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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein tyrosine phosphatase, non-receptor type 13

FAP-1, Fas-associated phosphatase-1, PTPN13, PTPL1, PTP-BL, PTP-BAS
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, POLYMERASE, bcl-2
Papers on FAP-1
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL.
Jing et al., Beijing, China. In Oncol Rep, Jan 2016
In OCI-LY1 cell line, gene methylation status, expression of PTPL1 and its reactivation by DNA demethylation was determined by PCR and on the protein level by western blotting.
Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95.
Kukreja et al., Richmond, United States. In Oncotarget, Jan 2016
Sildenafil co-treatment with DOX inhibited DOX-induced NF-κB activity by reducing phosphorylation of IκB and nuclear translocation of the p65 subunit, in addition to down regulation of FAP-1 (Fas associated phosphatase-1, a known inhibitor of CD95-mediated apoptosis) expression.
[Methylation Status of PTPL1 Gene in Non-Hodgkin's Lymphoma Cells].
Jing et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Dec 2015
OBJECTIVE: To investigate the methylation status of PTPL1 in Hut78, Maver, Z138, CA46, Raji and Jurkat cell lines, and the reversing effect of 5-Aza on expression of PTPL1 mRNA.
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.
Ancuta et al., Montréal, Canada. In Retrovirology, 2014
Transcripts significantly enriched in Th17 versus Th1 were previously associated with the regulation of TCR signaling (ZAP-70, Lck, and CD96) and Th17 polarization (RORγt, ARNTL, PTPN13, and RUNX1).
[Expression and Significance of PTPL1 in Hematological Malignancies].
Jing et al., Beijing, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
PTPL1 is a protein with a predicted MW of 270 kD, and plays a major role in many cellular functions, including cell survival, proliferation, differentiation and motility.
Genome Wide Methylome Alterations in Lung Cancer.
Spivack et al., New York City, United States. In Plos One, 2014
IPA analyses showed adenocarcinoma-specific promoter DMxDE overlay identified familiar lung cancer nodes [tP53, Akt] as well as less familiar nodes [HBEGF, NQO1, GRK5, VWF, HPGD, CDH5, CTNNAL1, PTPN13, DACH1, SMAD6, LAMA3, AR].
Protein tyrosine phosphatases as potential therapeutic targets.
Zhang et al., Indianapolis, United States. In Acta Pharmacol Sin, 2014
This review summarizes recent findings on several highly recognized PTP family drug targets, including PTP1B, Src homology phosphotyrosyl phosphatase 2(SHP2), lymphoid-specific tyrosine phosphatase (LYP), CD45, Fas associated phosphatase-1 (FAP-1), striatal enriched tyrosine phosphatases (STEP), mitogen-activated protein kinase/dual-specificity phosphatase 1 (MKP-1), phosphatases of regenerating liver-1 (PRL), low molecular weight PTPs (LMWPTP), and CDC25.
Autophagy chews Fap to promote apoptosis.
Ryan et al., Glasgow, United Kingdom. In Nat Cell Biol, 2014
It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.
Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1.
Thorburn et al., Aurora, United States. In Nat Cell Biol, 2014
We have determined that selective autophagic degradation of the phosphatase Fap-1 promotes Fas apoptosis in Type I cells, which do not require mitochondrial permeabilization for efficient apoptosis.
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade.
Pagano et al., New York City, United States. In Nat Cell Biol, 2013
Purification of the F-box protein FBXL2 identified the PI(3)K regulatory subunit p85β and tyrosine phosphatase PTPL1 as interacting proteins.
Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells.
Sáez et al., Sevilla, Spain. In Clin Exp Metastasis, 2012
The PTPL1 is an important mediator of central cellular processes such as proliferation and invasion.
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
Eklund et al., Chicago, United States. In J Biol Chem, 2012
interaction between Tel and Tel-PdgfRbeta decreases Tel/Icsbp/Hdac3 binding to the PTPN13 cis element, resulting in increased transcription.
Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system.
Kruse et al., Kiel, Germany. In Differentiation, 2012
CD95 signal transduction was not affected by FAP-1 expression in A818-6 monolayer cells; we found a polarisation-induced co-localisation of CD95 and FAP-1.
ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers.
Lee et al., Sioux Falls, United States. In Plos One, 2011
Data show that EphrinB1, a PTPN13 substrate, interacts with ErbB2, and Src kinase mediates EphrinB1 phosphorylation and subsequent MAP Kinase signaling.
Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells.
Lanzi et al., Milano, Italy. In Biochem Pharmacol, 2011
The Ret oncoprotein exerts opposing controls on Fap-1 and CD95, increasing Fap-1 expression and decreasing CD95 cell surface expression.
PTPN13/PTPL1: an important regulator of tumor aggressiveness.
Chalbos et al., Montpellier, France. In Anticancer Agents Med Chem, 2011
REVIEW: the alterations in expression and the genetic and epigenetic arguments supporting an oncogenic or an anti-oncogenic impact of PTPL1
Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer.
Sasiadek et al., Wrocław, Poland. In Acta Biochim Pol, 2010
Mutational analysis of the tyrosine phosphatome in CRCs has identified somatic mutations in PTPRG, PTPRT, PTPN3, PTPN13 and PTPN14.
Structural diversity of PDZ-lipid interactions.
Zimmermann et al., Leuven, Belgium. In Chembiochem, 2010
Using the current knowledge on syntenin-1, syntenin-2, PTP-Bas, PAR-3 and PICK1, we recapitulate our understanding of the structural and biochemical aspects of PDZ-lipid interactions and the consequences for peptide interactions.
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.
Grusby et al., Boston, United States. In Immunity, 2007
We have identified PTP-Basophil like (PTP-BL) as a STAT PTP.
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Velculescu et al., Baltimore, United States. In Science, 2004
A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs (PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and gastric cancers.
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