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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Endothelial cell-specific molecule 1

ESM-1, Endocan, endothelial cell-specific molecule-1
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, vascular endothelial growth factor, AGE, POLYMERASE
Papers on ESM-1
Endothelial cell-specific molecule-1/endocan: Diagnostic and prognostic value in patients suffering from severe sepsis and septic shock.
Hoffmann et al., Mannheim, Germany. In J Crit Care, Feb 2016
PURPOSE: This study aims to assess the diagnostic and prognostic value of endocan in patients with severe sepsis or septic shock on a medical intensive care unit (ICU).
ANNALS EXPRESS: The Determination of Serum and Urinary Endocan Levels in Patients With Bladder Cancer.
Akcay et al., In Ann Clin Biochem, Feb 2016
BACKGROUND: Endocan (Endothelial cell-specific molecul-1, ESM-1) is a proteoglycan and plays an important role in angiogenesis and inflammation.
Human Endothelial Cell-Specific Molecule-1 (Endocan) and Coronary Artery Disease and Microvascular Angina.
Yeter et al., Ankara, Turkey. In Angiology, Feb 2016
UNASSIGNED: Endothelial cell-specific molecule-1 (endocan) is an immunoinflammatory marker linked to endothelial activation and dysfunction.
Relationship of Endothelial Cell-Specific Molecule 1 Level in Stress Hyperglycemia Patients With Acute ST-Segment Elevation Myocardial Infarction: A Pilot Study.
Fu et al., Xuzhou, China. In Angiology, Jan 2016
UNASSIGNED: Endothelial cell-specific molecule 1 ([ESM-1], endocan) is a new biomarker of endothelial dysfunction, which may be involved in the pathogenesis of atherosclerosis and stress hyperglycemia in patients with acute ST-segment elevation myocardial infarction (STEMI).
Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer.
Reyes et al., Cartagena, Colombia. In Int J Biol Markers, Jan 2016
Genes evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3.
Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas.
Wu et al., Wenzhou, China. In Endocrine, Jan 2016
Endocan, also called endothelial cell-specific molecule-1 (ESM1), has been described as a marker of neoangiogenesis.
Endocan and Soluble Triggering Receptor Expressed on Myeloid Cells-1 as Novel Markers for Neonatal Sepsis.
Kul et al., Ankara, Turkey. In Pediatr Neonatol, Dec 2015
Endocan is constitutively expressed by endothelial cells, and high levels of endocan may be of relevance for the promotion of systemic inflammation.
Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus.
Kucuk et al., Konya, Turkey. In Angiology, Dec 2015
Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothelial cells.
The Relationship Between Serum Endocan Levels With the Presence of Slow Coronary Flow: A Cross-Sectional Study.
Ulusoy et al., Ankara, Turkey. In Clin Appl Thromb Hemost, Dec 2015
BACKGROUND: The aim of this study was to investigate the relationship between endocan levels with the presence of slow coronary flow (SCF).
Endocan: A novel inflammatory indicator in cardiovascular disease?
Iyisoy et al., Ankara, Turkey. In Atherosclerosis, Nov 2015
Endocan (previously known as endothelial cell specific molecule-1, ESM-1), is a potential immunoinflammatory marker that may be linked to CVD.
Serum levels of endocan correlate with the presence and severity of pre-eclampsia.
Akcay et al., Ankara, Turkey. In Clin Exp Hypertens, Oct 2015
BACKGROUND: Endocan, a cysteine-rich dermatan sulfate proteoglycan expressed by endothelial cells, is seemed to be a new biomarker for endothelial dysfunction.
Endocan: a new molecule playing a role in the development of hypertension and chronic kidney disease?
Kanbay et al., Konya, Turkey. In J Clin Hypertens (greenwich), 2014
Recently, endocan-formerly known as endothelial cell-specific molecule 1 (ESM-1)--was found to be associated with entities such as cancer, hypertension, renal transplant rejection, and chronic renal failure.
Serum endocan levels in women with restless legs syndrome.
Kiskac et al., Turkey. In Neuropsychiatr Dis Treat, 2014
BACKGROUND: Endocan is a recently introduced marker of endothelial dysfunction.
Endocan: a novel circulating proteoglycan.
Shetty et al., Pondicherry, India. In Indian J Pharmacol, 2014
Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan.
ESM-1 regulates cell growth and metastatic process through activation of NF-κB in colorectal cancer.
Song et al., Taejŏn, South Korea. In Cell Signal, 2012
ESM-1 overexpression in HCT-116 cells enhanced cell proliferation through the Akt-dependent activation of NF-kappa-B pathway.
Expression and distribution of endocan in human tissues.
Wang et al., Hefei, China. In Biotech Histochem, 2012
endocan may act as a marker for angiogenesis or oncogenesis and could be regarded as a candidate gene for inflammatory tissue, neoplasia, tumor development and metastasis
Effects of peripheral blood stem cell apheresis on systemic cytokine levels in patients with multiple myeloma.
Bruserud et al., Bergen, Norway. In Cytotherapy, 2011
increased expression on microvascular endothelial cells following peripheral blood stem cell harvesting in patients with multiple myeloma
Serum levels of endothelium-derived endocan are increased in patients with untreated acute myeloid leukemia.
Bruserud et al., Bergen, Norway. In Hematology, 2011
Data suggest that serum endocan is a disease marker in AML.
ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma.
Song et al., Taejŏn, South Korea. In Amino Acids, 2011
Gene silencing of ESM-1 decreased cell survival, migration, an invasion in hepatocellular carcinoma.
Endocan or endothelial cell specific molecule-1 (ESM-1): a potential novel endothelial cell marker and a new target for cancer therapy.
Delehedde et al., Loos, France. In Biochim Biophys Acta, 2006
Endocan, previously called endothelial cell specific molecule-1, is a soluble proteoglycan of 50 kDa, constituted of a mature polypeptide of 165 amino acids and a single dermatan sulphate chain covalently linked to the serine residue at position 137.
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