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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

EXO70 Exo70p

Exo70, Exo70p
putative component of the exocyst complex; involved with the docking of exocytotic vesicles with fusion sites on the plasma membrane [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Exo84, Sec5, sec6, Sec8, Sec10
Papers on Exo70
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.
Raikhel et al., Praha, Czech Republic. In Proc Natl Acad Sci U S A, Feb 2016
We discovered that the small molecule Endosidin2 (ES2) binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking.
Analysis of Three-Dimensional Structures of Exocyst Components.
Dong et al., Vienna, Austria. In Methods Mol Biol, Dec 2015
This chapter briefly describes the protocols used in our structure determination of Exo70p and Exo84p, two subunits of the exocyst from Saccharomyces cerevisiae.
EXO70I Is Required for Development of a Sub-domain of the Periarbuscular Membrane during Arbuscular Mycorrhizal Symbiosis.
Harrison et al., Ithaca, United States. In Curr Biol, Sep 2015
The EXOCYST complex is central to this process, and in yeast, regulation of the EXO70 subunit influences exocytosis and cargo specificity.
Membrane targeting of the yeast exocyst complex.
Potocký et al., Praha, Czech Republic. In Biochim Biophys Acta, Jul 2015
In all eukaryotic cells, the exocyst is composed of eight subunits - Sec5, Sec6, Sec8, Sec10, Sec15, Exo84 and two membrane-targeting landmark subunits Sec3 and Exo70, which have been described to directly interact with phosphatidylinositol (4,5)-bisphosphate (PIP2) of the plasma membrane.
Disruption of OsEXO70A1 Causes Irregular Vascular Bundles and Perturbs Mineral Nutrient Assimilation in Rice.
Li et al., Chengdu, China. In Sci Rep, 2014
Expression analysis revealed that mutations in rls2 triggers transcriptional fluctuation of orthologous EXO70 genes and affects genes involved in primary nutrient absorption and transport.
Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p.
Novick et al., San Diego, United States. In J Cell Biol, 2014
Although most exocyst components are brought to these sites by riding on secretory vesicles as they are actively transported along actin cables, Exo70p displays actin-independent localization to these sites, implying an interaction with a polarity determinant.
par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans.
Jäntti et al., Helsinki, Finland. In G3 (bethesda), 2014
We identified seven kinase and seven phosphatase genes that display enhanced phenotypes when combined with hypomorphic alleles of exoc-7 (exo70), exoc-8 (exo84), or an exoc-7;exoc-8 double mutant.
Exocyst complexes multiple functions in plant cells secretory pathways.
Pečenková et al., Praha, Czech Republic. In Curr Opin Plant Biol, 2013
The dramatic expansion of the EXO70 subunit gene family, of which individual members are likely responsible for exocyst complex targeting, implies that there are specialized functions of different exocysts with different EXO70s.
Arabidopsis exocyst subcomplex containing subunit EXO70B1 is involved in autophagy-related transport to the vacuole.
Zárský et al., Praha, Czech Republic. In Traffic, 2013
Here we report a role in autophagic membrane transport for EXO70B1--one of 23 paralogs of Arabidopsis EXO70 exocyst subunits.
Old AIMs of the exocyst: evidence for an ancestral association of exocyst subunits with autophagy-associated Atg8 proteins.
Zárský et al., Praha, Czech Republic. In Plant Signal Behav, 2013
Moreover, among the numerous EXO70 paralogs, the monocot-specific EXO70F clade appears to be exempt from the general AIM enrichment, suggesting a modification of the autophagy connection in a subset of exocyst variants.
The Arabidopsis exocyst subcomplex subunits involved in a golgi-independent transport into the vacuole possess consensus autophagy-associated atg8 interacting motifs.
Galili et al., In Plant Signal Behav, 2013
In the present addendum, by tooling a bioinformatics approach, we show that AtEXO70B1 as well as the additional 20 paralogs of Arabidopsis EXO70 exocyst subunits each possess one or more AIMs whose consensus sequence implies their high fidelity binding to Atg8.
EXO70A1-mediated vesicle trafficking is critical for tracheary element development in Arabidopsis.
Liu et al., Beijing, China. In Plant Cell, 2013
Genes encoding the EXO70 subunit are highly duplicated in plants.
ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.
Guo et al., Philadelphia, United States. In Dev Cell, 2012
Exocyst component Exo70 is a direct substrate of the extracellular signal-regulated kinases 1/2, their phosphorylation enhances the binding of Exo70 to other exocyst components and promotes the assembly of the exocyst complex.
An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization.
Ling et al., Rochester, United States. In Mol Biol Cell, 2012
PIPKIgamma and phosphatidyl inositol phosphate pools at nascent E-cadherin contacts cue Exo70 targeting and orient the tethering of exocyst-associated E-cadherin
Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans.
Jäntti et al., Helsinki, Finland. In Plos One, 2011
Here we characterize the mutant phenotypes for the exocyst complex genes exoc-7 (exo70) and exoc-8 (exo84) in Caenorhabditis elegans.
EXO70 protein influences dengue virus secretion.
Huang et al., Nanning, China. In Microbes Infect, 2011
This study identified that EXO70 protein, a member of the exocyst complex influenced DENV infection.
Expression and functional analyses of EXO70 genes in Arabidopsis implicate their roles in regulating cell type-specific exocytosis.
Liu et al., Beijing, China. In Plant Physiol, 2010
In contrast to a single gene in yeast and most animals, plants have greatly increased number of EXO70 genes in their genomes, with functions very much unknown.
Acute genetic perturbation of exocyst function in the rat calyx of Held impedes structural maturation, but spares synaptic transmission.
Kuner et al., Heidelberg, Germany. In Eur J Neurosci, 2010
In the rat calyx of Held, exocyst complex component 70 mediates the addition of membrane during postnatal presynaptic maturation.
The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis.
Brennwald et al., Chapel Hill, United States. In Mol Biol Cell, 2010
Data show that Exo70 has the biochemical properties expected of a direct effector for both Rho3 and Cdc42, and suggest that interaction with the Exo70 component of the exocyst is a key event in spatial regulation of exocytosis by Rho GTPases.
Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.
Cushman et al., Bethesda, United States. In J Biol Chem, 2009
fusion of GLUT4 vesicles is the rate-limiting step regulated by insulin downstream of Exo70-mediated tethering
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