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EPH receptor A1

Eph, EphA1
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, EphA2, Ephrin-B1, SEK, Ephrin-B2
Papers on Eph
Coulthard et al., South Brisbane, Australia. In Shock, Feb 2016
The Eph/ephrin receptor ligand system plays a role in inflammation through a signaling cascade, which modifies Rho-GTPase activity.
Bradykinin receptors and EphB2/EphrinB2 pathway in response to high glucose-induced osteoblast dysfunction and hyperglycemia-induced bone deterioration in mice.
Liu et al., Xi'an, China. In Int J Mol Med, Feb 2016
UNASSIGNED: This study was carried out in order to investigate bone dysfunction and the involvement of bradykinin receptors and the Eph/Ephrin signaling pathway in osteoblasts and in mice with diabetes-related osteoporosis in response to exposure to high glucose.
Interaction of Quercetin of Onion with Axon Guidance Protein Receptor, NRP-1 Plays Important Role in Cancer Treatment: An In Silico Approach.
Hossain et al., Dhaka, Bangladesh. In Interdiscip Sci, Jan 2016
Similarly, Eph receptors and ephrin ligands play critical roles in various biological functions, and deregulated activation of Eph/ephrin signaling in humans is thought to lead to tumorigenesis.
Over-Expression of Ephrin-A5 in Mice Results in Decreasing the Size of Progenitor Pool through Inducing Apoptosis.
Park et al., Seoul, South Korea. In Mol Cells, Jan 2016
UNASSIGNED: Eph receptors and their ligands, ephrins, mediate cell-to-cell contacts in a specific brain region and their bidirectional signaling is implicated in the regulation of apoptosis during early brain development.
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Pocock et al., London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 and SORL1) [2-8], and many encode proteins which are highly expressed in microglia [1].
The role of Eph/ephrin molecules in stromal-hematopoietic interactions.
Gronthos et al., Adelaide, Australia. In Int J Hematol, Nov 2015
Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands.
The Role of Ephs and Ephrins in Memory Formation.
Lamprecht et al., Haifa, Israel. In Int J Neuropsychopharmacol, Oct 2015
The Eph receptors and their cognate ephrin ligands have been shown to be involved in these key neuronal processes by regulating events such as presynaptic transmitter release, postsynaptic glutamate receptor conductance and trafficking, synaptic glutamate reuptake, and dendritic spine morphogenesis.
Eph receptors and ephrins: therapeutic opportunities.
Pasquale et al., Los Angeles, United States. In Annu Rev Pharmacol Toxicol, 2014
The erythropoietin-producing hepatocellular carcinoma (Eph) receptor tyrosine kinase family plays important roles in developmental processes, adult tissue homeostasis, and various diseases.
Targeting the Eph System with Peptides and Peptide Conjugates.
Pasquale et al., Los Angeles, United States. In Curr Drug Targets, 2014
Eph receptor tyrosine kinases and ephrin ligands constitute an important cell communication system that controls development, tissue homeostasis and many pathological processes.
Eph/Ephrins-Mediated Thymocyte-Thymic Epithelial Cell Interactions Control Numerous Processes of Thymus Biology.
Zapata et al., Madrid, Spain. In Front Immunol, 2014
The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant.
Therapeutic targeting of EPH receptors and their ligands.
Lackmann et al., Brisbane, Australia. In Nat Rev Drug Discov, 2014
Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized.
Antioxidant Effect and Functional Properties of Hydrolysates Derived from Egg-White Protein.
Oh et al., Seoul, South Korea. In Korean J Food Sci Anim Resour, 2013
The emulsifying activity index (EAI) of EPH treated with Neutrase decreased, as the pH decreased.
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans.
Alzheimer Disease Genetics Consortium et al., New York City, United States. In Jama, 2013
Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001).
Growth factor receptors define cancer hierarchies.
Rich et al., Cleveland, United States. In Cancer Cell, 2013
Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells.
EphrinA1 is released in three forms from cancer cells by matrix metalloproteases.
Debinski et al., Winston-Salem, United States. In Mol Cell Biol, 2012
EphrinA1 is released in three forms from cancer cells by matrix metalloproteases
Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor.
Debinski et al., Winston-Salem, United States. In J Biol Chem, 2012
analysis of structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor
EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes.
Groves et al., Berkeley, United States. In Biophys J, 2012
Ephrin-A1 activates EphA2 on the surface of MDA-MB-231 human breast cancer cells.
The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.
Wendel et al., New York City, United States. In Cell, 2011
In analogy to its physiological function in brain development, a soluble splice variant of EPHA7 (EPHA7(TR)) interferes with another Eph-receptor and blocks oncogenic signals in lymphoma cells.
Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
Watanabe et al., Sapporo, Japan. In Int J Oncol, 2011
The present study reveals a novel function for EphA1 and EphB2 in the induction of autophagy, suggesting a tumor suppressor role for these proteins in colorectal cancer.
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Schellenberg et al., Miami, United States. In Nat Genet, 2011
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
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