Ubiquitylation and the Fanconi anemia pathway.
New York City, United States. In Febs Lett, 2011
Early steps in DNA damage dependent activation of the pathway are governed by monoubiquitylation of FANCD2 and FANCI by the intrinsic FA E3 ubiquitin ligase, FANCL.
Regulatory functions of ubiquitin in diverse DNA damage responses.
Toronto, Canada. In Curr Mol Med, 2011
This review will focus on the regulatory functions of ubiquitylation in three distinct DNA damage responses that involve ubiquitin modification of proliferating cell nuclear antigen (PCNA) in DNA damage tolerance, the core histone H2A and its variant H2AX in double strand break repair (DSBR) and the Fanconi anaemia (FA) proteins FANCD2 and FANCI in cross link repair.