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EPH receptor A8

EphA8, Eek
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eph, SEK, EphA7, EphA2, HAD
Papers using EphA8 antibodies
The New S Language: A Programming Environment for Data Analysis and Graphics;
Zhang Lin, In PLoS ONE, 1997
... rabbit anti-EphA7 (Abgent, San Diego, CA; clone RB1641/RB1642) and synthetic blocking peptide (Abgent; BP7612b); rabbit EphA8 (Abnova, PAB3015); rabbit anti-ephrin-A1 (Amgen/Immunex, ...
Papers on EphA8
Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation.
Cornelison et al., Montréal, Canada. In J Cell Biol, Jan 2016
The repulsive guidance ligand ephrin-A3 is expressed only on slow myofibers, whereas its candidate receptor, EphA8, localizes exclusively to fast motor endplates.
EphA receptors form a complex with caspase-8 to induce apoptotic cell death.
Park et al., Seoul, South Korea. In Mol Cells, Apr 2015
EphA4 also had a causative role in inducing apoptotic cell death with caspase-8, whereas EphA8 did not.
miR-10a controls glioma migration and invasion through regulating epithelial-mesenchymal transition via EphA8.
Yang et al., Tianjin, China. In Febs Lett, Apr 2015
In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 (EphA8).
EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma.
MacDonald et al., Atlanta, United States. In J Neurooncol, 2015
We found EPHB4 and EFNA4 almost exclusively expressed by SHH MB, whereas EPHA2, EPHA8, EFNA1 and EFNA3 are predominantly expressed by non-SHH MB.
Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data.
Gao et al., Beijing, China. In Exp Mol Pathol, 2014
By integrating DNA methylation and mRNA expression data, we identified 3 hypermethylated genes showing concurrent down-regulation (PRKG1, PARD3, EPHA8) and 2 hypomethylated genes showing increased expression (STAT3, IFNGR1).
Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development.
Park et al., Seoul, South Korea. In Dev Neurobiol, 2013
Ectopic expression of EphA8-Fc in transgenic embryos induced apoptosis of neural epithelial cells, which was accompanied by a dramatic decrease in brain size.
RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.
Katada et al., Tokyo, Japan. In Plos One, 2011
RINL, as a GEF for Rab5 subfamily, is implicated in the EphA8-degradation pathway via its interaction with odin.
Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map.
Park et al., Seoul, South Korea. In Embo J, 2011
Here, we show that an endocytosis-defective EphA8 mutant forms a complex with EphAs and blocks their endocytosis in cultured cells.
Region-specific gene expression in early postnatal mouse thalamus.
Shimogori et al., Saitama, Japan. In J Comp Neurol, 2011
We also identified genes that are selectively expressed in multiple different nuclei (Foxp2, Chst2, and EphA8).
Expression profiling of the ephrin (EFN) and Eph receptor (EPH) family of genes in atherosclerosis-related human cells.
Yamagishi et al., Suita, Japan. In J Int Med Res, 2010
The following 17 members were detected in adult human peripheral blood monocytes: EFNA1 and EFNA3 - EFNA5 (coding for ephrins A1 and A3 - A5); EPHA1, EPHA2, EPHA4 - EPHA6 and EPHA8 (coding for Eph receptors A1, A2, A4 - A6 and A8); EFNB1 and EFNB2 (coding for ephrins B1 and B2); and EPHB1 - EPHB4 and EPHB6 (coding for Eph receptors B1 - B4 and B6).
Developmental expression of Eph and ephrin family genes in mammalian small intestine.
Montgomery et al., Boston, United States. In Dig Dis Sci, 2010
In contrast, levels of EphA4, EphA8, EphB4, and ephrin-B2 messenger RNA (mRNA) were highest during early fetal development and declined with age.
Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.
Lemmon et al., Miami, United States. In Mol Syst Biol, 2010
Proteins previously implicated in neurite growth, such as ERK1, GSK3, EphA8, FGFR, PI3K, PKC, p38, and PP1a, were confirmed to have effects in our functional assays.
Ectopic Expression of Ephrin-A5 Under the EphA8 Promoter at the Anterior Region of the Superior Colliculus.
Park et al., Seoul, South Korea. In Exp Neurobiol, 2010
In this study, EphA8 bacterial artificial chromosome (BAC) was manipulated to contain a floxed eGFP and human ephrin-A5 expression cassette using homologous recombination method.
EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.
Park et al., Seoul, South Korea. In Mol Cells, 2010
In this study, we show that EphA8 undergoes clathrin-mediated endocytosis upon treatment with ephrin-A5, and that EphA8 is associated tightly with Tiam-1, a Rac-specific guanine nucleotide exchange factor.
The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
Park et al., Seoul, South Korea. In Mol Cell Biol, 2010
Data suggest that Odin levels play a critical role in regulating the stability of EphA2 and A8 in response to ligand stimulation and by modulating the ubiquitination process.
Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.
Park et al., Seoul, South Korea. In Mol Cell Biol, 2007
These findings support a possible function for Anks family proteins as scaffolding proteins of the EphA8 signaling pathway.
Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.
Park et al., Seoul, South Korea. In Mol Cell Biol, 2007
Regulation of EphA8 gene expression is accomplished by TALE homeobox transcription factors during development of the mesencephalon.
The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells.
Park et al., Seoul, South Korea. In Oncogene, 2005
EphA8 receptor is capable of inducing a sustained increase in MAPK activity, thereby promoting neurite outgrowth in neuronal cells
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