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Endogenous retrovirus group W, member 1

Envelope Protein, Env
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CD4, CAN, gp120, CD45, HAD
Papers on Envelope Protein
Structural Organization of Baculovirus Occlusion Bodies and Protective Role of Multilayered Polyhedron Envelope Protein.
Hinchigeri et al., India. In Food Environ Virol, Feb 2016
The OB is an organized structure, chiefly composed of proteins namely polyhedrin, polyhedron envelope protein (PEP) and P10.
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
Robert-Guroff et al., Bethesda, United States. In J Immunol, Feb 2016
In this study, we quantified SIV Env-specific IL-21-producing TFH cells for the first time, to our knowledge, in a nonhuman primate vaccine study.
Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles.
Xia et al., Beijing, China. In J Immunol, Feb 2016
In this study, we investigated the binding of several equine infectious anemia virus-derived epitope peptides by the ability to refold recombinant molecules and by thermal stability, and then by determining the x-ray structure of five peptide-MHC I complexes: equine MHC class I allele (Eqca)-N*00602/Env-RW12, Eqca-N*00602/Gag-GW12, Eqca-N*00602/Rev-QW11, Eqca-N*00602/Gag-CF9, and Eqca-N*00601/Gag-GW12.
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
Poignard et al., Atlanta, United States. In Plos Pathog, Jan 2016
A correlation with high overall plasma IgG levels and anti-Env IgG binding titers was also found.
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
Sanders et al., Amsterdam, Netherlands. In Cell, Jan 2016
The envelope glycoprotein trimer mediates HIV-1 entry into cells.
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Wilson et al., Los Angeles, United States. In Immunity, Jan 2016
The high-mannose patch on the HIV-1 envelope (Env) glycoprotein is the epicenter for binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for generating such antibodies by vaccination have not been defined.
The HIV glycan shield as a target for broadly neutralizing antibodies.
Doores, London, United Kingdom. In Febs J, Dec 2015
The HIV envelope glycoprotein (Env) is the sole target for HIV broadly neutralizing antibodies (bnAbs).
Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease.
Sacha et al., Beaverton, United States. In Retrovirology, Dec 2015
From macaque cells we isolated a spliced mRNA product encoding SERV-K1 Env, which possesses all the structural features of a canonical, functional retroviral Envelope protein.
Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine Design.
Burton et al., Los Angeles, United States. In Immunity, Dec 2015
Broadly neutralizing antibodies (bnAbs) directed to the V2 apex of the HIV envelope (Env) trimer isolated from individual HIV-infected donors potently neutralize diverse HIV strains, but strategies for designing immunogens to elicit bnAbs have not been identified.
Human immunodeficiency virus/acquired immune deficiency syndrome: Using drug from mathematical perceptive.
Roy et al., Calcutta, India. In World J Virol, Dec 2015
These components may be categorized as attachment of the viral surface envelope protein subunit, gp120, to the CD4(+) receptor and chemokine coreceptors, CCR5 and CXCR4, present on T cell surface.
Baton pass hypothesis: successive incorporation of unconserved endogenous retroviral genes for placentation during mammalian evolution.
Miyazawa et al., Tokyo, Japan. In Genes Cells, Oct 2015
Syncytin 1 and syncytin 2 in humans and syncytin A and syncytin B in mice are membrane proteins originating from Env genes of ERVs.
Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.
Bjorkman et al., Pasadena, United States. In Cell, Oct 2015
The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs); thus, most neutralizing antibodies are strain specific.
Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.
Schuitemaker et al., Boston, United States. In Science, Aug 2015
In this study, we evaluated the protective efficacy of adenovirus serotype 26 (Ad26) vector priming followed by purified envelope (Env) glycoprotein boosting.
Inside the Envelope: Endogenous Retrovirus-K Env as a Biomarker and Therapeutic Target.
Douville et al., Winnipeg, Canada. In Front Microbiol, 2014
Additionally, there is a small body of research suggesting that ERVK Env has been domesticated for use in placental development, akin to the ERVW syncytin.
Vaccinia Virus LC16m8∆ as a Vaccine Vector for Clinical Applications.
Shida et al., Tokyo, Japan. In Vaccines (basel), 2013
Moreover, LC16m8∆ expressing HIV-1 Env in combination with a Sendai virus vector induced the production of anti-Env antibodies and CD8⁺ T-cells.
Silencing of endogenous envelope genes in human choriocarcinoma cells shows that envPb1 is involved in heterotypic cell fusions.
Rossi et al., Duarte, United States. In J Gen Virol, 2012
The role of syncytin-1 and Pb1 in cell-cell fusion was studied using lentiviral vectors that express short hairpin RNAs for stable knockdown of both genes.
Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.
Strick et al., Erlangen, Germany. In J Cell Biochem, 2012
proposed that Syncytin-1 is regulated by PPARgamma/RXRalpha signaling during placentogenesis to drive multinuclear syncytiotrophoblast layer formation and maintenance.
Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1.
Abrahams et al., Manchester, United Kingdom. In Immunology, 2012
The findings suggested that syncytin 1 is shed from the placenta into the maternal circulation in association with placental microvesicles, and modulates immune cell activation and the responses of immune cells to lipopolysaccharide stimulation.
Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin.
Hejnar et al., Praha, Czech Republic. In Nucleic Acids Res, 2011
Analysis of non-spliced ERVWE1 mRNAs and env mRNAs detected efficient splicing of endogenously expressed RNAs in trophoblastic but not in non-placental cells.
Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
Akiyama et al., Tokyo, Japan. In Nat Commun, 2010
Data show that beta-catenin/BCL9-Like (BCL9L)/T-cell factor 4 (TCF4) signalling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of human choriocarcinoma cells.
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