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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Elongation factor, RNA polymerase II, 2

Top mentioned proteins: POLYMERASE, CAN, MEN, MLL, Histone
Papers on ELL2
Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation.
Busslinger et al., Vienna, Austria. In Nat Immunol, Feb 2016
Blimp-1 induced the transcription of immunoglobulin genes by controlling the 3' enhancers of the loci encoding the immunoglobulin heavy chain (Igh) and κ-light chain (Igk) and, furthermore, regulated the post-transcriptional expression switch from the membrane-bound form of the immunoglobulin heavy chain to its secreted form by activating Ell2 (which encodes the transcription-elongation factor ELL2). Notably, Blimp-1 recruited chromatin-remodeling and histone-modifying complexes to regulate its target genes.
Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.
Sturgis et al., Houston, United States. In Cancer, Aug 2015
Meta-analysis of the non-Hispanic white and Hispanic cohorts identified another genome-wide significant SNP in ELL2 (meta-OR, 1.86; 95% CI, 1.48-2.34
Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats.
Yoshimura et al., Nagoya, Japan. In Prostate, Apr 2015
Significant upregulation of androgen receptor and androgen-responsive genes such as Eaf2, ELL2, FKBP5, calreticulin, and ornithine decarboxylase was observed in the LCM-dissected epithelium.
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
Nilsson et al., Lund, Sweden. In Nat Commun, 2014
Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25;
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Milcarek et al., Pittsburgh, United States. In J Immunol, 2014
The transcription elongation factor eleven nineteen lysine-rich leukemia gene (ELL2) stimulates the processing of the secreted form of the IgH mRNA from the H chain gene.
The transcription elongation factor ELL2 is specifically upregulated in HTLV-1-infected T-cells and is dependent on the viral oncoprotein Tax.
Kress et al., Erlangen, Germany. In Virology, 2014
Here, we identified ELL2 as the sole transcription elongation factor to be specifically upregulated in HTLV-1-/Tax-transformed T-cells.
Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Peterlin et al., San Francisco, United States. In J Biol Chem, 2014
The superelongation complex subunits AF4/FMR2 family member 4 (AFF4) and elongation factor RNA polymerase II 2 (ELL2) were recruited to this proximal promoter after P-TEFb release and were required for its transcriptional effects.
Plasma cell formation, secretion, and persistence: the short and the long of it.
Milcarek et al., Pittsburgh, United States. In Crit Rev Immunol, 2013
Transcription elongation factor ELL2 plays an important role in the induction of Ig secretory mRNA production, the unfolded protein response, and gene expression during hypoxia.
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
Alber et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2013
The HIV-1 Tat protein stimulates viral gene expression by recruiting human transcription elongation complexes containing P-TEFb, AFF4, ELL2, and ENL or AF9 to the viral promoter, but the molecular organization of these complexes remains unknown.
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
Peterlin et al., San Francisco, United States. In J Biol Chem, 2012
Importantly, the knockdown of ELL2, a subunit of the SEC, blocked the ability of JQ1 to increase HIV transcription.
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
Morris et al., Chapel Hill, United States. In Am J Hum Genet, 2012
Through transethnic meta-analysis of European-ancestry and Japanese genome-wide association studies, we identified six loci at genome-wide significance (p < 5 × 10(-8)) for serum albumin (HPN-SCN1B, GCKR-FNDC4, SERPINF2-WDR81, TNFRSF11A-ZCCHC2, FRMD5-WDR76, and RPS11-FCGRT, in up to 53,190 European-ancestry and 9,380 Japanese individuals) and three loci for total protein (TNFRS13B, 6q21.3, and ELL2, in up to 25,539 European-ancestry and 10,168 Japanese individuals).
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Rao et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Through a combination of transcriptional profiling and screening using a lentiviral short-hairpin RNA interference library, we show that both the splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secreted versus membrane-encoding Ighg2b transcripts in MPC11 plasmacytoma cell lines.
The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.
Zhou et al., Xiamen, China. In Mol Cell, 2012
Prostratin and HMBA, two well-studied activators of HIV transcription and latency, enhance ELL2 accumulation and SECs formation largely through decreasing Siah1 expression and ELL2 polyubiquitination.
Selection signature analysis implicates the PC1/PCSK1 region for chicken abdominal fat content.
Li et al., Harbin, China. In Plos One, 2011
This region had 26 SNP markers and seven genes, Mar-03, SLC12A2, FBN2, ERAP1, CAST, PC1/PCSK1 and ELL2, where PC1/PCSK1 are the chicken/human names for the same gene.
Transcriptional and epigenetic regulation of B cell development.
Milcarek et al., Pittsburgh, United States. In Immunol Res, 2011
In this review, we focus on two factors, E47 and ELL2, which play important roles in the regulation of B cell development in the bone marrow and differentiation of mature B cells into plasma cells in the periphery, respectively.
Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
Milcarek et al., Pittsburgh, United States. In Nat Immunol, 2009
ELL2 enhanced both polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex (Igh) and reporter constructs
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