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Epithelial splicing regulatory protein 1

ESRP1, RBM35A, RNA-binding motif protein 35A
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009] (from NCBI)
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Top mentioned proteins: CD44, CAN, V1a, E-cadherin, FGFR2
Papers on ESRP1
Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer.
Ji et al., Beijing, China. In Gastric Cancer, Jan 2016
RESULTS: In the 129 patients, a copy number gain of three chromosome regions-namely, 8q22 (including ESRP1 and CCNE2), 8q24 (including MYC and TNFRSF11B), and 20q11-q13 (including SRC, MMP9, and CSE1L)-conferred poor survival for patients.
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Watanabe et al., Japan. In Oncotarget, Jan 2016
CRL and MDAMB453 cells were identified as PB-sensitive, while MDAMB231 cells were PB-resistant.RAB25 and ESRP1 were identified as key regulators of PB sensitivity, while ANKD1, ETS1, PTRF, IFI16 and KIAA1199 acted as PB resistance-related genes.
A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.
Stemmler et al., Freiburg, Germany. In Int J Cancer, Jan 2016
Remarkably, EMT-induced repression of ESRP1 controls alternative splicing of CD44, causing a shift in the expression from the variant CD44v to the standard CD44s isoform.
[The myeloid cell leukemia-1 mRNA splicing mediated by epithelial splicing regulatory protein 1 (ESRP1) in glioma U251 cell lines].
Zhang et al., Shanghai, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Nov 2015
To investigate the regulatory mechanism of myeloid cell leukemia-1 (MCL1) mRNA splicing mediated by epithelial splicing regulatory protein 1 (ESRP1) in glioma U251 cell lines.
SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.
Muñoz et al., Madrid, Spain. In Oncogene, Nov 2015
Moreover, SPRY2 represses LLGL2/HUGL2, PATJ1/INADL and ST14, main regulators of the polarized epithelial phenotype, and ESRP1, an epithelial-to-mesenchymal transition (EMT) inhibitor.
Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells.
Bühring et al., Tübingen, Germany. In Glycobiology, Aug 2015
Moreover, major epithelial cell-associated markers Claudin-7, E-cadherin, ESRP1 and GRHL2 were down-regulated in the SSEA-4(+) fraction of DU145 and HCT-116 cells.
HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial-mesenchymal transition.
Torrisi et al., Roma, Italy. In Int J Cancer, Aug 2015
Here, we report that, in cell models of transfected human keratinocytes as well as in cervical epithelial cells containing episomal HPV16, the down-regulation of FGFR2b induced by 16E5 is associated with the aberrant expression of the mesenchymal FGFR2c isoform as a consequence of splicing switch: in fact, quantitative RT-PCR analysis showed that this molecular event is transcriptionally regulated by the epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) and is able to produce effects synergistic with those caused by TGFβ treatment.
Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization.
Xing et al., Los Angeles, United States. In Mol Cancer Res, Feb 2015
These include splicing factors known to be differentially regulated in epithelial-mesenchymal transition (ESRP1, ESRP2, and RBFOX2), a cellular process critical for cancer metastasis, as well as novel findings (NOVA1 and MBNL3).
Brain metastasis is predetermined in early stages of cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome.
Hoon et al., Santa Monica, United States. In Pigment Cell Melanoma Res, 2015
ESRP1 and ESRP2 splicing factors correlate with CD44v6 expression in PRM, and ESRP1 knockdown significantly decreases CD44v6 expression.
Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas.
Ueland et al., Oslo, Norway. In Neuro Endocrinol Lett, 2014
We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response.
Confluence analysis of multiple omics on platinum resistance of ovarian cancer.
Ye, In Eur J Gynaecol Oncol, 2014
RESULTS: The author obtained 38 new SNPs after excluding 22 SNP from dbSNP database and 1000 Genomes Project and found ESRP1, LDHA, DDX5, and HEXA were associated with platinum resistance of ovarian cancer.
Epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) suppress cancer cell motility via different mechanisms.
Miyazawa et al., Tokyo, Japan. In J Biol Chem, 2014
ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 regulate alternative splicing events associated with epithelial phenotypes of cells, and both are down-regulated during the epithelial-mesenchymal transition.
Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition.
Heymach et al., Houston, United States. In Bmc Genomics, 2013
Genes related to the epithelial-to-mesenchymal transition, such as AXL, ESRP1, HoxB4, and SPINT1/2, were among the nearly 20% of the candidate genes that were differentially methylated between epithelial and mesenchymal cells.
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT).
Carstens et al., Philadelphia, United States. In Semin Cancer Biol, 2012
While long known splicing switches in FGFR2 and p120-catenin provided hints of a larger program of EMT-associated alternative splicing, the recent identification of the epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) began to reveal this genome-wide post-transcriptional network.
Gene expression profiling identifies ESRP1 as a potential regulator of epithelial mesenchymal transition in somatotroph adenomas from a large cohort of patients with acromegaly.
Bollerslev et al., Oslo, Norway. In J Clin Endocrinol Metab, 2012
ESRP1 could be a master regulator of the EMT process in pituitary adenomas causing acromegaly.
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.
Saitoh et al., Tokyo, Japan. In Oncogene, 2012
deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers
Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing.
Carstens et al., Philadelphia, United States. In Mol Cell Biol, 2012
functions of the ESRP1 in an epithelial posttranscriptional gene expression program.
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Nagano et al., Tokyo, Japan. In Nat Commun, 2011
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Gertler et al., Cambridge, United States. In Plos Genet, 2011
The functional significance of EMT-associated alternative splicing was tested by expression of the epithelial-specific splicing factor ESRP1
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.
Chinnaiyan et al., Ann Arbor, United States. In Nat Med, 2010
Here we used paired-end transcriptome sequencing to screen ETS rearrangement-negative prostate cancers for targetable gene fusions and identified the SLC45A3-BRAF (solute carrier family 45, member 3-v-raf murine sarcoma viral oncogene homolog B1) and ESRP1-RAF1 (epithelial splicing regulatory protein-1-v-raf-1 murine leukemia viral oncogene homolog-1) gene fusions.
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