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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Engulfment and cell motility 1

ELMO1, CED-12, engulfment and cell motility 1, ELMO2
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: DOCK180, Akt, Rac1, Actin, CAN
Papers using ELMO1 antibodies
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation
Katoh Hironori et al., In The Journal of Cell Biology, 2006
... Millipore); a rat mAb against HA (3F10; Roche); a rabbit pAb against Myc (MBL); a goat pAb against ELMO2 (Abcam); control mouse IgG (Jackson ...
Papers on ELMO1
CC chemokine ligand 18(CCL18) promotes migration and invasion of lung cancer cells by binding to Nir1 through Nir1-ELMO1/DOC180 signaling pathway.
Zhang et al., Weifang, China. In Mol Carcinog, Feb 2016
In addition, CCL18 is capable of modulating cell migration and invasion by regulating the activation of RAC1 which resulted in cytoskeleton reorganization in an ELMO1 dependent manner.
Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients.
Fischer et al., Düsseldorf, Germany. In Leuk Res, Sep 2015
Eleven novel translocations involved the genes ART4, C12orf60, MACROD2, TBL1XR1, LRRN4, KIAA1467, and ELMO1/MIR1200.
An ELMO2-RhoG-ILK network modulates microtubule dynamics.
Dagnino et al., London, Canada. In Mol Biol Cell, Aug 2015
ELMO2 belongs to a family of scaffold proteins involved in phagocytosis and cell motility.
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.
Ravichandran et al., In J Clin Invest, Aug 2015
This pathway involves the phagocytic receptor brain-specific angiogenesis inhibitor 1 (BAI1), which recognizes phosphatidylserine on apoptotic cells, and the intracellular signaling intermediates engulfment cell motility 1 (ELMO1) and Rac1, as ABCA1 induction was attenuated in primary macrophages from mice lacking these molecules.
Recent progress in the genetics of diabetic microvascular complications.
Chuang et al., Taipei, Taiwan. In World J Diabetes, Jul 2015
However, most of the identified risk loci could not be replicated by independent studies with a few exceptions including those in ELMO1, FRMD3, CARS, MYO16/IRS2, and APOL3-MYH9 genes.
Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation.
Tanaka et al., Sapporo, Japan. In Cell Commun Signal, 2014
BACKGROUND: The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocytosis, and invasion of cancer cells.
Genetics of diabetes complications.
Lyssenko et al., Lund, Sweden. In Mamm Genome, 2014
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
Bass et al., Boston, United States. In Nat Genet, 2013
The new significantly mutated genes include chromatin-modifying factors and candidate contributors SPG20, TLR4, ELMO1 and DOCK2.
The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread.
Mitchell et al., Oxford, United Kingdom. In Clin Exp Metastasis, 2012
Over-expression of NELL1 is associated with alveolar rhabdomyosarcoma.
Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment.
Peterson et al., United States. In Curr Biol, 2012
findings suggest that clearance of apoptotic cells in living vertebrates is accomplished by the combined actions of apoptotic cell migration and elmo1-dependent macrophage engulfment
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Yokoyama et al., Yokohama, Japan. In Proc Natl Acad Sci U S A, 2012
The C-terminal Pro-rich tail of ELMO1 winds around the Src-homology 3 domain of DOCK2 to form an intermolecular 5-helix bundle. The entire regions of both DOCK2 a& ELMO1 assemble to create a rigid structure required for the DOCK2 & ELMO1 binding.
The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
Zhang et al., Taejŏn, South Korea. In J Biol Chem, 2011
The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
Phagocytic activity of neuronal progenitors regulates adult neurogenesis.
Kipnis et al., Charlottesville, United States. In Nat Cell Biol, 2011
Data show that intracellular engulfment protein ELMO1 was required for phagocytosis by DCX(+) cells.
Neuronal activity is required for the development of specific cortical interneuron subtypes.
Fishell et al., New York City, United States. In Nature, 2011
Furthermore, we show that the engulfment and cell motility 1 gene (Elmo1), a target of the transcription factor distal-less homeobox 1 (Dlx1), is selectively expressed in Re(+) and Cr(+) interneurons and is both necessary and sufficient for activity-dependent interneuron migration.
Genetics of diabetes complications.
Doria, Boston, United States. In Curr Diab Rep, 2010
Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropathy, and the ADIPOQ gene for coronary artery disease.
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo.
Ravichandran et al., Charlottesville, United States. In Nature, 2010
findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo
Susceptibility genes in common complex kidney disease.
Freedman et al., Winston-Salem, United States. In Curr Opin Nephrol Hypertens, 2010
RECENT FINDINGS: The role of renal failure susceptibility genes, including MYH9, ELMO1, UMOD and ACTN4, has become clearer over the past 18 months.
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
Hengartner et al., Stony Brook, United States. In Nature, 2005
In the first pathway, the proteins CED-2, CED-5 and CED-12 (mammalian homologues CrkII, Dock180 and ELMO, respectively) function to activate CED-10 (Rac1).
Programmed cell death.
Xue et al., United States. In Wormbook, 2004
The recognition and removal of the dying cell is mediated by two partially redundant signaling pathways involving CED-1, CED-6 and CED-7 in one pathway and CED-2, CED-5, CED-10, CED-12 and PSR-1 in the other pathway.
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