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Exportin 6

exp-6, exportin 6
Exportins, such as XPO6, recruit cargo in the nucleoplasm in the presence of RAN (MIM 601179)-GTP and form ternary export complexes. These complexes are transported through nuclear pore complexes to the cytoplasm, where GTP is hydrolyzed and the export complex is disassembled.[supplied by OMIM, Apr 2004] (from NCBI)
Top mentioned proteins: EXP, Actin, importin, CAN, SET
Papers on exp-6
Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
Imkamp et al., Hannover, Germany. In Anticancer Res, Oct 2015
RESULTS: The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6).
Analysis of the conformational profiles of fenamates shows route towards novel, higher accuracy, force-fields for pharmaceuticals.
Price et al., London, United Kingdom. In Phys Chem Chem Phys, Apr 2015
Representing the ab initio conformational energy profiles as a cosine series alone is ineffective; however, combining a cos 2ξ term to represent the electronic barrier with an intramolecular atom-atom exp-6 term for all atom pairs separated by three or more bonds (1-4 interactions) provides a very effective representation.
The role of exportin 6 in cytoskeletal-mediated cell death and cell adhesion in human non-small-cell lung carcinoma cells following doxorubicin treatment.
Grzanka et al., Laizhou, China. In Folia Histochem Cytobiol, 2013
In this study, we used siRNA method to investigate the role of exportin 6 in the switching between nuclear and cytoplasmic F-actin pools in H1299 cells treated with no, 1.0 or 2.5 μM doxorubicin.
Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress.
Henderson et al., Westmead, Australia. In Biochim Biophys Acta, 2013
Actin shuttles in and out of the nucleus through the action of transport receptors importin-9 and exportin-6.
Steady-state nuclear actin levels are determined by export competent actin pool.
Vartiainen et al., Helsinki, Finland. In Cytoskeleton (hoboken), 2013
Importin 9 and exportin 6 transport factors are responsible for the continuous nucleocytoplasmic shuttling of actin, but the mechanisms, which result in modulated actin levels, have not been characterized.
Active maintenance of nuclear actin by importin 9 supports transcription.
Vartiainen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, 2012
Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6.
A molecular dynamics study of 1,1-diamino-2,2-dinitroethylene (FOX-7) crystal using a symmetry adapted perturbation theory-based intermolecular force field.
Szalewicz et al., United States. In Phys Chem Chem Phys, 2011
Interaction energies of 1008 dimer configurations were computed in an augmented double zeta basis set and fitted to an atom-atom intermolecular potential energy function of Coulomb plus Buckingham exp-6 form.
Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
Lim et al., Suwŏn, South Korea. In Exp Cell Res, 2011
Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
Freezing of Lennard-Jones-type fluids.
Morfill et al., Garching bei München, Germany. In J Chem Phys, 2011
In this paper, we test this approach using a wide range of the LJ-type potentials, including LJ n-6 and exp-6 models, and find that it remains sufficiently accurate and reliable in reproducing the corresponding freezing curves, down to the triple-point temperatures.
Gaussian charge polarizable interaction potential for carbon dioxide.
Persson, Göteborg, Sweden. In J Chem Phys, 2011
It is based on the modified Buckingham exp-6 potential, an anisotropic Axilrod-Teller correction, and Gaussian charge densities on the atomic sites with an inducible dipole at the center of mass.
Modelling organic crystal structures using distributed multipole and polarizability-based model intermolecular potentials.
Day et al., London, United Kingdom. In Phys Chem Chem Phys, 2010
The program uses a distributed multipole electrostatic model (Q, t = 00,...,44s) for the electrostatic fields, and can use anisotropic atom-atom repulsion models, damped isotropic dispersion up to R(-10), as well as a range of empirically fitted isotropic exp-6 atom-atom models with different definitions of atomic types.
Study of the interaction between short alkanethiols from ab initio calculations.
Busnengo et al., Rosario, Argentina. In Phys Chem Chem Phys, 2010
The derived force field, based on a sum of so-called exp-6 pairwise potentials and effective Coulomb interaction potential between the HS- heads, predicts very well the interaction energies for dimers and trimers of alkanethiols not included in the input database for the fit.
The Use of Anisotropic Potentials in Modeling Water and Free Energies of Hydration.
Galindo et al., Perth, Australia. In J Chem Theory Comput, 2010
The repulsion-dispersion water-water interactions are modeled with a three-site, exp-6 model fitted to the experimental liquid water density and oxygen-oxygen radial distribution function at ambient conditions.
Anomalous melting behavior under extreme conditions: hard matter turning "soft".
Prestipino et al., Messina, Italy. In J Chem Phys, 2009
We show that a system of particles interacting through the exp-6 pair potential, commonly used to describe effective interatomic forces under high compression, exhibits anomalous melting features such as reentrant melting and a rich solid polymorphism, including a stable BC8 crystal.
A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes.
Görlich et al., Heidelberg, Germany. In Nat Cell Biol, 2006
Actin is a major cytoskeletal element and is normally kept cytoplasmic by exportin 6 (Exp6)-driven nuclear export.
Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.
Görlich et al., Lübeck, Germany. In Embo J, 2003
identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes
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