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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Et-3 endothelin-3

ET-3, endothelin-3
Top mentioned proteins: endothelin-1, ETB, endothelin receptor, V1a, HAD
Papers on ET-3
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
Gulati, Downers Grove, United States. In Curr Neuropharmacol, Feb 2016
UNASSIGNED: The ET family consists of three isopeptides (ET-1, ET-2 and ET-3) that produce biological actions by acting on two types of receptors (ETA and ETB).
Epigenetic silencing of endothelin-3 in colorectal cancer.
Muc-Wierzgoń et al., Sosnowiec, Poland. In Int J Immunopathol Pharmacol, Jan 2016
ET-3 is a new candidate tumour suppressor gene, which is often downregulated or silenced in human cancer.The aim of the study was to examine DNA methylation of ET-3 genes in colorectal cancer (CRC) tissue samples in relation to the clinical stage (CS) of cancer.
Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells.
Krishnamoorthy et al., Fort Worth, United States. In Invest Ophthalmol Vis Sci, Oct 2015
METHODS: Primary RGCs isolated from rat pups were treated with 100 nM of ET-1, ET-2, or ET-3 for 24 hours.
The Na(x) Channel: What It Is and What It Does.
Hiyama et al., Okazaki, Japan. In Neuroscientist, Aug 2015
We recently demonstrated that the [Na(+)]o dependency of Na(x) in the subfornical organ was adjusted to the physiological range by endothelin-3.
Analysis of immunostaining and western blotting of endothelin 1 and its receptors in mitral stenosis.
Rodrigues et al., São Paulo, Brazil. In Rev Bras Cir Cardiovasc, Mar 2015
It is an autoimmune disease, which occurs in response to infection by streptococcus A. OBJECTIVE: The aim of this study was to evaluate the immunolabeling and protein expression for endothelin-1 and 3 (ET-1, ET-3) and its receptors (ETA, ETB) in rheumatic mitral valves.
Endothelin receptors and their antagonists.
Davenport et al., Cambridge, United Kingdom. In Semin Nephrol, Mar 2015
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform.
Sodium sensing in the brain.
Hiyama et al., Okazaki, Japan. In Pflugers Arch, Mar 2015
A local expression of endothelin-3 in the SFO modulates the [Na(+)] sensitivity for Nax activation, and thereby Nax is likely to be activated in the physiological [Na(+)] range.
Endothelin and the renal microcirculation.
Inscho et al., Birmingham, United States. In Semin Nephrol, Mar 2015
ET-1, ET-2, and ET-3 are the three distinct endothelin isoforms comprising the endothelin family.
Correlation between Saliva and Plasma Levels of Endothelin Isoforms ET-1, ET-2, and ET-3.
Vincent et al., Ottawa, Canada. In Int J Pept, 2014
Results revealed statistically significant positive correlations among all isoforms between saliva and plasma: big endothelin-1 (BET-1, 0.55 ± 0.27 versus 3.35 ± 1.28 pmol/mL; r = 0.38, p = 0.041), endothelin-1 (ET-1, 0.52 ± 0.21 versus 3.45 ± 1.28 pmol/mL; r = 0.53, p = 0.003), endothelin-2 (ET-2, 0.21 ± 0.07 versus 1.63 ± 0.66 pmol/mL; r = 0.51, p = 0.004), and endothelin-3 (ET-3, 0.39 ± 0.19 versus 2.32 ± 1.44 pmol/mL; r = 0.75, p < 0.001).
Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12.
Davenport et al., Cambridge, United Kingdom. In Br J Pharmacol, 2014
Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three structurally similar endogenous 21-amino acid peptides, ET-1, ET-2 and ET-3, that activate two GPCRs, ETA and ETB .
Endothelin-3 expression in the subfornical organ enhances the sensitivity of Na(x), the brain sodium-level sensor, to suppress salt intake.
Noda et al., Okazaki, Japan. In Cell Metab, 2013
Here, we found that the sensitivity of Na(x) channels to [Na(+)](o) is dose-dependently enhanced by endothelin-3 (ET-3).
Structure of the precursor of Xenopus laevis endothelin-3 and phylogenetic analysis.
Saida et al., Japan. In J Cardiovasc Pharmacol, 2004
This is the first report of the cDNA encoding the precursor protein of ET-3 in a non-mammalian species.
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
Davenport, Cambridge, United Kingdom. In Pharmacol Rev, 2002
In mammals, the endothelin (ET) family comprises three endogenous isoforms, ET-1, ET-2, and ET-3.
A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome).
Buys et al., Groningen, Netherlands. In Nat Genet, 1996
The mutation, Cys159Phe, in exon 3 in the ET-3 like domain of EDN3, presumably affects the proteolytic processing of the preproendothelin to the mature peptide EDN3.
Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome).
Lyonnet et al., Paris, France. In Nat Genet, 1996
Since mouse mutants for the EDNRB ligand, endothelin-3 (EDN3), displayed a similar phenotype, the EDN3 gene was regarded as an alternative candidate gene in WS-HSCR.
Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents.
Satake et al., Tokyo, Japan. In Nature, 1994
Endothelin-1, but not endothelin-3, inhibited the L-type calcium current by decreasing cyclic AMP accumulation and activated the muscarinic potassium current by stimulating a pertussis toxin-sensitive GTP-binding protein.
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