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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ES cell expressed Ras

ER as
Top mentioned proteins: CAN, endothelin-1, HAD, ACID, V1a
Papers on ER as
Kinetic Mechanism of Formation of Hyperactive Embryonic Ras in Cells.
Heo et al., Arlington, United States. In Biochemistry, Feb 2016
UNASSIGNED: Embryonic Ras (ERas)-a new subset of Ras proteins-are characterized by a unique p-loop residue, unique Switch II residues, and an unusual extended N-terminus.
The PR status of the originating cell of ER/PR-negative mouse mammary tumors.
Li et al., Houston, United States. In Oncogene, Jan 2016
In conclusion, our data demonstrate that ErbB2-initiated ER/PR-negative mammary tumors primarily originate from the subset of the mammary epithelium that is negative for PR and probably ER as well.
Memantine ER/Donepezil: A Review in Alzheimer's Disease.
Greig, Auckland, New Zealand. In Cns Drugs, Nov 2015
Memantine ER plus ChEI combination therapy was generally well tolerated in the phase III trial, with diarrhoea, dizziness and influenza occurring at least twice as often with add-on memantine ER as add-on placebo in donepezil-treated patients.
Pathways and Drugs in Pulmonary Arterial Hypertension - Focus on the Role of Endothelin Receptor Antagonists.
De Caterina et al., Chieti, Italy. In Cardiovasc Drugs Ther, Oct 2015
In patients who are acute-vasoreactive, classical treatments for PAH are calcium channels blockers (CCBs), while drugs targeting the prostacyclin, nitric oxide and endothelin pathways, i.e., prostanoids, phosphodiesterase (PDE)-5 inhibitors and endothelin receptor antagonists (ERAs), respectively, are indicated in non-vasoreactive patients or in vasoreactive patients not responding to initial CCB therapy.
[Efficacy of inhaled iloprost on top of other targeted therapies for patients with pulmonary hypertension and severe right heart failure].
Jing et al., Shanghai, China. In Zhonghua Xin Xue Guan Bing Za Zhi, Sep 2015
Inhaled iloprost was administrated to all enrolled patients, oral endothelin antagonist receptors (ERAs) and/or type 5 phosphodiasterase inhibitors (PDE5-I) were also used as basis therapies.
Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane.
Kutay et al., Zürich, Switzerland. In Curr Opin Cell Biol, Jun 2015
These studies reveal that nuclear retention, diffusional mobility in the ER as well as the number and architecture of NPCs are major determinants of INM targeting, collectively lending support to a diffusion-retention-based mechanism.
The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge.
Pawliczak et al., Łódź, Poland. In Respir Res, 2014
While mRNA expression of ERAS in PBMCs was increased (1.15 ± 0.23) in AIA in comparison to HV (-1.32 ± 0.41), (p = 0.03).
Dysfunction of Endoplasmic Reticulum (ER) and Mitochondria (MT) in Alzheimer's Disease: The Role of the ER-MT Cross-Talk.
Penke et al., Szombathely, Hungary. In Curr Alzheimer Res, 2014
The formation of misfolded proteins and toxic aggregates point to a common pathway of these disorders: failure in normal protein folding in the ER as a consequence of ER-stress and mitochondrial energy production.
The limits of oral therapy in pulmonary arterial hypertension management.
Jing et al., Shanghai, China. In Ther Clin Risk Manag, 2014
Over the past decade, new treatments for PAH, such as the use of ERAs, PDE-5 inhibitors and prostacyclin analogs, have brought about dramatic improvements in clinical outcomes.
Photoinitiator-Initiated Estrogenic Activity in Human Breast Cancer Cell Line MCF-7.
Sendo et al., Okayama, Japan. In J Toxicol Environ Health A, 2014
Data demonstrated that the six photoinitiators produced endocrine-disrupting effects and that these photoinitiators interacted with ER as agonists.
Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons.
Hammer et al., Bethesda, United States. In Nat Cell Biol, 2011
We show here that myosin-Va acts as a point-to-point organelle transporter to pull ER as cargo into Purkinje neuron spines.
Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells.
Asai et al., Nagoya, Japan. In Int J Oncol, 2010
ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma.
Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer.
Joh et al., Nagoya, Japan. In Am J Pathol, 2010
These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin.
Detection of β-catenin, gastrokine-2 and embryonic stem cell expressed ras in gastric cancers.
Yan et al., Shanghai, China. In Int J Clin Exp Pathol, 2009
ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted.
Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells.
Hirakawa et al., Ōsaka, Japan. In Int J Oncol, 2009
Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer.
Expression of ERas oncogene in gastric carcinoma.
Hirakawa et al., Ōsaka, Japan. In Anticancer Res, 2009
High ERas is associated with the tumorigenic process of gastric carcinomas.
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
Soengas et al., Ann Arbor, United States. In Nat Cell Biol, 2006
These results argue against premature senescence as a converging mechanism of response to activating oncogenes and support a direct role of the ER as a gatekeeper of tumour control.
Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.
Levin et al., Baltimore, United States. In Cell, 2004
We also show that GTP bound Ras2 associates with the GPI-GnT complex in vivo and inhibits its activity, indicating that yeast Ras uses the ER as a signaling platform from which to negatively regulate the GPI-GnT.
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.
Yamanaka et al., Ikoma, Japan. In Nature, 2003
transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells
Golgi membranes are absorbed into and reemerge from the ER during mitosis.
Lippincott-Schwartz et al., Bethesda, United States. In Cell, 2000
In mitosis, when ER export stops, Golgi proteins redistributed into the ER as shown by quantitative imaging in vivo and immuno-EM.
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