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Empty spiracles homolog 2

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009] (from NCBI)
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Top mentioned proteins: CAN, HAD, Pax6, HOXA10, AGE
Papers on Emx2
Identification and expression of the target gene emx2 of miR-26a and miR-26b in Paralichthys olivaceus.
Fu et al., Shanghai, China. In Gene, Nov 2015
And the gene empty spiracles homeobox 2 (emx2) was proposed to be a candidate target by bioinformatics prediction.
Schizencephaly-diagnostics and clinical dilemmas.
Gergont et al., Kraków, Poland. In Childs Nerv Syst, Apr 2015
The causes of schizencephaly are heterogeneous and can include teratogens, prenatal infection, maternal trauma, or EMX2 mutations.
Nonsense mutation of EMX2 is potential causative for uterus didelphysis: first molecular explanation for isolated incomplete müllerian fusion.
Chen et al., Jinan, China. In Fertil Steril, Mar 2015
OBJECTIVE: To investigate the association between human empty spiracles homeobox 2 gene (EMX2) and incomplete müllerian fusion (IMF).
A gene expression map of the larval Xenopus laevis head reveals developmental changes underlying the evolution of new skeletal elements.
Medeiros et al., Boulder, United States. In Dev Biol, Feb 2015
We noted a conspicuous change in dlx1/2 and emx2 expression in the second pharyngeal arch, presaging the differentiation of the reduced dorsal hyoid arch skeletal element typical of modern anamniote tetrapods.
EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas.
He et al., Tianjin, China. In Plos One, 2014
EMX2 is a homeo-domain containing transcription factor known to regulate a key developmental pathway.
Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.
Sachinidis et al., Köln, Germany. In Cell Death Dis, 2014
Analysis of the gene expression data showed that VPA repressed neural tube and dorsal forebrain (OTX2, ISL1, EMX2 and SOX10)-related transcripts.
Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10.
Cai et al., Ürümqi, China. In Evid Based Complement Alternat Med, 2014
Elevation of HOXA10 led to further upregulation of its target gene, integrin β3, and downregulation of EMX2, two additional markers of uterine receptivity.
The homeobox gene EMX2 is a prognostic and predictive marker in malignant pleural mesothelioma.
He et al., San Francisco, United States. In Lung Cancer, 2014
EMX2 is a homeobox transcription factor that may regulate key developmental pathways known to promote tumorigenesis.
Wnt signaling pathway in non-small cell lung cancer.
Stewart, Ottawa, Canada. In J Natl Cancer Inst, 2014
Downregulation of Wnt inhibitors (eg, by hypermethylation) is common in NSCLC tumor cell lines and resected samples; may be associated with high stage, dedifferentiation, and poor prognosis; and has been reported for AXIN, sFRPs 1-5, WIF-1, Dkk-1, Dkk-3, HDPR1, RUNX3, APC, CDX2, DACT2, TMEM88, Chibby, NKD1, EMX2, ING4, and miR-487b.
Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients.
O'Shea et al., Ann Arbor, United States. In Transl Psychiatry, 2013
Cells were responsive to dorsal/ventral patterning cues, as addition of the Hedgehog (ventral) pathway activator purmorphamine or a dorsalizing agent (lithium) stimulated expression of NKX2-1 (ventral identity) or EMX2 (dorsal) in both groups.
Subdivisions of the adult zebrafish pallium based on molecular marker analysis.
Brand et al., Dresden, Germany. In F1000res, 2013
Combinatorial expression analysis of ascl1a, eomesa, emx1, emx2, emx3, and Prox1 identifies four main divisions in the adult zebrafish pallium.
Rare somatic mutation and loss of expression of EMX2 gene in common solid cancers.
Lee et al., In Apmis, 2011
Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay.
Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
He et al., Tokyo, Japan. In Clin Lung Cancer, 2011
Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma.
Control of pelvic girdle development by genes of the Pbx family and Emx2.
Selleri et al., New York City, United States. In Dev Dyn, 2011
Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation.
Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter.
Chiquet-Ehrismann et al., Basel, Switzerland. In Bmc Dev Biol, 2010
Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1.
Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2.
Bouchard et al., Montréal, Canada. In Plos One, 2010
A high incidence of urinary tract anomalies in Pax2;Emx2 were found in compound heterozygous mice that are not found in single heterozygous mice.
Neuronal migration disorders: clinical, neuroradiologic and genetics aspects.
Iannetti et al., Roma, Italy. In Acta Paediatr, 2009
EMX2 gene could be implicated in its genesis.
Schizencephaly: clinical spectrum, epilepsy, and pathogenesis.
Battaglia et al., Milano, Italy. In J Child Neurol, 2005
Review of the genetic studies and the more recent personal data suggests that the role of the EMX2 gene in schizencephaly, if any, is restricted to a minority of cases, leaving the etiopathogenesis of this brain malformation still a matter of study and debate.
Neuronal migration disorders, genetics, and epileptogenesis.
Filippi et al., Pisa, Italy. In J Child Neurol, 2005
Initial reports of heterozygous mutations in the EMX2 gene have not been confirmed.
Genetic malformations of the cerebral cortex and epilepsy.
Guerrini, Pisa, Italy. In Epilepsia, 2004
Initial reports of heterozygous mutations in the EMX2 gene need confirmation.
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