GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Mannose receptor, C type 2
Endo180, novel lectin, uPARAP, MRC2, CD280
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012] (from
NCBI)
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ACID, fibrillin-1, CAN, HAD, Plasminogen
Papers on
Endo180
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
New
Copenhagen, Denmark. In J Pathol, Jan 2016
The endocytic collagen receptor, uPARAP/Endo180, is expressed on various mesenchymal cell types and is involved in bone matrix turnover during normal bone growth.
A novel vasorelaxant lectin purified from seeds of Clathrotropis nitida: partial characterization and immobilization in chitosan beads.
New
Fortaleza, Brazil. In Arch Biochem Biophys, Jan 2016
A novel lectin from seeds of Clathrotropis nitida (CNA) was purified and characterized.
Endo180 at the cutting edge of bone cancer treatment and beyond.
Review
New
Kingston upon Hull, United Kingdom. In J Pathol, Dec 2015
For the first time they have demonstrated that a mouse monoclonal antibody targeting the collagen receptor Endo180 (CD280, MRC2, uPARAP) can prevent osteolysis and bone destruction in a syngeneic model of advanced osteosarcoma.
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.
New
New York City, United States. In Clin Exp Metastasis, Dec 2015
Here we present a model that uses human stromal cell-derived matrices to demonstrate that plasticity in tumor cell movement is controlled by the tumor-associated collagen receptor Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) and the crosslinking of collagen fibers by stromal-derived lysyl oxidase (LOX).
Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1-4.
New
London, United Kingdom. In Structure, Dec 2015
The C-type mannose receptor and its homolog Endo180 (or uPARAP, for urokinase plasminogen activator receptor-associated protein) mediate the endocytic uptake of collagen by macrophages and fibroblasts.
Expression and crystallographic studies of the ligand-binding region of the human endocytic collagen receptor uPARAP.
New
Fuzhou, China. In Acta Crystallogr Sect F Struct Biol Commun, Dec 2015
Urokinase plasminogen activator receptor-associated protein (uPARAP) is an endocytic receptor that internalizes collagen for lysosomal degradation and plays an important role in matrix remodelling.
Purification and molecular characterization of a novel mannose-specific lectin from Dioclea reflexa hook seeds with inflammatory activity.
New
Fortaleza, Brazil. In J Mol Recognit, Nov 2015
UNASSIGNED: A novel lectin present in Dioclea reflexa seeds (DrfL) was discovered and described in this study.
The collagen receptor uPARAP/Endo180 in tissue degradation and cancer (Review).
Review
New
Copenhagen, Denmark. In Int J Oncol, Oct 2015
The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells.
Tyrosine kinase inhibitors: New class of antimalarials on the horizon?
New
Mumbai, India. In Blood Cells Mol Dis, Aug 2015
Antimalarial activity was tested with the help of modified WHO microtest technique in-vitro for five different Plasmodium falciparum laboratory strains (3D7, Dd2, 7G8, MRC2, PKL9).
Genome-Wide Architecture of Disease Resistance Genes in Lettuce.
Davis, United States. In G3 (bethesda), 2014
MRC2 spans 73 Mb and contains 61 NLRs of six different gene families that cosegregate with nine disease resistance phenotypes.
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.
Yokohama, Japan. In Mar Drugs, 2014
MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc).
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Shenzhen, China. In Nat Commun, 2014
Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2.
Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis.
GeneRIF
Copenhagen, Denmark. In J Pathol, 2012
This function of uPARAP/Endo180 defines a novel role of intracellular collagen turnover in fibrosis protection.
TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
GeneRIF
London, United Kingdom. In J Pathol, 2012
TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.
Role of urokinase plasminogen activator receptor-associated protein in mouse lung.
GeneRIF
Seattle, United States. In Am J Respir Cell Mol Biol, 2012
uPARAP is highly expressed in the murine lung, and loss of uPARAP leads to differences in lung mechanics, lung permeability, and collagen content after injury
Mannose receptor 2 attenuates renal fibrosis.
GeneRIF
Seattle, United States. In J Am Soc Nephrol, 2012
data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
GeneRIF
Copenhagen, Denmark. In J Biol Chem, 2011
A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.
The collagen receptor uPARAP/Endo180.
Review
Copenhagen, Denmark. In Front Biosci, 2008
The uPAR-associated protein (uPARAP/Endo180), a type-1 membrane protein belonging to the mannose receptor family, is an endocytic receptor for collagen.
Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates.
Review
Baltimore, United States. In Curr Opin Struct Biol, 2004
Although representatives of lectin families typical of mammals, such as C-type lectins, galectins and pentraxins, have been described in these taxa, the detailed study of selected model species has yielded either novel variants of the structures described for the mammalian lectin representatives or novel lectin families with unique sequence motifs, multidomain arrangements and a new structural fold.
The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis.
Review
Little Rock, United States. In Can J Cardiol, 2004
Recently, a novel lectin-like receptor for ox-LDL (LOX-1) has been identified, primarily in the endothelial cells, that allows uptake of ox-LDL into endothelial cells.
