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Thyroid hormone receptor, alpha

erbA, c-erbA, TRalpha
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, TRbeta, CAN, HAD, V1a
Papers on erbA
Circadian rhythm of the Leydig cells endocrine function is attenuated during aging.
Kostic et al., Novi Sad, Serbia. In Exp Gerontol, Jan 2016
The majority of examined clock genes displayed circadian behavior in expression but only a few of them (Bmal1, Per1, Per2, Per3 and Rev-Erba) were reduced in 24-month-old group.
A mammalian circadian clock model incorporating daytime expression elements.
Ueda et al., Kōbe, Japan. In Biophys J, 2014
Our model reproduces predictions concerning the dual regulation of Cry1 by the D-box and Rev-ErbA/ROR response element (RRE) promoter elements and allows for ensemble-based predictions of phase response curves (PRCs).
Evaluation of plasma fibrinogen degradation products and total serum protein concentration in oral submucous fibrosis.
Prabhu et al., Gulbarga, India. In J Clin Diagn Res, 2014
Total Serum Protein (TSP) estimation was done by Biuret method using Liquixx Protein kit by Erba, Manheim.
V-erbA generates ribosomes devoid of RPL11 and regulates translational activity in avian erythroid progenitors.
Gonin-Giraud et al., Villeurbanne, France. In Oncogene, 2014
The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
Receptors of thyroid hormones.
Zambrano et al., Madrid, Spain. In Pediatr Endocrinol Rev, 2013
The important physiological actions of the thyroid hormones are mediated by binding to nuclear thyroid hormone receptors (TRs), encoded by two genes TRalpha and TRbeta.
Liver Function Profile Anomalies in HIV Seropositive Tuberculosis.
Dey et al., Calcutta, India. In J Clin Diagn Res, 2013
Some parameters of the serum Liver Function Test (LFT) were estimated biochemically by using an auto analyzer (ERBA XL600,Transasia).
Protein sequences involved in the mitochondrial import of the 3,5,3'-L-triiodothyronine receptor p43.
Cabello et al., Montpellier, France. In J Cell Physiol, 2012
The p43 sequences inducing its mitochondrial import, using in organello import experiments with wild-type or mutated proteins and validation in CV1 cells are characterized.
[Thyroid hormones and their precursors I. Biochemical properties].
Noszál et al., Budapest, Hungary. In Acta Pharm Hung, 2012
There are two major thyroid hormone receptor (TR) isoforms, alfa (TRalpha) and beta (TRbeta).
Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.
Seigneres et al., Beijing, China. In Curr Pharm Biotechnol, 2012
Here, like v-erbA, PML/RARa is a (strong) transcriptional repressor of the RA receptor (RAR) complex, and PML/RARa fusion receptor gene act as conditional oncogenic receptor (translocated chimeric retinoic acid a signaling) or oncogenic PML/RARa may participate in leukemogenesis of APL through blocking RA-mediated promyelocytic differentiation.
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.
Wondisford et al., São Paulo, Brazil. In Mol Endocrinol, 2012
the differential effects of thyroid hormone receptor isoforms on Tshb expression may be based on their differential DNA-binding affinity to the promoter.
Thyroid hormone receptor-α and vascular function.
Dillmann et al., Chicago, United States. In Am J Physiol Cell Physiol, 2012
found that TRalpha is the predominant TR in mouse coronary smooth muscle cells (SMCs). Coronary SMCs isolated from TRalpha knockout mice exhibited a significant decrease in K(+) channel activity
A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation.
Flamant et al., Lyon, France. In Mol Endocrinol, 2012
Mouse genetic indicates a cell-autonomous action of Thra in newborn mice oligodendrocyte differentiation and an indirect influence in cerebellar oligodendrocyte proliferation in adult.
Multi-level interactions between the nuclear receptor TRα1 and the WNT effectors β-catenin/Tcf4 in the intestinal epithelium.
Plateroti et al., Lyon, France. In Plos One, 2011
increased beta-catenin/Tcf4 levels i) correlated with reduced TRalpha1 transcriptional activity on its target genes and, ii) were likely responsible for the shift of TRalpha1 binding on WNT targets
Short-term effects of thyroid hormones during development: Focus on signal transduction.
Incerpi et al., Roma, Italy. In Steroids, 2010
However, also other thyroid hormone receptors can produce nongenomic effects, including the cytoplasmic TRalpha and TRbeta receptors and probably also a G protein-coupled membrane receptor, and increasing importance is now given to thyroid hormone metabolites like 3,5-diiodothyronine and reverse T(3) that can mimick some nongenomic effects of T(3) and T(4).
Nuclear receptor expression links the circadian clock to metabolism.
Evans et al., Los Angeles, United States. In Cell, 2006
While thyroid hormones are generally constant, we find that TRalpha and beta dramatically cycle, suggesting that fundamental concepts such as "basal metabolism" may require reexamination.
A transcription factor response element for gene expression during circadian night.
Hashimoto et al., Tsukuba, Japan. In Nature, 2002
Here we demonstrate the role of the Rev-ErbA/ROR response element in gene expression during circadian night, which is in phase with Bmal1 and in antiphase to Per2 oscillations.
A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation.
Karin et al., San Diego, United States. In Cell, 1994
Unlike classical HREs, this element, RSV-T3RE (found in Rous sarcoma virus-long terminal repeat), mediates strong activation by the c-ErbA alpha thyroid hormone (T3) receptor in the absence of T3, and addition of T3 reverses this response.
Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene.
Stehelin et al., In Science, 1984
Avian erythroblastosis virus (AEV) contains two distinct oncogenes, erbA and erbB .
A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas.
Toyoshima et al., In Cell, 1983
Using DNA probes specific for the LTR sequence of SR-RSV-A, and for the erbA gene and the erbB gene of the ES4 strain of AEV, we have shown that the genome of AEV-H is 35S in size and carries the erbB gene but not the erbA gene.
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