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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Endothelin 1

endothelin-1, endothelin, ET-1
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, Angiotensin II, AGE
Papers using endothelin-1 antibodies
Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats
Maeda Shiro, In PLoS ONE, 2010
... Rabbit polyclonal anti-ET-1 (American Research Products, Belmont, MA, USA), anti-Af9 (Bethyl Laboratory, Montgomery, TX, USA), ...
Endothelial dysfunction and vascular disease
Granstam Elisabet et al., In The Journal of Physiological Sciences, 2008
... Endothelin-1 (human; Bachem UK, UK) was dissolved ...
Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice
Hocher B et al., In European Journal of Medical Research, 2003
... For our study only male human-ET-1 transgenic mice were used ...
Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines
Papandreou Christos N et al., In Cancer Cell International, 2001
... ET-1 peptide and ETAR antagonist (BQ-123) were purchased from Phoenix Pharmaceuticals, Inc, Germany ...
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Papers on endothelin-1
Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-mediated Contractility via Activation of Focal Adhesion Kinase and Extra Cellular-regulated Kinase 1/2 in Cerebral Arteries from Rat.
Edvinsson et al., Glostrup, Denmark. In Basic Clin Pharmacol Toxicol, Feb 2016
UNASSIGNED: Cerebral ischaemia results in enhanced endothelin B (ETB ) receptor-mediated contraction and receptor protein expression in the affected cerebrovascular smooth muscle cells (SMC).
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
Gulati, Downers Grove, United States. In Curr Neuropharmacol, Feb 2016
UNASSIGNED: The ET family consists of three isopeptides (ET-1, ET-2 and ET-3) that produce biological actions by acting on two types of receptors (ETA and ETB).
Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: a physiological implication in bovine oviduct immunity.
Miyamoto et al., Obihiro, Japan. In J Reprod Dev, Feb 2016
Oviductal contractions are regulated by autocrine/paracrine secretion of several factors, such as prostaglandins (PGs) and endothelin-1 (EDN-1).
Mechanisms and Treatment of Intradialytic Hypertension.
Inrig et al., Dallas, United States. In Blood Purif, Feb 2016
Acute intradialytic changes in endothelial cell function have been proposed as etiologies for the increase in vascular resistance, although it is unclear if endothelin-1 or some other vasoconstrictive peptide is responsible.
Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide.
Leach et al., Buffalo, United States. In Semin Perinatol, Feb 2016
Oral pulmonary vasodilators such as endothelin receptor antagonist bosentan and phosphodiesterase-5 inhibitors such as sildenafil and tadalafil are used both during acute and chronic phases of PPHN.
Netrin-1 prevents the development of cardiac hypertrophy and heart failure.
Zhu et al., Lanzhou, China. In Mol Med Report, Feb 2016
Neonatal rat cardiomyocytes were stimulated with endothelin-1 (ET-1), and samples were collected to examine the expression levels of netrin‑1 by western blot analysis and the mRNA expression of A‑type natriuretic peptide by reverse transcription‑quantitative polymerase chain reaction.
The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia.
Danser et al., Rotterdam, Netherlands. In Ther Adv Cardiovasc Dis, Feb 2016
Both in cancer patients treated with sunitinib and in pregnant women with PE, significant rises in endothelin-1 occur.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Selexipag for the Treatment of Pulmonary Arterial Hypertension.
GRIPHON Investigators et al., Le Kremlin-Bicêtre, France. In N Engl J Med, Jan 2016
Patients were eligible for enrollment if they were not receiving treatment for pulmonary arterial hypertension or if they were receiving a stable dose of an endothelin-receptor antagonist, a phosphodiesterase type 5 inhibitor, or both.
AMBITION: An important piece in the therapeutic puzzle of pulmonary arterial hypertension.
Said, Aswān, Egypt. In Glob Cardiol Sci Pract, 2014
It is believed that simultaneous targeting of two or more of the three pathogenic pathways of pulmonary arterial hypertension (the endothelin, nitric oxide, and prostacyclin pathways) is associated with additive or synergistic effects with subsequent increasing efficacy and improving outcomes.
Acute Myocardial Response to Stretch: What We (don't) Know.
Leite-Moreira et al., Porto, Portugal. In Front Physiol, 2014
Calcium-dependent pathways, including angiotensin- and endothelin-related pathways; and cGMP-dependent pathways, comprising the effects of nitric oxide and cardiac natriuretic hormones, embody downstream signaling.
An O2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hypoxia.
López-Barneo et al., Sevilla, Spain. In Cell, 2014
Rather, mature glomus cells expressing endothelin-1, the O2-sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth.
Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.
Simpson et al., San Francisco, United States. In Pharmacol Rev, 2013
Alpha1-ARs signal through Gαq, and signaling through Gq, for example, by endothelin and angiotensin receptors, is thought to be detrimental to the heart.
Endothelin 1 in cancer: biological implications and therapeutic opportunities.
Bagnato et al., Roma, Italy. In Nat Rev Cancer, 2013
Activation of autocrine and paracrine signalling by endothelin 1 (ET1) binding to its receptors elicits pleiotropic effects on tumour cells and on the host microenvironment.
Macitentan and morbidity and mortality in pulmonary arterial hypertension.
SERAPHIN Investigators et al., Mexico. In N Engl J Med, 2013
We assessed the efficacy of macitentan, a new dual endothelin-receptor antagonist, using a primary end point of morbidity and mortality in a long-term trial.
Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia.
Iadecola et al., Ithaca, United States. In Hypertension, 2012
Data show that chronic intermittent hypoxia (CIH) markedly increased endothelin 1 in cerebral blood vessels.
Progressive retinal degeneration in transgenic mice with overexpression of endothelin-1 in vascular endothelial cells.
So et al., Hong Kong, Hong Kong. In Invest Ophthalmol Vis Sci, 2012
Transgenic mice models with overexpression of endothelin-1 may be useful when studying the mechanisms in vascular-associated retinal degenerative diseases.
The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns.
Finderle et al., Rijeka, Croatia. In Coll Antropol, 2012
Positive correlation between body mass index and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases.
Correlation of endothelin-1 concentration and angiotensin-converting enzyme activity with the staging of liver fibrosis.
Banić et al., Zagreb, Croatia. In Coll Antropol, 2012
Positive correlation between serum ACE activity and ET-1 concentration might indicate their interaction in the development of liver cirrhosis.
[Interaction of mutations M235T of the gene for angiotensinogen and Taq I 8,000 in the gene for endothelin-1 at the onset of essential hypertension].
Vácha et al., Brno, Czech Republic. In Cas Lek Cesk, 2000
Interaction of two polymorphic genetic variants of angiotensinogen and endothelin-1 genes was found
More papers using endothelin-1 antibodies
Caspases: the proteases of the apoptotic pathway
Fei Wang et al., In Mediators of Inflammation, 1997
... The serum Endothelin-1 ELA kit (ET-1) was purchased from Cayman chemical company (Mich, USA) (catalog ...
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