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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Transmembrane channel-like 6

Epidermodysplasia Verruciformis, EVI
Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Warts, CAN, POLYMERASE, AML1
Papers on Epidermodysplasia Verruciformis
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.
Augustin et al., Heidelberg, Germany. In Dev Cell, Feb 2016
Rspo3-iECKO mice strikingly phenocopied the non-canonical WNT signaling-induced vascular defects of mice deleted for the WNT secretion factor Evi/Wls.
Acquired Epidermodysplasia Verruciformis Associated with Human Papilloma Virus Type 14 in a Small Bowel Transplanted Child-A Case Report.
Honda et al., Cleveland, United States. In Pediatr Dermatol, Jan 2016
A biopsy diagnosed epidermodysplasia verruciformis (EV) that was found to be associated with human papillomavirus (HPV) type 14 according to polymerase chain reaction analysis.
The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review).
Jiang et al., Jinan, China. In Int J Oncol, Dec 2015
Ecotropic virus integration site-1 (EVI-1) gene, locus on chromosome 3 (3q26.2) in the human genome, was first found in the AKXD strain of mice, in a model of retrovirus-induced acute myeloid leukemia (AML) established twenty years ago.
Adult T-cell Lymphoma Complicated with Epidermodysplasia Verruciformis-like Eruptions.
Katoh et al., Kyoto, Japan. In Acta Dermatovenerol Croat, Dec 2015
Patients with epidermodysplasia verruciformis (EV) present in childhood with numerous thin, pink, flat papules and plaques that resemble verruca plana (3).
Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report.
Zhao et al., Tianjin, China. In Oncol Lett, Sep 2015
Thus far, ~150 cases of CNL have been described in the literature; however, none have demonstrated overexpression of the ecotropic viral integration site-1 (EVI-1, also known as MECOM) gene.
RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study.
Zhong et al., Shanghai, China. In Bmc Cancer, 2014
BACKGROUND: Acute myeloid leukemia (AML) 1-Evi-1 is a chimeric gene generated by the t (3; 21) (q26; q22) translocation, which leads into malignant transformation of hematopoietic stem cells by unclear mechanisms.
Acute myeloid leukemia presenting with panhypopituitarism or diabetes insipidus: a case series with molecular genetic analysis and review of the literature.
Altman et al., Chicago, United States. In Leuk Lymphoma, 2014
Four of five patients had monosomy 7. Three patients had chromosome 3q21q26/EVI-1 gene rearrangements.
Epidermodysplasia verruciformis.
Itin et al., Basel, Switzerland. In Curr Probl Dermatol, 2013
Epidermodysplasia verruciformis (EV) is a rare genodermatosis that predisposes certain individuals to developing cutaneous malignancies caused by infectious agents.
Acquired epidermodysplasia verruciformis: a comprehensive review and a proposal for treatment.
Feliciani et al., Roma, Italy. In Dermatol Surg, 2013
BACKGROUND: Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by immunologic abnormalities, disseminated human papilloma virus infection, and early development of skin cancers.
Epidermodysplasia verruciformis associated with HPV 10.
Ehrlich et al., Washington, D.C., United States. In Dermatol Online J, 2012
Epidermodysplasia verruciformis (EV) is a rare, inherited dermatologic condition demonstrating an increased susceptibility to specific HPV genotypes, resulting in both benign and malignant skin lesions.
Active Wnt proteins are secreted on exosomes.
Boutros et al., Heidelberg, Germany. In Nat Cell Biol, 2012
Together with the cargo receptor Evi/WIs, Wnts are transported through endosomal compartments onto exosomes, a process that requires the R-SNARE Ykt6.
Wntless functions in mature osteoblasts to regulate bone mass.
Williams et al., Grand Rapids, United States. In Proc Natl Acad Sci U S A, 2012
Wls-deficient osteoblasts had a defect in differentiation and mineralization, with significant reductions in the expression of key osteoblast differentiation regulators.
Evi5 promotes collective cell migration through its Rab-GAP activity.
Emery et al., Montréal, Canada. In J Cell Biol, 2012
The uncharacterized Drosophila protein Evi5 was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 regulates BC migration was described.
Functional characterization of mammalian Wntless homolog in mammalian system.
Hsu et al., Kao-hsiung, Taiwan. In Kaohsiung J Med Sci, 2012
Wntless plays a role in signaling regulation during the formation of cancer in addition to its role as a retromer protein in mammalian systems.
Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis.
Guo et al., Shanghai, China. In Dev Biol, 2012
These findings provide a comprehensive view of the Wls-mediated role of Wnts in limb patterning and tissue morphogenesis.
Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons.
Budnik et al., Worcester, United States. In J Biol Chem, 2012
Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.
Ferrying wingless across the synaptic cleft.
Zinsmaier et al., Tucson, United States. In Cell, 2009
Korkut et al. (2009) report that the transmembrane protein Evi is a versatile carrier that guides Wingless to presynaptic terminals of motor neurons and then escorts it across the synaptic cleft.
Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless.
Budnik et al., Worcester, United States. In Cell, 2009
These findings uncover a previously unknown cellular mechanism by which a secreted Wnt is transported across synapses by Evi-containing vesicles and reveal trafficking functions of Evi in both the Wnt-producing and the Wnt-receiving cells.
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Kurokawa et al., Tokyo, Japan. In Cell Stem Cell, 2008
Evi-1 has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia.
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.
Vincent et al., London, United Kingdom. In Nat Cell Biol, 2008
Overexpression of Wntless, a transmembrane protein known to be specifically required for Wingless secretion overcomes the secretion block of Vps35-mutant cells.
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