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Ets variant 1

ER81, ETV1
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: PEA3, ERM, CAN, TMPRSS2, FLI-1
Papers on ER81
Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
Janknecht et al., In J Clin Invest, Feb 2016
Moreover, combined overexpression of JMJD2A and the ETS transcription factor ETV1, a JMJD2A-binding protein, resulted in prostate carcinoma formation in mice haplodeficient for the phosphatase and tensin homolog (Pten) tumor-suppressor gene.
Novel genetic tools facilitate the study of cortical neuron migration.
Stottmann et al., Cincinnati, United States. In Mamm Genome, Jan 2016
To address both of these unresolved issues, we report here the creation of a novel conditional allele of the Reelin gene and showcase the use of an Etv1-GFP transgenic line highlighting a subpopulation of the cortex: layer V pyramidal neurons.
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
Dixit et al., San Francisco, United States. In Cell, Jan 2016
Here, we show that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in β cells is critical for insulin secretion.
Molecularly Defined Circuitry Reveals Input-Output Segregation in Deep Layers of the Medial Entorhinal Cortex.
Nolan et al., Edinburgh, United Kingdom. In Neuron, Jan 2016
We find that neurons in layers 5a and 5b have distinct molecular identities, defined by the transcription factors Etv1 and Ctip2, and divergent targets, with extensive intratelencephalic projections originating in layer 5a, but not 5b.
Development of Castration Resistant Prostate Cancer Can Be Predicted by a DNA Hypermethylation Profile.
Ropero et al., Getafe, Spain. In J Urol, Dec 2015
Hypermethylation of ETV1 (HR 3.75) and ZNF215 (HR 2.89) predicted disease progression despite androgen deprivation.
The Molecular Taxonomy of Primary Prostate Cancer.
Cancer Genome Atlas Research Network et al., In Cell, Dec 2015
Our results revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma.
Imyanitov et al., Saint Petersburg, Russia. In Gastrointest Tumors, Sep 2015
However, polymerase chain reaction testing for ES-specific rearrangements (EWSR1/FLI1, EWSR1/ERG, EWSR1/ETV1, EWSR1/ETV4, EWS/FEV) failed to confirm the ES origin of the neoplastic tissue.
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Chinnaiyan et al., Ann Arbor, United States. In Genome Med, 2014
Tumor-specific gene fusions can serve as diagnostic biomarkers or help define molecular subtypes of tumors; for example, gene fusions involving oncogenes such as ERG, ETV1, TFE3, NUT, POU5F1, NFIB, PLAG1, and PAX8 are diagnostically useful.
ETS fusion genes in prostate cancer.
Trapman et al., Rotterdam, Netherlands. In Endocr Relat Cancer, 2014
During the last few years, novel concepts of the process of gene fusion have emerged, and initial experimental results explaining the function of the ETS genes ERG and ETV1 in prostate cancer have been published.
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.
Sawyers et al., New York City, United States. In Nat Med, 2013
Similarly, ETS variant 1 (ETV1) positively regulated the AR cistrome and transcriptional output in ETV1-translocated, PTEN-deficient human prostate cancer cells.
Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation.
Gribben et al., London, United Kingdom. In J Clin Oncol, 2013
RESULTS: The most upregulated genes in both CD4 and CD8 TILs were PMCH, ETV1, and TNFRSF9.
ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors.
Janknecht et al., Oklahoma City, United States. In Biochim Biophys Acta, 2012
The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS transcription factors.
Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
Nakanishi et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2012
Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1.
MAPKAP kinase 2 overexpression influences prognosis in gastrointestinal stromal tumors and associates with copy number variations on chromosome 1 and expression of p38 MAP kinase and ETV1.
Schoppmann et al., Vienna, Austria. In Clin Cancer Res, 2012
Data show that MAPKAP kinase 2 overexpression is associated with expression of p38 MAP kinase and ETV1 in gastrointestinal stromal tumors (GIST).
The role of Pea3 group transcription factors in esophageal squamous cell carcinoma.
El-Tanani et al., Belfast, United Kingdom. In Am J Pathol, 2011
Pea3 and Erm, but not Er81, play an important role in the progression of esophageal squamous cell carcinoma
The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Nakanishi et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2011
Etv1 orchestrates the activity-dependent gene regulation in the terminal maturation program and specifies the identity of cerebellar granule cells.
PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma.
Sharrocks et al., Manchester, United Kingdom. In Br J Cancer, 2011
High ER81 expression is associated with gastric adenocarcinoma.
COP1 is a tumour suppressor that causes degradation of ETS transcription factors.
Dixit et al., San Francisco, United States. In Nature, 2011
The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26 transformation-specific (ETS) family, which includes the most frequently rearranged and overexpressed genes in prostate cancer.
ETS gene fusions in prostate cancer.
Cooper et al., Male, Maldives. In Nat Rev Urol, 2009
Fusions involving ETV1, ETV4 and ETV5 occur less frequently but exhibit greater variability in fusion structure with 12 unique 5' fusion partners identified so far.
Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family.
Liu et al., Melbourne, Australia. In Ann N Y Acad Sci, 2007
ER81 may mediate telomerase activation in telomerase-negative fibroblasts stimulated by oncogenes Her2/Neu, Ras, and Raf.
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