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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Elastin microfibril interfacer 1

Emi, EMILIN-1, gp115, EMILIN
This gene encodes an extracellular matrix glycoprotein that is characterized by an N-terminal microfibril interface domain, a coiled-coiled alpha-helical domain, a collagenous domain and a C-terminal globular C1q domain. The encoded protein associates with elastic fibers at the interface between elastin and microfibrils and may play a role in the development of elastic tissues including large blood vessels, dermis, heart and lung. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: elastin, CD45, fibrillin-1, EMILIN2, CAN
Papers on Emi
Cover Image, Volume 37, Issue 1.
In Hum Mutat, Jan 2016
This mutation causes a reduction in extracellular matrix deposition, an increased cellular apoptosis, and an abnormal accumulation of EMILIN-1 in the endoplasmic reticulum.
Diagnostic Exome Sequencing Identifies a Novel Gene, EMILIN1, Associated with Autosomal-Dominant Hereditary Connective Tissue Disease.
Doliana et al., Italy. In Hum Mutat, Jan 2016
By performing trio-exome sequencing of a 55-year-old male proband presenting with multiple symptoms indicative of a connective disorder, we identified a heterozygous missense alteration in exon 1 of the Elastin Microfibril Interfacer 1 (EMILIN1) gene, c.64G>A (p.A22T).
Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart.
de Castro Brás et al., San Antonio, United States. In Proteomics Clin Appl, Jan 2016
RESULTS: Elastin microfibril interface-located protein 1 (EMILIN-1) decreased with age in WT (p < 0.05), but not in MMP-9 null.
Alcelaphine herpesvirus 1 glycoprotein B: recombinant expression and antibody recognition.
Russell et al., Shreveport, United States. In Arch Virol, Jan 2016
Cloning and expression of a haemagglutinin-tagged version of the AlHV-1 glycoprotein B (gB) was used to demonstrate that the AlHV-1-specific monoclonal antibody 12B5 recognised gB and that gB was the main component of the gp115 complex of AlHV-1, a glycoprotein complex of five components identified on the surface of AlHV-1 by immunoprecipitation and radiolabelling.
Distinct methylation profiles characterize fusion-positive and fusion-negative rhabdomyosarcoma.
Barr et al., Bethesda, United States. In Mod Pathol, Sep 2015
Notably, EMILIN1 (part of the 11-gene signature) showed higher methylation and lower mRNA expression in fusion-positive compared with fusion-negative tumors, and demonstrated demethylation and re-expression in multiple fusion-positive cell lines after treatment with 5-aza-2'-deoxycytidine.
In vitro elastogenesis: instructing human vascular smooth muscle cells to generate an elastic fiber-containing extracellular matrix scaffold.
Schenke-Layland et al., Stuttgart, Germany. In Biomed Mater, Jun 2015
Most interestingly, we identified the successful deposition of elastogenesis-associated proteins, including fibrillin-1 and -2, fibulin-4 and -5, fibronectin, elastin microfibril interface located protein 1 (EMILIN-1) and lysyl oxidase (LOX) within our engineered constructs.
Periostin and TGF-β-induced protein: Two peas in a pod?
Annis et al., Madison, United States. In Crit Rev Biochem Mol Biol, 2014
Periostin (PN) and TGF-β-induced protein (βig-h3) are paralogs that contain a single emilin and four fasciclin-1 modules and are secreted from cells.
Vascular smooth muscle Emilin-1 is a regulator of arteriolar myogenic response and blood pressure.
Lembo et al., Padova, Italy. In Arterioscler Thromb Vasc Biol, 2012
Emilin-1 produced by vascular smooth muscle cells acts as a main regulator of resting blood pressure levels by controlling the myogenic response in resistance arteries through TGF-beta.
CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.
Drescher et al., Detroit, United States. In Biochem J, 2012
Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 intracellular sequence that follows a predicted transmembrane domain in the C-terminus
Pooled analyses of the associations of polymorphisms in the GRK4 and EMILIN1 genes with hypertension risk.
Xi et al., Taizhou, China. In Int J Med Sci, 2011
There were significant associations of rs2011616 and rs2304682 polymorphisms in the EMILIN1 gene with hypertension among Japanese.
[Morphogenesis, structure and properties of lymphatic vessels].
Radomska-Leśniewska et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2011
Native lymphatic capillaries differ from blood capillaries by having an irregular lumen, a discontinuous basement membrane, absence of pericytes, and a strong anchorage of their endothelial cells to the extracellular matrix via microfibrils built of emilin and fibrillin.
EMILIN1-α4/α9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation.
Spessotto et al., Italy. In J Cell Biol, 2011
EMILIN1 is identified as a novel ligand for keratinocyte alpha9beta1 integrin, suggesting prospective roles for this receptor-ligand pair in skin homeostasis.
EMILIN-1 regulates the amount of oxytalan fiber formation in periodontal ligaments in vitro.
Ishikawa et al., Fukuoka, Japan. In Connect Tissue Res, 2011
EMILIN-1 may regulate the formation of oxytalan fibers and play a role in their homeostasis.
Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons.
Gaul et al., New York City, United States. In Cell, 2008
SIMU strongly binds to apoptotic cells, presumably through its EMILIN-like domain, but requires no membrane anchoring, suggesting that it can function as a bridging molecule.
Multimerin 1.
Hayward et al., Hamilton, Canada. In Platelets, 2008
Recently, multimerin 1 was designated as a member of the EMILIN protein family, a group of structurally similar, disulfide-linked multimeric proteins.
New insights into elastic fiber assembly.
Mecham et al., Saint Louis, United States. In Birth Defects Res C Embryo Today, 2007
Microfibrils consist mainly of fibrillin, but also contain or associate with proteins such as microfibril associated glycoproteins (MAGPs), fibulins, and EMILIN-1.
Cytostatic factor: an activity that puts the cell cycle on hold.
Mayer et al., Martinsried, Germany. In J Cell Sci, 2006
Recently, members of the novel Emi/Erp family of proteins have been put forward as important components of CSF.
TGF-beta regulation by Emilin1: new links in the etiology of hypertension.
Cobb et al., Dallas, United States. In Cell, 2006
In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-beta signaling.
Emilin1 links TGF-beta maturation to blood pressure homeostasis.
Bressan et al., Padova, Italy. In Cell, 2006
Here, we report an unprecedented link between TGF-beta signaling and arterial hypertension based on the analysis of mice mutant for Emilin1, a cysteine-rich secreted glycoprotein expressed in the vascular tree.
CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1.
Burakoff et al., Boston, United States. In Nature, 1991
THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes.
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