variants (Akt1 rs1130233, Bax rs4645878, Fas rs223476, and FasL rs763110) in patients with primary open angle glaucoma.
Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling.
Zhengzhou, China. In Genet Mol Res, 2014
In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure oxygen.
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Impact
Philadelphia, United States. In Nat Med, 2014
We detected selective expression of the death mediator Fas ligand (FasL, also called CD95L) in the vasculature of human and mouse solid tumors but not in normal vasculature.
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.
Impact
Paris, France. In Nat Med, 2014
GDF11 inactivation also corrected the abnormal ratio of immature/mature erythroblasts by inducing apoptosis of immature erythroblasts through the Fas-Fas ligand pathway.
Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.
Impact
Australia. In Nat Med, 2014
Impairment of T cell control results in rapid development of DLBCL-like disease, which can be eradicated by polyclonal CD8(+) T cells in a T cell receptor-, CD28- and Fas ligand-dependent manner.
A type III effector antagonizes death receptor signalling during bacterial gut infection.
Impact
Melbourne, Australia. In Nature, 2013
NleB1 expressed ectopically or injected by the bacterial T3SS prevented Fas ligand or TNF-induced formation of the canonical death-inducing signalling complex (DISC) and proteolytic activation of caspase-8, an essential step in death-receptor-induced apoptosis.
Neutrophil expression of Fas ligand and perforin directs effector CD8 T cell infiltration into antigen-challenged skin.
GeneRIF
Cleveland, United States. In J Immunol, 2012
FasL/perforin-independent functions of hapten-primed CD8 T cells in a contact hypersensitivity model identify new functions for neutrophils in regulating effector CD8 T cell recruitment and immune responses in the skin.
Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts.
GeneRIF
Würzburg, Germany. In J Biol Chem, 2012
Data indicate that oligomerization of CD95L has no major effect on CD95 occupancy.
Seawater induces apoptosis in alveolar epithelial cells via the Fas/FasL-mediated pathway.
GeneRIF
Xi'an, China. In Respir Physiol Neurobiol, 2012
In summary, the Fas/FasL pathway involved in alveolar epithelial cell apoptosis could be important in the pathogenesis of seawater-induced acute lung injury
Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft.
GeneRIF
Changsha, China. In Transplant Proc, 2012
Endothelial cells with expression of FasL or viruses recombinant with FasL gene transfusion can preserve liver function and prolong the survival time of liver allografts.
Schizophrenia is associated with increased levels of serum Fas and FasL.
More papers using
Fas Ligand
antibodies
GeneRIF
Niš, Serbia. In Clin Chem Lab Med, 2012
levels of serum Fas and FasL in schizophrenic patients
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.
Supplier
In PLoS ONE, 1995
... 11R-VIVIT (NFAT inhibitor cell permeable), and the Fas/FasL antagonist, Kp7-6, were from Calbiochem, (Merck KGaA, Darmstadt, Germany) ...
