GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Prostaglandin E receptor 3
EP3
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] (from
NCBI)
Sponsored links
Top mentioned proteins:
EP1, EP2, EP4, V1a, cyclooxygenase
Papers using
EP3
antibodies
Ultrasound induces cyclooxygenase-2 expression through integrin, integrin-linked kinase, Akt, NF-kappaB and p300 pathway in human chondrocytes
Supplier
In Molecular Cancer, 2006
... , SC19220 and rabbit polyclonal antibody specific for COX-2, EP1 and EP3 were purchased from Cayman Chemical (Ann Arbor, MI) ...
Papers on
EP3
Altered expression and signalling of EP2 receptor in nasal polyps of AERD patients: role in inflammation and remodelling.
New
Barcelona, Spain. In Rhinology, Feb 2016
RESULTS: NM-C and NP-AERD samples and fibroblasts expressed EP2, EP3 and EP4 at baseline.
EP3, Prostaglandin E2 Receptor Subtype 3, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
New
Nantong, China. In Cell Mol Neurobiol, Jan 2016
UNASSIGNED: EP3 is prostaglandin E2 receptor subtype 3 and mediates the activation of several signaling pathways, changing in cAMP levels, calcium mobilization, and activation of phospholipase C. Previous studies demonstrated a direct role for EP3 in various neurodegenerative disorders, such as stroke and Alzheimer disease.
Discovery of highly potent dual EP2 and EP3 agonists with subtype selectivity.
New
Ōsaka, Japan. In Bioorg Med Chem Lett, Jan 2016
UNASSIGNED: The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-propenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (7) were identified as the first potent dual EP2 and EP3 agonists with selectivity against the EP1 and EP4 subtypes.
A Novel Dual Agonist of EP3 and FP Receptors for OAG and OHT: Safety, Pharmacokinetics, and Pharmacodynamics of ONO-9054 in Healthy Volunteers.
New
Ōsaka, Japan. In Invest Ophthalmol Vis Sci, Jan 2016
PURPOSE: The use of a dual prostaglandin E3 (EP3) and prostaglandin F (FP) receptor agonist is a novel approach for the reduction of intraocular pressure (IOP) in open angle glaucoma and ocular hypertension and, as such, ONO-9054 may have benefits over existing therapies.
Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.
Review
New
Kyoto, Japan. In Cornea, Nov 2015
Moreover, HLA-A*02:06 with TLR3 polymorphisms and HLA-A*02:06 with EP3 polymorphisms exerted additive effects in SJS/TEN with SOCs.
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Review
New
Cork, Ireland. In Br J Pharmacol, Nov 2015
The biological effects of PGE2 are mediated by signalling through four distinct E-type prostanoid (EP) receptors - EP1 , EP2 , EP3 and EP4 .
Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury.
New
Baltimore, United States. In J Cereb Blood Flow Metab, Nov 2015
UNASSIGNED: Prostaglandin E2 EP3 receptor is the only prostaglandin E2 receptor that couples to multiple G-proteins, but its role in thrombin-induced brain injury is unclear.
The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.
Review
New
Paris, France. In Prostaglandins Other Lipid Mediat, Sep 2015
Through the activation of its receptor EP3, PGE2 sensitizes platelets to their agonists but also inhibits them through its two other receptors, EP2 and EP4.
The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors.
Review
New
London, United Kingdom. In Prostaglandins Other Lipid Mediat, Jul 2015
This review discusses evidence that the pharmacology of each prostacyclin (IP) receptor agonist so far developed is distinct, with non-IP receptor targets clearly contributing to the therapeutic and side effect profile of PGI2 (EP3), iloprost (EP1), treprostinil (EP2, DP1) along with a family of nuclear receptors known as peroxisome proliferator-activated receptors (PPARs), to which PGI2 and some analogues directly bind.
Regulatory mechanism of the gastric hyperemic response following barrier disruption: roles of cyclooxygenase-1, the prostaglandin E2/EP1 receptor and sensory neurons.
Review
Kyoto, Japan. In Curr Pharm Des, 2014
The GMBF responses induced by TC were similarly observed in the stomachs of wild-type mice and EP3 receptor knockout mice, but not in mice lacking the EP1 receptor or pretreated with an EP1 antagonist.
Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes.
GeneRIF
In J Allergy Clin Immunol, 2012
epistatic interaction with prostaglandin E receptor 3 gene confers an increased risk for Stevens-Johnson syndrome with severe ocular surface complications
Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia.
GeneRIF
Los Angeles, United States. In Psychiatry Res, 2012
The levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased in patient with schizophrenia.
Prostaglandin E₂ induced contraction of human intercostal arteries is mediated by the EP₃ receptor.
GeneRIF
Paris, France. In Eur J Pharmacol, 2012
Prostaglandin E2 induced contraction of human intercostal arteries is mediated by the EP3 receptor
The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.
GeneRIF
London, United Kingdom. In J Clin Endocrinol Metab, 2012
EP3 is the primary receptor subtype that mediates PGE(2) induced contractility in human pregnant myometrium at term and represents a possible therapeutic target.
Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
GeneRIF
Stockholm, Sweden. In Plos One, 2011
Neuroblastoma express all four forms of PGE(2) receptors.
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Impact
Berkeley, United States. In Nat Med, 2009
AdPLA-null mice have a markedly higher rate of lipolysis owing to increased cyclic AMP levels arising from the marked reduction in the amount of adipose prostaglandin E(2) that binds the Galpha(i)-coupled receptor, EP3.
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.
Impact
GeneRIF
Kyoto, Japan. In Nat Immunol, 2005
PGE(2)-EP3 pathway is an important negative modulator of allergic reactions
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice.
Impact
Tokyo, Japan. In Nat Med, 2001
Homozygous gene knockout for other PGE(2) receptors, EP1 or EP3, did not affect intestinal polyp formation in Apc(Delta 716) mice.
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.
Impact
Kyoto, Japan. In Nature, 1998
PGE2 acts by interacting with four subtypes of PGE receptor, the EP1, EP2, EP3 and EP4 receptors.
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.
Impact
Kyoto, Japan. In Nature, 1993
Cell surface receptors for prostanoids have been characterized pharmacologically and the complementary DNAs for thromboxane A2 receptor and the EP3 subtype of the prostaglandin (PG)E receptor reveal that they belong to the seven-transmembrane-domain receptor family.
