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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Prostaglandin E receptor 4

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EP2, V1a, cyclooxygenase, EP1, EP3
Papers using EP4 antibodies
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.
Qin Gangjian, In PLoS ONE, 1996
... peptides for EP1, EP2, EP3, EP4; and the agonists for EP2 (Butaprost), EP3 (Sulprostone), and EP4 (PGE1 Alcohol) were from Cayman Chemical (Ann Arbor, MI) ...
Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration
Heinemann Akos et al., In Cellular and Molecular Life Sciences, 1991
... Polyclonal rabbit anti-human EP4 receptor antibodies directed against the C terminus of the receptor were provided by Sigma and Cayman.
Papers on EP4
Limitations of Ber-EP4 for differentiation of Bowen disease from basal cell carcinoma.
Hassel et al., Heidelberg, Germany. In J Cutan Pathol, Feb 2016
Ber-EP4 staining is diagnostically reliable for differentiation between BCC and cutaneous squamous cell carcinoma [1, 2].
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
Picado et al., Barcelona, Spain. In Rhinology, Feb 2016
RESULTS: NM-C and NP-AERD samples and fibroblasts expressed EP2, EP3 and EP4 at baseline.
Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2.
Wang et al., Xiamen, China. In Oncotarget, Feb 2016
After treating cells with a COX-2 inhibitor or an EP4 antagonist, we established that HSC-induced MDSC accumulation was mediated by the COX2-PGE2-EP4 signaling.
Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke.
Wang et al., Guangzhou, China. In Prostaglandins Other Lipid Mediat, Jan 2016
There is clear evidence that activation of EP2 and EP4 receptors exerts cerebroprotection against ischemic stroke.
Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile.
Warshawsky et al., Indianapolis, United States. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: Two new series of EP4 antagonists containing a 3-methylaryl-2-carbonyl core have been identified.
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Houston et al., Cork, Ireland. In Br J Pharmacol, Nov 2015
The biological effects of PGE2 are mediated by signalling through four distinct E-type prostanoid (EP) receptors - EP1 , EP2 , EP3 and EP4 .
Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System.
Yamamoto et al., Himeji, Japan. In Mol Neurobiol, Oct 2015
PGD2, PGE2, and PGI2 exhibit neuroprotective effects via Gs-coupled DP1, EP2/EP4, and IP receptors, respectively.
The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.
Fabre et al., Paris, France. In Prostaglandins Other Lipid Mediat, Sep 2015
Through the activation of its receptor EP3, PGE2 sensitizes platelets to their agonists but also inhibits them through its two other receptors, EP2 and EP4.
Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection.
Kaech et al., New Haven, United States. In Nat Med, Apr 2015
We found that the prostaglandin E2 (PGE₂) receptors EP2 and EP4 were upregulated on virus-specific CTLs during chronic lymphocytic choriomeningitis virus (LCMV) infection and suppressed CTL survival and function.
The Prostaglandin Transporter: Eicosanoid Reuptake, Control of Signaling, and Development of High-Affinity Inhibitors as Drug Candidates.
Lu et al., United States. In Trans Am Clin Climatol Assoc, 2014
PGT knockout mice have elevated prostaglandin E2 (PGE2) and neonatal patent ductus arteriosus, which reflects PGT's control over PGE2 signaling at EP1/EP4 cell-surface receptors.
CCR7 Receptor Expression in Mono-MAC-1 Cells: Modulation by Liver X Receptor α Activation and Prostaglandin E 2.
Dumais et al., Sherbrooke, Canada. In Int J Inflam, 2014
In addition, our results demonstrate that engagement of the E-prostanoids 2 and 4 (EP2/EP4) receptors present on MM-1 cells is responsible for the observed increase in CCR7 mRNA expression and function during LXRα activation.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Zhong et al., Shanghai, China. In Nat Cell Biol, 2014
PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation.
Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
Divangahi et al., Montréal, Canada. In Immunity, 2014
Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype.
The prostanoid EP4 receptor and its signaling pathway.
Ishikawa et al., Yokohama, Japan. In Pharmacol Rev, 2013
The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2.
Differential stem- and progenitor-cell trafficking by prostaglandin E2.
Pelus et al., Indianapolis, United States. In Nature, 2013
PGE2 receptor knockout mice demonstrated that progenitor expansion and stem/progenitor egress resulted from reduced E-prostanoid 4 (EP4) receptor signalling.
Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model.
Lala et al., London, Canada. In Lab Invest, 2012
Tested the roles of COX-2 and EP receptors in VEGF-C and -D production by a highly metastatic COX-2 expressing murine breast cancer cell line C3L5.
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice.
Ushikubi et al., Asahikawa, Japan. In Kidney Int, 2012
An endogenous PGE(2)-EP(4) system in the tubular epithelium limits the development of tubulointerstitial fibrosis by suppressing inflammatory responses.
PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice.
Nüsing et al., Frankfurt am Main, Germany. In Diabetes, 2012
The data uncovered a previously unrecognized protective role of PTGS-2-derived PGE(2) in streptozotocin-induced diabetes mediated by PTGER2 and PTGER4.
The prostaglandin E₂ type 4 receptor participates in the response to acute oxidant stress in airway epithelial cells.
Cowley et al., Halifax, Canada. In J Pharmacol Exp Ther, 2012
With HO as a model oxidant stress, stimulation of CFTR seems to involve PGE production and likely EP receptor activation in Calu-3 airway epithelial cells.
MicroRNA-101 (miR-101) post-transcriptionally regulates the expression of EP4 receptor in colon cancers.
Nelson et al., Tucson, United States. In Cancer Biol Ther, 2012
EP-4 receptor expression is modulated at the post-transcriptional level by miR-101.
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