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Ethanolamine kinase 2

ethanolamine kinase 2, ETNK2, Eki2, TUC-1
The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Renin, Tissue Plasminogen Activator, PAI-1, Angiotensin II, V1a
Papers on ethanolamine kinase 2
Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II α.
Kim et al., Seoul, South Korea. In Cancer Biol Ther, 2014
Interestingly, we found that the promoter-CpG islands of 5 previously identified radioresistance-related genes (TOPO2A, PLXDC2, ETNK2, GFI1, and IL12B) were significantly altered in the radioresistant laryngeal cancer cells.
Kinome siRNA screen identifies novel cell-type specific dengue host target genes.
Fink et al., South Korea. In Antiviral Res, 2014
While the expression of EIF2AK3, ETNK2 and SMAD7 was regulated in both cell lines after infection, most kinases were hepatocyte-specific.
Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
Williams et al., United States. In Plos One, 2010
Statistical modeling of pairwise interactions was done using two-way ANOVA between polymorphisms in the ETNK2, RENIN, ACE, PAI-1, t-PA, and AGT genes.
Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice.
Sinclair et al., Melbourne, Australia. In Endocrinology, 2008
No abnormalities were detected in the Eki2-deficient mice with regard to embryonic and adult testis morphology, differentiation, function, or fertility.
Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
Williams et al., Nashville, United States. In Hum Genet, 2008
In addition, a significant relationship was found between the PAI-1 4G/5G (rs1799768) polymorphism on PAI-1 levels in females, the TPA I/D (rs4646972) polymorphism on t-PA and PAI-1 in males, the renin (rs3730103) polymorphism on t-PA and PAI-1 in males, the ethanolamine kinase 2 (rs1917542) polymorphism on PAI-1 in males, and the renin (rs1464816) polymorphism on t-PA in females and on PAI-1 in males.
Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.
Smith et al., Dundee, United Kingdom. In Biochem J, 2008
brucei choline/ethanolamine kinase 2), on the other hand, was found to be able to phosphorylate both ethanolamine and choline, even though choline was the preferred substrate, with a K(m) 80 times lower than that of ethanolamine.
Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus.
Sigmund et al., Iowa City, United States. In Am J Physiol Renal Physiol, 2008
Phenotypically, these truncations cause a severe dysregulation of human renin expression, but remarkably, a preservation of the normal tissue-specific expression of the human ethanolamine kinase 2 (ETNK2) gene which lies immediately downstream of renin.
Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.
Jackowski et al., Memphis, United States. In J Biol Chem, 2006
In this work, the predicted Etnk2 cDNA was established as a soluble protein with ethanolamine-specific kinase activity that was most highly expressed in liver.
Eki2 is upregulated specifically in the testis during mouse sex determination.
Sinclair et al., Melbourne, Australia. In Gene Expr Patterns, 2004
Expression restricted to the Sertoli cells of the developing testis.
Differential proteome analysis of replicative senescence in rat embryo fibroblasts.
Jat et al., London, United Kingdom. In Mol Cell Proteomics, 2002
Changes in expression of TUC-1, -2, -4, and -4 beta, members of the TUC family critical for neuronal differentiation, were also identified.
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