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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ELP3 Elp3p

Elp3, TOT3
ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009] (from NCBI)
Top mentioned proteins: Histone, POLYMERASE, CAN, Dys, N-acetyl-beta-D-glucosaminidase
Papers on Elp3
DNA damage induced by the anticodon nuclease from a Pichia acaciae killer strain is linked to ribonucleotide reductase depletion.
Meinhardt et al., Münster, Germany. In Cell Microbiol, Feb 2016
Consistently, prevention of tRNA cleavage in elp3 or trm9 mutants, which both affect the wobble uridine modification of the target tRNA, suppressed the toxin hypersensitivity of a dNTP synthesis mutant.
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Bone Mineral Density in Childhood Study BMDCS et al., Copenhagen, Denmark. In Hum Mol Genet, Feb 2016
We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23.
Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions.
Ottonello et al., Parma, Italy. In Nucleic Acids Res, Oct 2015
ELP3) and urmylation (e.g., NCS6) pathways.
Loss of anticodon wobble uridine modifications affects tRNA(Lys) function and protein levels in Saccharomyces cerevisiae.
Schaffrath et al., Kassel, Germany. In Plos One, 2014
However, an elp3 disruption strain displays synthetic sick interaction and synergistic temperature sensitivity when combined with either uba4 or urm1 mutations, suggesting major translational defects in the absence of mcm5s2U modifications.
ELP3 is involved in sexual and asexual development, virulence, and the oxidative stress response in Fusarium graminearum.
Lee et al., In Mol Plant Microbe Interact, 2014
We determined that the insertion occurred in a gene encoding an ortholog of yeast elongator complex protein 3 (ELP3).
Promoter hypermethylation may be an important mechanism of the transcriptional inactivation of ARRDC3, GATA5, and ELP3 in invasive ductal breast carcinoma.
Li et al., Chengdu, China. In Mol Cell Biochem, 2014
This study was to detect promoter methylation status and mRNA expression levels of ARRDC3, ELP3, GATA5, and PAX6, and to explore the association between methylation and expression in invasive ductal carcinomas (IDCs) and matched normal tissues (MNTs) from breast cancer patients.
HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release.
Verstreken et al., Leuven, Belgium. In Cell Rep, 2014
Consequently, reduced levels of HDAC6 or increased levels of ELP3, a Bruchpilot acetyltransferase, rescue the presynaptic density defects in TDP-43-expressing flies as well as the decreased adult locomotion.
Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress.
Ye et al., Shanghai, China. In Embo J, 2014
We also identified KAT9/ELP3 as a potential acetyltransferase of G6PD.
Design and synthesis of elastin-like polypeptides for an ideal nerve conduit in peripheral nerve regeneration.
Shieh et al., Taipei, Taiwan. In Mater Sci Eng C Mater Biol Appl, 2014
The study involves design and synthesis of three different elastin like polypeptide (ELP) gene monomers namely ELP1, ELP2 and ELP3 that encode for ELP proteins.
rRNA fragmentation induced by a yeast killer toxin.
Meinhardt et al., Münster, Germany. In Mol Microbiol, 2014
In contrast to the tRNA targeting toxins, however, neither a change of the wobble uridine modification status by introduction of elp3 or trm9 mutations nor tRNA overexpression rescued from PiOrf4 toxicity.
Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle.
Miller et al., Guelph, Canada. In Bmc Genet, 2013
The strongest association with RFI (P = 0.0017) was found with a newly discovered SNP located on BTA 8 within the ELP3 gene.
Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion.
Yang et al., Montréal, Canada. In J Biol Chem, 2013
In addition to Atat1, three other mammalian acetyltransferases, ARD1-NAT1, ELP3, and GCN5, have been shown to acetylate α-tubulin in vitro, so an important question is how these four enzymes contribute to the acetylation in vivo.
DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator.
Chariot et al., Liège, Belgium. In J Biol Chem, 2012
Our results show that DERP6/ELP5 is required for the integrity of Elongator and directly connects ELP3 to ELP4.
Suicidal ideation during antidepressant treatment: do genetic predictors exist?
Perroud, Genève, Switzerland. In Cns Drugs, 2011
In this perspective, several genetic predictors have been highlighted, the majority of which relate to common mechanisms of antidepressant action: genes involved in the neurotrophic and synaptic plasticity systems (CREB1, and BDNF and its receptor NTRK2), noradrenergic system (ADRA2A), glutamatergic system (GRIA3, GRIK2 and GDA), inflammatory and hypothalamic-pituitary-adrenal (HPA) axis systems (IL28RA and FKBP5) and in other brain functions (PAPLN, APOO, KCNIP4 and ELP3).
Arabidopsis thaliana, a plant model organism for the neuronal microtubule cytoskeleton?
Marc et al., Sydney, Australia. In J Exp Bot, 2011
A number of microtubule-associated proteins (MAPs) are conserved, including katanin, EB1, CLASP, spastin, gephyrin, CRIPT, Atlastin/RHD3, and ELP3.
Comparative studies of genome-wide maps of nucleosomes between deletion mutants of elp3 and hos2 genes of Saccharomyces cerevisiae.
Nishida et al., Tokyo, Japan. In Plos One, 2010
both Elp3-induced acetylation and Hos2-induced deacetylation influence the nucleosome positions in the promoters of 24 genes
hElp3 directly modulates the expression of HSP70 gene in HeLa cells via HAT activity.
Han et al., Xinxiang, China. In Plos One, 2010
data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function
The histone acetyltransferase Elp3 plays in active role in the control of synaptic bouton expansion and sleep in Drosophila.
Elefant et al., Philadelphia, United States. In J Neurochem, 2010
The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep.
The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression.
Harkness et al., Saskatoon, Canada. In Eukaryot Cell, 2010
We present our working model in which Elp3/Gcn5 and the APC work together to facilitate passage through mitosis and G(1). To progress into S, we propose that at least Gcn5 must then be targeted for degradation in an APC-dependent fashion.
Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.
Breunig et al., Halle, Germany. In Mol Microbiol, 2010
Results conclude that yeast and plant Elongator (elp3/ELO3) share tRNA modification roles and propose that this function might be conserved in Elongator from all eukaryotic kingdoms of life.
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