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Fatty acid desaturase 1

FADS1, Delta5-desaturase, D5D
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, delta-6-desaturase, HAD, CAN, Insulin
Papers on FADS1
Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations.
Lin et al., Shanghai, China. In Hum Mol Genet, Feb 2016
We also confirmed previously reported loci including FADS1, NTAN1, NRBF2, ELOVL2 and GCKR Different effect sizes in FADS1 and independent association signals in ELOVL2 were observed.
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue.
Pihlajamäki et al., Kuopio, Finland. In J Lipid Res, Jan 2016
We demonstrated an association between serum levels of saturated and polyunsaturated n-6 FAs, and estimated enzyme activities of FADS1/2 genes with IL-1β expression in AT both at baseline and at follow-up.
A High-Fat, High-Oleic Diet, But Not a High-Fat, Saturated Diet, Reduces Hepatic α-Linolenic Acid and Eicosapentaenoic Acid Content in Mice.
Murphy et al., Grand Forks, United States. In Lipids, Jan 2016
Expression of Fads1 (Δ5 desaturase) and Fads2 (Δ6 desaturase) was elevated by the high MUFA and reduced by the high SFA diet.
Fatty acid composition of chicken breast meat is dependent on genotype-related variation of FADS1 and FADS2 gene expression and desaturating activity.
Sirri et al., Bologna, Italy. In Animal, Jan 2016
Slow (SG), medium (MG) and fast (FG) growing chickens fed the same diet were evaluated either for the relative expression of FADS1, FADS2 and SCD1 genes in liver (by q-PCR), or for the FA composition of breast meat.
Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration.
den Hollander et al., Nijmegen, Netherlands. In Invest Ophthalmol Vis Sci, Jan 2016
RESULTS: Significant genotypic associations with AMD were observed for SNPs in CETP, APOE, and FADS1.
Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study.
Broberg et al., Coleraine, United Kingdom. In Prostaglandins Leukot Essent Fatty Acids, Dec 2015
These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2).
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Zheng et al., Nashville, United States. In Nat Genet, 2014
Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN).
Unsaturated fatty acids, desaturases, and human health.
Park et al., Ch'ŏnan, South Korea. In J Med Food, 2014
The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain.
Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease.
Martinelli et al., Verona, Italy. In Adv Exp Med Biol, 2013
Delta-5 (D5D) and delta-6 desaturases (D6D), encoded respectively by FADS1 and FADS2 genes, are the rate-limiting enzymes for PUFA conversion and are recognized as main determinants of PUFA levels.
A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids.
Brenna et al., Ithaca, United States. In J Lipid Res, 2012
discovery and function of a novel FADS1 splice variant
Nutritional aspects of epigenetic inheritance.
Hungin et al., Delhi, India. In Can J Physiol Pharmacol, 2012
Recently, polymorphisms of the human Delta-5 (fatty acid desaturase, FADS1) and Delta-6 (FADS2) desaturase genes have been described as being associated with the level of several long-chain n-3 and n-6 polyunsaturated fatty acids (PUFAs) in serum phospholipids.
Interactions between dietary n-3 fatty acids and genetic variants and risk of disease.
Ordovás et al., Valencia, Spain. In Br J Nutr, 2012
Greater consistency was observed in studies that involved the FADS1 and FADS2 locus in the determination of n-3 fatty acid concentrations in biological samples.
Fatty acid desaturase 1 polymorphisms are associated with coronary heart disease in a Chinese population.
Shen et al., Nanjing, China. In Chin Med J (engl), 2012
rs174547 in FADS1 may contribute to the susceptibility of CHD by altering HDL-C and TG levels in Chinese individuals.
Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women.
Mizoue et al., Tokyo, Japan. In Atherosclerosis, 2012
Report relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women.
A case-control study between the gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and coronary artery disease in a Chinese Han population.
Xie et al., Changchun, China. In Prostaglandins Leukot Essent Fatty Acids, 2011
rs174556 in the FADS1 gene is very likely to be associated with coronary artery disease in the Chinese Han population
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children.
LISA study group et al., München, Germany. In Plos One, 2010
Correlation coefficients were estimated to describe fatty acid tracking over 4 years and to assess the influence of FADS variants on tracking.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Barroso et al., Boston, United States. In Nat Genet, 2010
These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1).
A genome-wide perspective of genetic variation in human metabolism.
Suhre et al., München, Germany. In Nat Genet, 2010
For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or solute carriers whose functions match the associating metabolic traits.
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Peltonen et al., Los Angeles, United States. In Nat Genet, 2009
We replicate most previously reported associations for these traits and identify nine new associations, several of which highlight genes with metabolic functions: high-density lipoprotein with NR1H3 (LXRA), low-density lipoprotein with AR and FADS1-FADS2, glucose with MTNR1B, and insulin with PANK1.
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