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V-ets erythroblastosis virus E26 oncogene homolog 2

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: NET, CAN, V1a, HAD, ACID
Papers using Ets-2 antibodies
Factors influencing blood supply in wound granuloma quantitated by a new in vivo technique
Hodivala-Dilke Kairbaan M. et al., In Nature, 1988
... ETS2 overexpression in transgenic models and in Down ...
Papers on Ets-2
Seventeen-year trends in spring and autumn phenophases of Betula pubescens in a boreal environment.
Kubin et al., Oulu, Finland. In Int J Biometeorol, Jan 2016
The effective temperature sum at bud burst (ETS2) showed no trend in the southern and middle boreal zones, whereas ETS2 increased on average from 20-30 to 50 degree day units in the northern boreal zone, almost to the same level as in the other zones.
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas.
Fuchs et al., New York City, United States. In Elife, Dec 2015
Many of their genes, including Ets2 and Elk3, are themselves regulated by SCC-SC super-enhancers suggesting a cooperative feed-forward loop.
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.
Bekiranov et al., Charlottesville, United States. In Plos One, 2014
The transcriptional responses of ErbB pathway genes are associated with a number of transcription factors, including ETS2 and its associated cofactors that represent a convergent regulatory mechanism conferring synergistic drug susceptibility in the context of diverse mutational landscapes.
Seapolynol Extracted from Ecklonia cava Inhibits Adipocyte Differentiation in Vitro and Decreases Fat Accumulation in Vivo.
Lee et al., South Korea. In Molecules, 2014
This SN-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of SN on early adipogenic factors; SN downregulated the expression of Krueppel-like factor 4 (KLF4), KLF5, CCAAT-enhancer-binding protein β (C/EBPβ), C/EBPδ, and Protein C-ets-2 (ETS2), while KLF2, an anti-early adipogenic factor, was upregulated by SN.
Comparison of Gene Expression by Sheep and Human Blood Stimulated with the TLR4 Agonists Lipopolysaccharide and Monophosphoryl Lipid A.
Sherwood et al., Nashville, United States. In Plos One, 2014
Genes of major inflammatory mediators, such as IL-1, IL-6 and IL-8, TNF alpha, NF-kappaB, ETS2, PTGS2, PTX3, CXCL16, KYNU, and CLEC4E were similarly (>2-fold) upregulated by LPS and MPLA in both species.
Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.
Kaelin et al., Boston, United States. In Cancer Cell, 2014
We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor suppressor protein, which is an ubiquitin ligase component, leading to their destruction.
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.
Schwartz et al., Houston, United States. In Proc Natl Acad Sci U S A, 2012
Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.
The mutational landscape of lethal castration-resistant prostate cancer.
Tomlins et al., Ann Arbor, United States. In Nature, 2012
Similarly, we demonstrate that ETS2, which is deleted in approximately one-third of CRPCs (commonly through TMPRSS2:ERG fusions), is also deregulated through mutation.
Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells.
Roberts et al., Columbia, United States. In Mol Endocrinol, 2012
In embryonic stem cells [which express ETS2 (proto-oncogene c-ETS-2) but not CGA (alpha subunit chorionic gonadotropin)], ETS2 does not occupy binding site on CGA promoter but is found as soluble complex with POU5F1 (Oct3 transcription factor).
c-Jun and Ets2 proteins regulate expression of spleen tyrosine kinase in T cells.
Kyttaris et al., Boston, United States. In J Biol Chem, 2012
c-Jun in cooperation with Ets2 increases the expression of Syk and contributes to Syk-mediated heightened calcium responses in systemic lupus erythematosus T cells.
Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats.
Boheler et al., Baltimore, United States. In Aging Cell, 2012
conclude that variations in ETS2 abundance in hearts of adult rodents and the associated loss of cardiomyocytes contribute at least partially, to the longevity variability observed during normal aging of rats through activation of programmed necrosis
Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells.
Lin et al., Taipei, Taiwan. In Carcinogenesis, 2012
demonstrated that miR-196b was transcriptionally regulated by ETS2 and there was an inverse expression profile between miR-196b and ETS2 in clinical samples
Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320.
Ostrowski et al., Columbus, United States. In Nat Cell Biol, 2012
Downregulation of miR-320 and upregulation of one of its direct targets, ETS2 (v-ets erythroblastosis virus E26 oncogene homolog 2) are critical events in Pten-deleted stromal fibroblasts responsible for inducing this oncogenic secretome, which in turn promotes tumour angiogenesis and tumour-cell invasion.
Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.
Hodivala-Dilke et al., London, United Kingdom. In Nature, 2010
Recent work with the Ts65Dn model of DS, which has orthologues of about 50% of the genes on chromosome 21 (Hsa21), has indicated that three copies of the ETS2 (ref.
Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype.
Mrózek, Columbus, United States. In Semin Oncol, 2008
Several candidate genes have been identified as targets of genomic losses, for example, TP53, CTNNA1, NF1, ETV6, and TCF4, and amplifications, for example, ERG, ETS2, APP, ETS1, FLI1, MLL, DDX6, GAB2, MYC, TRIB1, and CDX2.
Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Ashworth et al., London, United Kingdom. In Cancer Cell, 2008
We demonstrate that CDK10 is an important determinant of resistance to endocrine therapies and show that CDK10 silencing increases ETS2-driven transcription of c-RAF, resulting in MAPK pathway activation and loss of tumor cell reliance upon estrogen signaling.
Transcription factors: molecular targets for prostate cancer intervention by phytochemicals.
Agarwal et al., Denver, United States. In Curr Cancer Drug Targets, 2007
This review focuses on the efficacy of various phytochemicals in targeting transcription factors such as AR, Sp1, STATs, E2F, Egr1, c-Myc, HIF-1 alpha, NF-kappaB, AP-1, ETS2, GLI and p53 in the context of prostate cancer intervention.
Mouse models of cognitive disorders in trisomy 21: a review.
Soumireu-Mourat et al., Marseille, France. In Behav Genet, 2006
Available mouse models carry extra fragments of MMU16 or of HSA21 that cover all of HSA21 (chimeric HSA21) or MMU16 (Ts16); some carry large parts of MMU16 (Ts65Dn, Ts1Cje, Ms1Cje), while others have reduced contiguous fragments covering the D21S17-ETS2 region or single transfected genes.
Oncogenes in chronic lymphocytic leukemia.
Gale et al., Los Angeles, United States. In Leuk Res, 1987
Exceptions include the bcl-1 oncogene in B-cell prolymphocytic leukemia, the tcl-1 oncogene in T-cell CLL, the Hu-ets-1 and Hu-ets-2 oncogenes in small cell lymphocytic lymphoma and c-myc in a Sezary cell leukemia cell/line.
Molecular evolution of ets genes from avians to mammals and their cytogenetic localization to regions involved in leukemia.
Ascione et al., Frederick, United States. In Gene Amplif Anal, 1985
The mammalian homolog of the 3' v-ets domain (ets-2) was similarly mapped to human chromosome 21, to mouse chromosome 16, and to feline chromosome C2.
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