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ERG2 Erg2p

ERG2, Erg2p, HERG2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ERG3, ACID, CAN, HAD, HERG
Papers on ERG2
HERG1A potassium channel is the predominant isoform in head and neck squamous cell carcinomas: evidence for regulation by epigenetic mechanisms.
García-Pedrero et al., Oviedo, Spain. In Sci Rep, Dec 2015
HERG2 and HERG3 were also detected.
ERG2 and ERG24 Are Required for Normal Vacuolar Physiology as Well as Candida albicans Pathogenicity in a Murine Model of Disseminated but Not Vaginal Candidiasis.
Palmer et al., Memphis, United States. In Eukaryot Cell, Oct 2015
It was found that overexpression of either the ERG2 or ERG24 gene, encoding C-8 sterol isomerase or C-14 sterol reductase, respectively, suppressed C. albicans sensitivity to the morpholines.
Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistance in vivo in Candida albicans orchestrated by multiple genetic alterations.
Arendrup et al., Copenhagen, Denmark. In J Antimicrob Chemother, Sep 2015
Additional genes were analysed by sequencing (including FKS1, ERG11, ERG2 and TAC1) and gene expression by quantitative PCR (CDR1, CDR2 and ERG11).
C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation.
Sanguinetti et al., Salt Lake City, United States. In Mol Pharmacol, Jul 2015
Compounds can activate human ether-à-go-go-related gene 1 (hERG1) channels by several different mechanisms, including a slowing of deactivation, an increase in single channel open probability, or a reduction in C-type inactivation.
MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma.
Liang et al., Shanghai, China. In Biochem Biophys Res Commun, Jun 2015
Furthermore, we demonstrated that ERG2 was an identical candidate target gene of MiR-224 in vitro.
[Effect of Huanglian Jiedu decoction in combination with fluconazole on ergosterol of fluconazole-resistant Candida albicans].
Wang et al., In Zhongguo Zhong Yao Za Zhi, Feb 2015
The expressions of ERG1, ERG2, ERG6, ERG7 and ERG11 were upregulated, and ACS1, ACS2, MET6 were downregulated when exposed to FLZ.
Genome-wide screening of Saccharomyces cerevisiae genes required to foster tolerance towards industrial wheat straw hydrolysates.
Domingues et al., Braga, Portugal. In J Ind Microbiol Biotechnol, 2014
Moreover, PRS3, VMA8, ERG2, RAV1 and RPB4 were confirmed as key genes on yeast tolerance and fermentation of industrial WSH.
Changes in the Sterol Composition of the Plasma Membrane Affect Membrane Potential, Salt Tolerance and the Activity of Multidrug Resistance Pumps in Saccharomyces cerevisiae.
Sychrová et al., Praha, Czech Republic. In Plos One, 2014
We investigated the impact of the deletions of genes from the final steps in the biosynthesis of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the Saccharomyces cerevisiae plasma membrane by a combination of biological tests and the diS-C3(3) fluorescence assay.
Heterologous expression of the Monilinia fructicola CYP51 (MfCYP51) gene in Pichia pastoris confirms the mode of action of the novel fungicide, SYP-Z048.
Liu et al., Fuzhou, China. In Front Microbiol, 2014
Previous studies have shown that EBIs target the proteins from a range of genes, including CYP51, ERG2 and/or ERG24, and ERG27, which are involved in the ergosterol biosynthesis pathway.
Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae.
Ching et al., Singapore, Singapore. In Microb Cell Fact, 2014
We found mRNA levels for ERG11, ERG2 and ERG3 expression were significantly lower in the engineered strain over the reference strain BY4742, indicating these genes are transcriptionally down-regulated when ergosterol is in excess.
Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes.
Svaren et al., Madison, United States. In J Neurochem, 2010
Erg2 was found to bind to promoters of several lipid biosynthesis genes during the formation of lipid-rich myelin.
No association between EGR gene family polymorphisms and schizophrenia in the Chinese population.
He et al., Shanghai, China. In Prog Neuropsychopharmacol Biol Psychiatry, 2010
The EGR2 may not play a major role in schizophrenia susceptibility in the Chinese Han population
Antineoplastic chemotherapy induced QTc prolongation.
Recondo et al., Buenos Aires, Argentina. In Curr Drug Saf, 2010
Among the newest compounds, symptomatic or asymptomatic QTc aberrations were reported with multitargeted tyrosine-kinase inhibitors, anti HERG2, anti-VEGF, vascular disruption agents and histone deacetylase inhibitors.
Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant.
Ushimaru et al., Shizuoka, Japan. In Fems Microbiol Lett, 2009
Here, it is shown that the deletion in ERG2, which encodes sterol C8-C7 isomerase (the next enzymatic step after Erg6), promotes the vacuolar degradation of Tat2.
[Regulation role of sterol C-24 methyltransferase and sterol C-8 isomerase in the ergosterol biosynthesis of Saccharomyces cerevisiae].
Zhang et al., Beijing, China. In Wei Sheng Wu Xue Bao, 2009
Overexpression of ERG6 and ERG2 led to an increased ergosterol level.
Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels.
Restano-Cassulini et al., Milano, Italy. In Toxicon, 2007
Three erg genes (erg1, erg2 and erg3) have been identified and characterized.
Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.
Espallergues et al., Paris, France. In Pharmacol Biochem Behav, 2006
Analysis of the sigma(1) protein sequence confirmed homologies with the ERG2/emopamil binding protein family but also with the steroidogenic enzymes isopentenyl diphosphate isomerase and 17beta-estradiol dehydrogenase.
Antifungal agents: mode of action in yeast cells.
Quindós et al., Barcelona, Spain. In Rev Esp Quimioter, 2006
The phenylmorpholines, of which amorolfine is the sole representative in human therapy, affect two targets in the ergosterol pathway: Erg24p (delta 14 reductase) and Erg2p (delta 8-delta 7 isomerase).
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
Milbrandt et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2005
One of the abnormally elevated genes in Egr2Lo/Lo Schwann cells, Sox2, encodes a transcription factor that is crucial for maintenance of neural stem cell pluripotency.
Genetic evaluation of inherited motor/sensory neuropathy.
Chance, Seattle, United States. In Suppl Clin Neurophysiol, 2003
Mutations in the SIMPLE gene cause CMT1C, and CMT1D is the result of mutations in the early response 2 (ERG2 or Krox-20) gene.
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