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Spondin 1, extracellular matrix protein

F-spondin, Spon1
promotes cell attachment; may play a role in axon guidance in the spinal cord and peripheral nervous system [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: thrombospondin-1, CAN, V1a, ACID, Mindin
Papers on F-spondin
Characterization of F-spondin in Japanese flounder (Paralichthys olivaceus) and its role in the nervous system development of teleosts.
Qi et al., Qingdao, China. In Gene, Feb 2016
F-spondin was originally isolated from the developing embryonic floor plate of vertebrates, secreting numerous kinds of neuron-related molecules.
Spondin 1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma.
Zhang et al., China. In Biochem Biophys Res Commun, Sep 2015
Spondin 1 (SPON1) is cell adhesion protein that involved in attachment of sensory neuron cells and outgrowth of neurites.
F-spondin inhibits differentiation of clastic precursors via lipoprotein receptor-related protein 8 (LRP8).
Takata et al., Hiroshima, Japan. In J Periodontol, Mar 2015
BACKGROUND: F-spondin, known to be a secreted neuronal glycoprotein, is highly expressed on the tooth root surface.
microRNA-506 regulates proliferation, migration and invasion in hepatocellular carcinoma by targeting F-spondin 1 (SPON1).
Li et al., Zhanjiang, China. In Am J Cancer Res, 2014
In addition, miR-506 binds to the 3'UTR of F-spondin 1(SPON1), and enforced expression of miR-506 decreases accumulation of SPON1.
Influence of vascular endothelial growth factor stimulation and serum deprivation on gene activation patterns of human adipose tissue-derived stromal cells.
Ekblond et al., Copenhagen, Denmark. In Stem Cell Res Ther, 2014
Genes most prominently and significantly upregulated by both conditions were growth factors (IGF1, BMP6, PDGFD, FGF9), adhesion molecule CLSTN2, extracellular matrix-related proteins such as matricellular proteins SMOC2, SPON1 and ADAMTS12, and inhibitors of proliferation (JAG1).
Effects of anaerobic training on paraoxonase-1 enzyme (PON1) activities of high density lipoprotein subgroups and its relationship with PON1-Q192R phenotype.
Aksu et al., In J Atheroscler Thromb, 2014
Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P).
Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent.
Liang et al., Taipei, Taiwan. In Plos One, 2014
The induction of IL-1Ra by CpG-B ODNs was F-spondin dependent.
Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2.
Rebeck et al., Washington, D.C., United States. In J Biol Chem, 2014
ApoER2 and VLDLR bind to extracellular glycoproteins, such as Reelin and F-spondin, which leads to phosphorylation of adaptor proteins and subsequent activation of downstream signaling pathways.
F-spondin deficient mice have a high bone mass phenotype.
Abramson et al., London, Canada. In Plos One, 2013
To address its function in bone and cartilage in vivo, we generated mice that were deficient for the F-spondin gene, Spon1.
3'poly-G-tailed ODNs inhibit F-spondin to induce cell death and neurite retraction in rat embryonic neurons.
Liang et al., Taipei, Taiwan. In Mol Neurobiol, 2012
3'G-oligodeoxyribonucleotides enhance nucleus YB-1 to inhibit F-spondin leading to cell death and neurite retraction of embryonic neuron cells.
F-spondin regulates the differentiation of human cementoblast-like (HCEM) cells via BMP7 expression.
Takata et al., Hiroshima, Japan. In Biochem Biophys Res Commun, 2012
These findings indicate that F-spondin regulates the differentiation of human cementoblast-like cells via BMP7 expression.
F-spondin inhibits migration and differentiation of osteoclastic precursors.
Kihara et al., Hiroshima, Japan. In J Periodontol, 2011
downregulates osteoclast recruitment to the root side of periodontal tissue via low-density lipoprotein receptor-related protein 8 and inhibits differentiation of osteoclastic precursors
The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein.
Lawler et al., United States. In Bmc Struct Biol, 2010
The unique feature of F-spondin FS domain is the presence of three disulfide bonds associated with the N- and C-termini of the domain and a highly conserved N-linked glycosylation site.
Role of mindin in diabetic nephropathy.
Tomino et al., Tokyo, Japan. In Exp Diabetes Res, 2010
Mindin (spondin 2) is a member of the mindin-/F-spondin family of secreted extracellular matrix (ECM) proteins.
F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation.
Teixeira et al., New York City, United States. In J Orthop Res, 2010
F-spondin is expressed in embryonic cartilage, where it has the capacity to enhance chondrocyte terminal differentiation and mineralization.
(111)In-CHX-A''-DTPA-anti-mindin/RG-1 monoclonal antibody 19G9
Leung, Bethesda, United States. In Unknown Journal, 2009
Mindins are members of the mindin/F-spondin family of secreted ECM proteins (4).
Peters'-plus syndrome is a congenital disorder of glycosylation caused by a defect in the beta1,3-glucosyltransferase that modifies thrombospondin type 1 repeats.
Maki et al., Tampere, Finland. In Ann Med, 2008
Some ninety human proteins contain TSRs, but thus far the disaccharide has been demonstrated on only thrombospondin 1, properdin, F-spondin, ADAMTS-13, and ADAMTSL-1.
Functional interactions of APP with the apoE receptor family.
Rebeck et al., Washington, D.C., United States. In J Neurochem, 2008
A number of APP-interacting proteins have been identified: intracellularly, APP interacts with adaptor proteins through its conserved NPXY domain; extracellularly, APP interacts with a component of the extracellular matrix, F-spondin.
Regulated proteolysis of APP and ApoE receptors.
Rebeck et al., Washington, D.C., United States. In Mol Neurobiol, 2008
Binding of APP and apoE receptors to specific extracellular matrix proteins (F-spondin and Reelin) promotes their presence on the cell surface and influences whether they will interact with specific cytoplasmic adaptor proteins.
F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension.
Jessell et al., New York City, United States. In Cell, 1992
One such clone encodes a novel secreted protein, F-spondin, which is expressed at high levels in the floor plate.
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