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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Eomesodermin homolog

Eomes, Tbr2
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: T-bet, CD8, BET, FATE, CAN
Papers using Eomes antibodies
Papers on Eomes
CRISPR/Cas9-induced disruption of gene expression in mouse embryonic brain and single neural stem cells in vivo.
Sarov et al., Dresden, Germany. In Embo Rep, Feb 2016
Finally, we used either Cas9 plasmid in utero electroporation or Cas9 protein complex microinjection to disrupt the expression of Eomes/Tbr2, a gene fundamental for neocortical neurogenesis.
The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies.
Booth et al., Sydney, Australia. In Clin Immunol, Feb 2016
We previously identified that expression of two MS-risk genes, the transcription factors EOMES and TBX21 (ET), was low in blood from MS and stable over time.
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.
Greber et al., Münster, Germany. In Cell Stem Cell, Jan 2016
BMP signaling promotes miRNA-877 maturation to induce SOX2 mRNA degradation, while WNT-driven EOMES induction transcriptionally represses SOX2.
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Carbone et al., Melbourne, Australia. In Immunity, Jan 2016
We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling.
Ethanol induces cytostasis of cortical basal progenitors.
Mahimainathan et al., Lubbock, United States. In J Biomed Sci, Dec 2015
RESULTS: E18 neuroblasts expressing Tbr2 representing immature basal progenitors displayed significant reduction of proliferation in response to ethanol in both the models.
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates.
Chang et al., San Diego, United States. In Sci Rep, Dec 2015
However, unlike CD8(+) T cells deficient in only one aPKC isoform, complete loss of aPKC unexpectedly increased CD8(+) T cell differentiation toward a short-lived, terminal effector fate, as evidenced by increased rates of apoptosis and decreased expression of Eomes and Bcl2 early during the immune response.
Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells.
Buganim et al., Jerusalem, Israel. In Cell Stem Cell, Dec 2015
Here, we show that transient expression of Gata3, Eomes, and Tfap2c in mouse fibroblasts induces stable, transgene-independent trophoblast stem-like cells (iTSCs).
Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.
Schorle et al., Bonn, Germany. In Cell Stem Cell, Dec 2015
Here, we show that transient expression of Tfap2c, Gata3, Eomes, and Ets2 is sufficient to reprogram mouse embryonic fibroblasts and post-natal tail-tip-derived fibroblasts into induced TSCs (iTSCs) and surmount the epigenetic barrier separating somatic from extra-embryonic lineages.
Hobit and human effector T-cell differentiation: The beginning of a long journey.
Thiel et al., Berlin, Germany. In Eur J Immunol, Oct 2015
Hobit may initially appear as another "player" in the quest for transcription factors guiding T-cell differentiation; the discoveries of T-bet, Eomes, Blimp-1, and others have significantly contributed to our understanding of how this process is tightly regulated.
Molecular biology of the stress response in the early embryo and its stem cells.
Rappolee et al., Detroit, United States. In Adv Exp Med Biol, 2014
Some of the transcription factors (TFs) that are most important in the stress response are JunC, JunB, MAPKAPs, ATF4, XBP1, Oct1, Oct4, HIFs, Nrf2/KEAP, NFKB, MT1, Nfat5, HSF1/2 and potency-maintaining factors Id2, Cdx2, Eomes, Sox2, Nanog, Rex1, and Oct4.
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence.
Arnold et al., Freiburg, Germany. In Stem Cells Int, 2014
Here, we analysed the expression of key TSC transcription factors Cdx2, Eomes, and Elf5 in the early developing placenta of mouse embryos and in cultured TSCs and reveal surprising heterogeneity in protein levels.
Tumor-to-background ratio to predict response to chemotherapy of osteosarcoma better than standard uptake values.
Guo et al., Wuhan, China. In Orthop Surg, 2014
RESULTS: It was found that good responses are achieved in patients with TBR after chemotherapy (TBR2)/TBR before chemotherapy (TBR1) < 0.470 (positive predictive value [PPV] = 92.31%,
Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.
Hamilton et al., Minneapolis, United States. In Immunity, 2013
We show that a population of CD8⁺ T cells bearing markers associated with effector cells (KLRG1(hi), CD27(lo), T-bet(hi), Eomes(lo)) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses.
Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.
Yoshihara et al., Saitama, Japan. In J Neurosci, 2012
This study suggested that Tbr2 is required for the proper differentiation of mitral, tufted cells and for the establishment of functional neuronal circuitry in the OB, maintenance of excitatory-inhibitory balance crucial for odor information processing.
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.
Negrin et al., Stanford, United States. In Blood, 2012
Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells.
Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4(+) Th cells cytotoxic by activating both perforin- and FasL-pathways.
Shinohara et al., Sagamihara, Japan. In Immunol Lett, 2012
Eomes expression converts the functions of fully differentiated Th cells toward those of CTL by eliciting perforin and fasl expression.
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Rocha et al., Paris, France. In Blood, 2012
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons.
Hevner et al., Seattle, United States. In J Neurosci, 2012
These findings suggest that Tbr2 expression in INPs is critical for neuronal differentiation in the dentate gyrus and that INPs are an essential stage in the lineage from NSCs to new granule neurons in the dentate gyrus.
Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review.
Wullimann, Martinsried, Germany. In Integr Zool, 2009
Further topological correspondences are seen in the expression of LIM and homeobox genes, such as Lhx6/7, Tbr2 and Dlx2a.
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects.
Iannetti et al., Roma, Italy. In Acta Paediatr, 2009
Gene mutations linked to this disorder are SRPX2, PAX6, TBR2, KIAA1279, RAB3GAP1 and COL18A1.
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