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Superoxide dismutase 3, extracellular

extracellular superoxide dismutase, EC-SOD, SOD3
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SOD, CAN, HAD, ACID, Ros
Papers on extracellular superoxide dismutase
Expression, subcellular localization, and enzyme activity of a recombinant human extra-cellular superoxide dismutase in tobacco (Nicotiana benthamiana L.).
Kim et al., Seoul, South Korea. In Protein Expr Purif, Mar 2016
Human extracellular superoxide dismutase (hEC-SOD) is an enzyme that scavenges reactive oxygen species (ROS).
Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.
Weinreb et al., Haifa, Israel. In Neurotox Res, Feb 2016
Amyotrophic lateral sclerosis (ALS) is the most common degenerative disease of the motoneuron system, involving various abnormalities, such as mitochondrial dysfunction, oxidative stress, transitional metal accumulation, neuroinflammation, glutamate excitotoxicity, apoptosis, decreased supply of trophic factors, cytoskeletal abnormalities, and extracellular superoxide dismutase (SOD)-1 toxicity.
Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.
Kutala et al., Thanjāvūr, India. In Gene, Feb 2016
Dietary intake of folate appears to confer protection against breast cancer through its modulating effects on ER and PR expression and methylation of EC-SOD and BRCA1.
Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3.
Pennypacker et al., Tampa, United States. In Mol Neurobiol, Feb 2016
The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3).
Extracellular Superoxide Dismutase Deficiency Impairs Wound Healing in Advanced Age by Reducing Neovascularization and Fibroblast Function.
Gurtner et al., Stanford, United States. In Exp Dermatol, Jan 2016
Extracellular superoxide dismutase (ecSOD/ SOD3) is a prime antioxidant enzyme in the extracellular space that eliminates ROS.
Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.
Paris et al., Stockholm, Sweden. In Prostate, Dec 2015
METHODS: We measured plasma levels of carotenoids and genotyped 20 single nucleotide polymorphisms (SNP) in SOD1, SOD2, SOD3, XRCC1, and OGG1 among 559 men with non-metastatic prostate cancer undergoing radical prostatectomy.
Interference with PPARγ in Endothelium Accelerates Angiotensin II-induced Endothelial Dysfunction.
Sigmund et al., United States. In Physiol Genomics, Dec 2015
Superoxide levels, and expression of the pro-oxidant Nox2 gene was elevated, whereas expression of the anti-oxidant genes Catalase and SOD3 decreased in carotid arteries from Ang II-infused E-V290M mice.
Expanding roles of superoxide dismutases in cell regulation and cancer.
Zheng et al., New Brunswick, United States. In Drug Discov Today, Nov 2015
There are three distinct members of this metalloenzyme family in mammals: SOD1 (Cu/ZnSOD), SOD2 (MnSOD) and SOD3 (ecSOD).
Histoplasma capsulatum surmounts obstacles to intracellular pathogenesis.
Rappleye et al., Columbus, United States. In Febs J, Sep 2015
H. capsulatum yeasts counteract phagocyte-produced reactive oxygen by expression of oxidative stress defense enzymes including an extracellular superoxide dismutase and an extracellular catalase.
Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.
Ferdinandy et al., Chieti, Italy. In Int J Cardiol, Aug 2015
Genes critical for signaling pathways in cardioprotection include protectomiRs (e.g., microRNA 125b*), ZAC1 transcription factor, pro-inflammatory genes such as cycloxygenase (COX)-2 and inducible nitric oxide synthase (iNOS), antioxidant enzymes such as hemoxygenase (HO)-1, extracellular and manganese superoxidase dismutases (ec-SOD and Mg-SOD), heat shock proteins (HSPs), growth factors such as insulin like growth factor (IGF)-1 and hepatocyte growth factor (HGF), antiapoptotic proteins such as Bcl-2 and Bcl-xL, pro-apoptotic proteins such as FasL, Bcl-2, Bax, caspase-3 and p53, and proangiogenic genes such as TGFbeta, sphingosine kinase 1 (SPK1), and PI3K-Akt.
Ras Oncogene-Mediated Progressive Silencing of Extracellular Superoxide Dismutase in Tumorigenesis.
Laukkanen et al., Napoli, Italy. In Biomed Res Int, 2014
Extracellular superoxide dismutase (SOD3) is a secreted enzyme that uses superoxide anion as a substrate in a dismutase reaction that results in the formation of hydrogen peroxide.
Clinical relevance of thyroid cell models in redox research.
Laukkanen et al., Napoli, Italy. In Cancer Cell Int, 2014
RESULTS: Based on the current results, rat thyroid PC Cl3, PC PTC1, PC E1A, or FRLT5 cell models can be used to study NOX2, NOX4, SOD2, SOD3, CATALASE, GPX1, GPX2, GPX5, PRDX2, and PRDX3 gene expression and function.
A redox signalling globin is essential for reproduction in Caenorhabditis elegans.
Braeckman et al., Gent, Belgium. In Nat Commun, 2014
In addition, both an intra- and extracellular superoxide dismutase act as key partners of GLB-12 to create a transmembrane redox signal.
Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.
Shimizu et al., Chiba, Japan. In Molecules, 2012
There are three SOD isoforms: SOD1/CuZn-SOD, SOD2/Mn-SOD, and SOD3/EC-SOD.
Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.
Rahman et al., Nāgpur, India. In Curr Med Chem, 2012
This includes specific spin traps like α-phenyl-N-tert-butyl nitrone, a catalytic antioxidant (ECSOD mimetic), porphyrins (AEOL 10150 and AEOL 10113), and a superoxide dismutase mimetic M40419, lipid peroxidation and protein carbonylation blockers/inhibitors, such as edaravone and lazaroids/tirilazad, myeloperoxidase inhibitors, as well as specialized pro-resolving mediators/inflammatory resolving lipid mediators, omega-3 fatty acids, vitamin D, and hydrogen sulfide.
The Ala-9Val (Mn-SOD) and Arg213Gly (EC-SOD) polymorphisms in the pathogenesis of preeclampsia in Romanian women: association with the severity and outcome of preeclampsia.
Stamatian et al., Cluj-Napoca / Kolozsvár, Romania. In J Matern Fetal Neonatal Med, 2012
Higher frequency of both Ala-9Val Mn-SOD and Arg213Gly EC-SOD polymorphisms was found in women with preeclampsia compared to women with normal pregnancies.
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.
Gashev et al., Temple, United States. In Lymphat Res Biol, 2012
Data show that aging is associated with reduction in superoxide dismutase (SOD) Cu/Zn-SOD protein expression and total SOD enzymatic activity in mesenteric lymphatic vessel (MLV).
TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS.
Adachi et al., Gifu, Japan. In Free Radic Res, 2012
results suggest that the expression of Extracellular-superoxide dismutase (EC-SOD)was increased by TPA administration, and it was speculated that the activation of PKC, MEK/ERK and an increase of intracellular ROS were necessary for the induction of EC-SOD in THP-1 cells
Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection.
Berg et al., Fort Worth, United States. In J Immunol, 2012
High levels of ecSOD activity resulted in neutrophils with limited protective capacity, whereas neutrophils from mice lacking ecSOD provided superior protection compared with neutrophils from wild-type mice.
Superoxide dismutase 3 limits collagen-induced arthritis in the absence of phagocyte oxidative burst.
Holmdahl et al., Turku, Finland. In Mediators Inflamm, 2011
the SOD3-mediated anti-inflammatory effect on arthritis and peritonitis operates independently of NOX2 complex derived oxidative burst
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