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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


FAF1, Fas-associated factor 1, hFAF1
Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, PrP, V1a, Arylamine N-Acetyltransferase, p97
Papers on FAF1
Identification of pathways related to FAF1/H. pylori-associated gastric carcinogenesis through an integrated approach based on iTRAQ quantification and literature review.
Chen et al., Nanning, China. In J Proteomics, Feb 2016
UNLABELLED: Previously we showed that down-regulation of tumor suppressor FAF1 mRNA, potentially caused by H. pylori, correlated with increasing tumor differentiation and distant metastasis in gastric cancer.
VAP (VAMP-Associated Proteins) as Receptors that couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis.
Aridor et al., Pittsburgh, United States. In J Biol Chem, Feb 2016
Using this information, we defined functional and physical interactions between VAPB and proteostasis regulators (ligands), including the UPR sensor ATF6 and the ER degradation cluster that included FAF1, VCP, BAP31 and Derlin-1.
New perspectives on the mutated NGLY1 enigma.
Tickotsky-Moskovitz, Ramat Gan, Israel. In Med Hypotheses, Nov 2015
Network analysis identified FAF1 (Fas-Associated Factor 1), an apoptosis-potentiating protein, as a possible degradation substrate of NGLY1.
Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin.
Ye et al., Dallas, United States. In Cell Rep, Nov 2015
Unsaturated FAs bind to the UAS domain of Fas-associated factor 1 (FAF1), a protein known to bind β-catenin, accelerating its degradation.
SUMO-Enriched Proteome for Drosophila Innate Immune Response.
Ratnaparkhi et al., Pune, India. In G3 (bethesda), Oct 2015
Caspar, a human FAF1 ortholog that negatively regulates immune-deficient signaling, is SUMOylated at K551 and responds to treatment with lipopolysaccharide in cultured cells.
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Lee et al., Suwŏn, South Korea. In Neuroreport, Oct 2015
Our results show that Fas-associated factor 1 (FAF1) expression as well as caspase-3 activation were increased in AT8-positive MS/VDB cholinergic neurons.
HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1.
Qian et al., Beijing, China. In Cell Stress Chaperones, Jul 2015
Fas-associated factor 1 (FAF1) is a member of the Fas death-inducing signaling complex (Fas-DISC) that acts upstream of caspase-8.
Effects of VBMDMP on the reversal of cisplatin resistance in human lung cancer A549/DDP cells.
He et al., Guangzhou, China. In Oncol Rep, 2015
The results demonstrated that rVBMDMP increased the phosphorylation of 79 signaling proteins, including focal adhesion kinase (FAK), caspase-6, Fas, FasL and FAF1 and downregulated 30 signaling proteins, including integrin αV, integrin β3, PI3K/Akt, NF-κB and MRP-2 compared with the controls.
The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes.
Hansen et al., Copenhagen, Denmark. In Plos One, 2014
OBJECTIVES: A trans-ethnic meta-analysis of type 2 diabetes genome-wide association studies has identified seven novel susceptibility variants in or near TMEM154, SSR1/RREB1, FAF1, POU5F1/TCF19, LPP, ARL15 and ABCB9/MPHOSPH9.
Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1.
Weber, Cincinnati, United States. In Sarcoma, 2014
A likely culprit for the disease is the point mutation S181G in FAF1, which may cause a loss of apoptotic function consecutive to transforming DNA damage.
Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast.
Ye et al., Beijing, China. In J Biol Chem, 2014
Krr1 and Faf1 are two interacting proteins present in early 90 S precursor particles of the small ribosomal subunit.
The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer.
Chung et al., Inch'ŏn, South Korea. In Obstet Gynecol Sci, 2014
OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation between FAF1 and HSP70 in ovarian cancer.
VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.
Alexandru et al., Dundee, United Kingdom. In Bmc Biol, 2013
BACKGROUND: FAF1 is a ubiquitin-binding adaptor for the p97 ATPase and belongs to the UBA-UBX family of p97 cofactors.
Aberrantly expressed long noncoding RNAs in human intervertebral disc degeneration: a microarray related study.
Luo et al., In Arthritis Res Ther, 2013
Interestingly, we found that Fas-associated protein factor-1 (FAF1), which potentiates the Fas-mediated apoptosis and its nearby enhancer-like lncRNA RP11-296A18.3,
Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.
ten Dijke et al., Leiden, Netherlands. In J Biol Chem, 2012
Fas-associated factor 1 is a scaffold protein that promotes beta-transducin repeat-containing protein (beta-TrCP)-mediated beta-catenin ubiquitination and degradation.
The NLRP12 pyrin domain: structure, dynamics, and functional insights.
Peti et al., Providence, United States. In J Mol Biol, 2011
The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling.
Crystallization and preliminary X-ray crystallographic analysis of the hexameric human p97/VCP ND1 fragment in complex with the UBX domain of human FAF1.
Yang et al., Seoul, South Korea. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
Wild-type p97/VCP ND1 in complex with FAF1 UBX crystallized into very thin sheet-shaped crystals which turned out to be of poor diffraction quality
Fas-associated factor 1 as a regulator of olfactory axon guidance.
Belluscio et al., Bethesda, United States. In J Neurosci, 2011
In transgenic mice in which FAF1 is expressed in immature olfactory sensory neurons (OSNs), FAF1 not only misroutes OSN axons to deep layers of the olfactory bulb but also disrupts the glomerular layer
Hierarchical binding of cofactors to the AAA ATPase p97.
Schindelin et al., Würzburg, Germany. In Structure, 2011
FAF1 and UBXD7 only bind to p97-UFD1/NPL4, but not free p97, thus demonstrating for the first time a hierarchy in p97-cofactor interactions
FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis.
Testa et al., Philadelphia, United States. In Cell Cycle, 2009
FAS-associated factor 1, FAF1, is an evolutionarily conserved protein that has several protein interaction domains.
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