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Zinc finger, FYVE domain containing 16

Endofin, ZFYVE16, endosome-associated FYVE-domain protein endofin
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004 [PubMed 14613930]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sar1, HAD, Smad2, CAN, ACID
Papers on Endofin
Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.
Zhang et al., Hefei, China. In Nat Commun, 2014
We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27
Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin.
Subramaniam et al., Brisbane, Australia. In Sci Rep, 2014
We examined the role of endofin, a SMAD anchor, and show that knockdown of endofin in liver cells inhibits basal and BMP-induced hepcidin expression along with other BMP-regulated genes, ID1 and SMAD7.
The influence of surface microroughness and hydrophilicity of titanium on the up-regulation of TGFβ/BMP signalling in osteoblasts.
Ivanovski et al., Gold Coast, Australia. In Biomaterials, 2011
Pathway analysis demonstrated that a number of genes associated with the TGFβ‑BMP signalling cascade (BMP2, BMP6, SP1, CREBBP, RBL2, TBS3, ACVR1 and ZFYVE16) were significantly differentially up-regulated with culture on the modSLA surface.
EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes.
Lim et al., Singapore, Singapore. In Cell Signal, 2010
Disruption of proper localization to the endosomes and the Y515 phosphorylation of Endofin enhanced MAPK activation suggesting that Endofin negatively modulates EGFR signaling following receptor endocytosis.
Sustained BMP signaling in osteoblasts stimulates bone formation by promoting angiogenesis and osteoblast differentiation.
Cao et al., Birmingham, United States. In J Bone Miner Res, 2009
We recently identified endosome-associated FYVE-domain protein (endofin) as a Smad anchor for BMP receptor activation.
Isolation of cross-reacting antigen candidates by mRNA-display using a mixed cDNA library.
Shiratori et al., Yokohama, Japan. In Biotechnol Lett, 2008
After several rounds of panning, five annotated polypeptides, topoisomeraseII-binding protein 1 (TOBP1), RAS protein activator like 2 isoform 1 (RASAL2), endosome-associated FYVE-domain protein (ZFYVE16), and utrophin (UTRN) as well as hTP53, were identified as cross-reactive antigen candidates.
Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.
Lim et al., Singapore, Singapore. In Proteomics, 2007
our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network
Endofin acts as a Smad anchor for receptor activation in BMP signaling.
Cao et al., Birmingham, United States. In J Cell Sci, 2007
Here we report for the first time that the endosome-associated FYVE-domain protein endofin acts as a Smad anchor for receptor activation in BMP signaling.
Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.
Lu et al., Beijing, China. In J Biol Chem, 2007
Facilitates TGF-beta signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing Smad4 to the proximity of the receptor complex.
Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.
Hoffmann et al., Madison, United States. In Mol Biol Cell, 2006
The key mode of action of Trx-SARA was to reduce the level of Smad2 and Smad3 in complex with Smad4 after TGF-beta1 stimulation.
[Changes of gene expression profile of multiple myeloma cell line RPMI 8226 treated by arsenic trioxide].
Liu et al., Xi'an, China. In Zhong Xi Yi Jie He Xue Bao, 2006
ZFYVE16, ALK1 and TXNIP genes may play important roles in apoptosis and differentiation of RPMI 8226 cells.
Endofin recruits clathrin to early endosomes via TOM1.
Hong et al., Singapore, Singapore. In J Cell Sci, 2005
We have recently shown that endofin, a FYVE domain protein associated with the early endosome, is able to recruit cytosolic TOM1 onto endosomal membranes.
Endofin recruits TOM1 to endosomes.
Hong et al., Singapore, Singapore. In J Biol Chem, 2004
marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment
Endofin, an endosomal FYVE domain protein.
Hong et al., Singapore, Singapore. In J Biol Chem, 2001
We have tentatively called KIAA0305 endofin (for endosome-associated FYVE-domain protein).
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