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Even-skipped homeobox 2

This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Evx1, delta4, SP-D, ACID, TEL
Papers on EVX2
DNA methylation biomarkers for lung cancer.
Pfeifer et al., Duarte, United States. In Tumour Biol, 2012
Using sodium-bisulfite-based approaches, 12 CpG islands (associated with the BARHL2, EVX2, IRX2, MEIS1, MSX1, NR2E1, OC2, OSR1, OTX1, PAX6, TFAP2A, and ZNF577 genes) were confirmed to be methylated in 85% to 100% of the squamous cell carcinomas and 11 CpG islands (associated with the CHAD, DLX4, GRIK2, KCNG3, NR2E1, OSR1, OTX1, OTX2, PROX1, RUNX1, and VAX1 genes) were methylated in >80% of the adenocarcinomas.
2q31.1 microdeletion syndrome: redefining the associated clinical phenotype.
Debeer et al., Leuven, Belgium. In J Med Genet, 2011
Hemizygosity for HOXD13 and EVX2 genes was thought to cause the observed skeletal defects.
Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC).
Hou et al., Xi'an, China. In Bmc Cancer, 2010
Methylation of CALCA, CDH1, DAPK1, and EVX2 was more common in squamous cell carcinomas (SCC) compared to adenocarcinomas (ADC).
Mesomelic dysplasia Kantaputra type is associated with duplications of the HOXD locus on chromosome 2q.
Mundlos et al., Chiang Mai, Thailand. In Eur J Hum Genet, 2010
The more centromeric duplication encompasses the entire HOXD cluster, as well as the neighboring genes EVX2 and MTX2.
Evx2-Hoxd13 intergenic region restricts enhancer association to Hoxd13 promoter.
Kondo et al., Wako, Japan. In Plos One, 2006
Data show that the intergenic region between Evx2 and Hoxd13 behaves as a boundary element that functions differentially in space and time, specifically in the development of limbs, genital bud, and brain.
Cellular expression of eve1 suggests its requirement for the differentiation of the ameloblasts and for the initiation and morphogenesis of the first tooth in the zebrafish (Danio rerio).
Sire et al., Gif-sur-Yvette, France. In Dev Dyn, 2004
Although evx1 and evx2 were not reported to be expressed during mammalian tooth development, we present here evidence that eve1, the closest paralog of evx1 in the actinopterygian lineage, is expressed during pharyngeal tooth formation in the zebrafish, Danio rerio.
Comparison of even-skipped related gene expression pattern in vertebrates shows an association between expression domain loss and modification of selective constraints on sequences.
Laurenti et al., Paris, France. In Evol Dev, 2003
During subsequent evolution, two rounds of whole genome duplication followed by individual gene losses gave rise to three paralogs: evx1, evx2, and eve1.
A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly.
Scambler et al., London, United Kingdom. In Am J Hum Genet, 2002
117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly
Molecular cloning and analysis of a group of genes differentially expressed in cells which overexpress the Hoxa-1 homeobox gene.
Gudas et al., New York City, United States. In Exp Cell Res, 2000
Twenty-eight candidate genes were identified; these genes encode very diverse proteins, including signaling molecules such as BMP-4, the enzyme superoxide dismutase, the cell adhesion molecule cadherin-6, proteins involved in gene transcription such as HMG-1 and SAP18, homeodomain-containing proteins Gbx-2 and Evx-2, and cell cycle regulatory proteins such as the retinoblastoma binding protein-2.
Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1.
Rocchi et al., Roma, Italy. In Cytogenet Cell Genet, 1999
In this study we have used FISH to examine the relationship between a group of homeobox genes, namely DLX1/DLX2, EVX2 and four HOXD genes (10, 11, 12, 13), that map to region q31 on chromosome 2, and the FRA2G and FRA2H fragile sites located at 2q31 and 2q32.1 respectively.
Two cases with interstitial deletions of chromosome 2 and sex reversal in one.
Kingston et al., Manchester, United Kingdom. In Am J Med Genet, 1999
Microsatellite marker studies showed that both children had paternally derived deletions that included the HOXD gene cluster and the EVX2, DLX1, and DLX2 genes known to be important in limb development.
Expression of two even-skipped genes eve1 and evx2 during zebrafish fin morphogenesis and their regulation by retinoic acid.
Géraudie et al., Paris, France. In Int J Dev Biol, 1998
In the present work we have studied, by in situ hybridization, the expression and regulation of two vertebrate homologs eve1 and evx2 of the Drosophila pair-rule even-skipped gene family.
The exon-intron structure of human LHX1 gene.
Villa et al., Milano, Italy. In Biochem Biophys Res Commun, 1997
An intron at the same position also occurs in the Xlim 1 gene as well as in other homeobox genes, such as evx1 and evx2, suggesting that this intron insertion represents an ancestral event, from which homeobox genes of different families originated.
Function of the Evx-2 gene in the morphogenesis of vertebrate limbs.
Duboule et al., Genève, Switzerland. In Embo J, 1997
Evx-2, a gene related to the Drosophila even-skipped (eve) gene, is located close to Hoxd-13 and is expressed in limbs like the neighbouring Hoxd genes.
Zebrafish Hoxa and Evx-2 genes: cloning, developmental expression and implications for the functional evolution of posterior Hox genes.
Kondo et al., Genève, Switzerland. In Mech Dev, 1996
We have analysed the structural organization and expression of Abd-B related zebrafish HoxA cluster genes (Hoxa-9, Hoxa-10, Hoxa-11 and Hoxa-13) as well as of Evx-2, a gene closely linked to the HoxD complex.
Deletion of chromosome 2q24-q31 causes characteristic digital anomalies: case report and review.
Yang-Feng et al., Los Angeles, United States. In Am J Med Genet, 1995
HOXD13 and EVX2, located in the proximity of 2q31, were not deleted in our patient by Southern analysis.
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