factor V Leiden
Uncertain thrombophilia markers.
Milano, Italy. In Thromb Haemost, Jan 2016
The main inherited thrombophilias include the plasma deficiencies of the natural anticoagulants antithrombin, protein C and S; the gain-of-function mutations factor V Leiden and prothrombin G20210A; some dysfibrinogenaemias and high plasma levels of coagulation factor VIII.
Endothelial Dysfunction and Altered Coagulation As Mediators of Thromboembolism in Behçet Disease.
Madrid, Spain. In Semin Thromb Hemost, Sep 2015
These factors, together with the increased levels of homocysteine observed in BD patients, induce the endothelial cell expression of adhesion molecules (VCAM-1 and ICAM-1) and tissue factor; the release of cytokines, soluble CD40L (sCD40L), matrix metalloproteinase-9, and blood coagulation factor V; the inhibition of fibrinolysis; the disruption of nitric oxide metabolism; and the increase in platelet reactivity and lipid peroxidation.
Activated protein C resistance assay and factor V Leiden.
Graz, Austria. In N Engl J Med, 2014
The authors suggest that functional testing for activated protein C resistance is cheaper and more clinically relevant than genetic testing to detect a factor V Leiden mutation in identifying persons who are at risk for thromboembolism.