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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)

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Top mentioned proteins: CAN, RBP, miR, tristetraprolin, SET
Papers on ELAVL1
Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer.
Krech et al., Hamburg, Germany. In Prostate, Feb 2016
BACKGROUND: ELAVL1 is an RNA binding protein involved in translation control, which might have a regulatory role in prostate cancer progress.
Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.
Rogers et al., Newark, United States. In J Cell Biochem, Feb 2016
The activating protein HuR (Hu antigen R, ELAVL1, HGNC:3312) directly binds this ARE and can activate gene expression.
Orthogonal matrix factorization enables integrative analysis of multiple RNA binding proteins.
Curk et al., Ljubljana, Slovenia. In Bioinformatics, Feb 2016
We have integrated the largest data compendium to date, which includes 31 CLIP experiments on 19 RBPs involved in splicing (such as hnRNPs, U2AF2, ELAVL1, TDP-43, and FUS) and processing of 3'UTR (Ago, IGF2BP).
Identification of novel proteins binding the AU-rich element of α-prothymosin mRNA through the selection of open reading frames (RIDome).
Cotella et al., Novara, Italy. In Rna Biol, Jan 2016
The method was validated using an RNA bait corresponding to the AU-rich element of α-prothymosin, an RNA motif that promotes mRNA stability and translation through its interaction with the RNA-binding protein ELAVL1.
Global translation variations in host cells upon attack of lytic and sublytic Staphylococcus aureus α-haemolysin.
Viero et al., Trento, Italy. In Biochem J, Dec 2015
By comparing variations occurring in the cellular transcriptome and translatome, we give evidence that global gene expression is primarily rewired at the translational level, with the contribution of the RBP ELAVL1 (HuR) in the sublytic response.
Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells.
Brody et al., Philadelphia, United States. In Oncotarget, Oct 2015
We have previously shown that the mRNA-binding protein HuR (ELAVL1) is elevated in human pancreatic ductal adenocarcinoma (PDA) specimens compared to normal pancreatic tissues, and its cytoplasmic localization is associated with increased tumor stage.
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization.
Mayr et al., New York City, United States. In Nature, Jul 2015
In our model of 3' UTR-dependent protein localization, the long 3' UTR of CD47 acts as a scaffold to recruit a protein complex containing the RNA-binding protein HuR (also known as ELAVL1) and SET to the site of translation.
Genome-wide analysis of alternative transcripts in human breast cancer.
Cai et al., Coral Gables, United States. In Breast Cancer Res Treat, Jun 2015
We uncovered nine splicing factors (FOX2, MBNL1, QKI, PTBP1, ELAVL1, HNRNPC, KHDRBS1, SFRS2, and TIAR) that were involved in aberrant splicing in breast cancer.
HuR keeps interferon-β mRNA stable.
Takeuchi, Kyoto, Japan. In Eur J Immunol, May 2015
2015 45:1500-1511] show that a human RNA-binding protein, embryonic lethal, abnormal vision, drosophila-like 1 (ELAVL1)/Hu antigen R (HuR), strongly associates with IFN-β mRNA via AU-rich sequences present in its 3' untranslated region in various human cell lines.
The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response.
Superti-Furga et al., Vienna, Austria. In Eur J Immunol, May 2015
Here, we applied an affinity proteomic approach and identified lethal, abnormal vision, drosophila-like 1 (ELAVL1)/Hu antigen R (HuR) as the predominant RBP of the IFN-β mRNA ARE.
Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways.
Ibrahim et al., Khartoum, Sudan. In Front Genet, 2014
ELAVL1/HuR showed remarkable centrality, interacting specially with genes harboring non-synonymous SNVs thus reinforcing the proposition of targeted mutagenesis in cancer pathways.
Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells.
Atasoy et al., Saint Louis, United States. In Plos One, 2014
The RBP HuR (ELAVL1) and family members are major stabilizers of mRNA.
A preliminary quantitative proteomic analysis of glioblastoma pseudoprogression.
Zhang et al., Beijing, China. In Proteome Sci, 2014
Moreover, six of the proteins (HNRNPK, ELAVL1, CDH2, FBLN1, CALU and FGB) involved in the two networks were validated (n = 18) in the same six samples and in twelve additional samples using immunohistochemistry methods and the western blot analysis.
Specificity factors in cytoplasmic polyadenylation.
de Moor et al., Denver, United States. In Wiley Interdiscip Rev Rna, 2013
In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1).
Bovine oocytes and early embryos express Staufen and ELAVL RNA-binding proteins.
Watson et al., London, Canada. In Zygote, 2008
STAU1 & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 mRNAs were detectable from the GV to the morula stage; ELAVL2 protein was in all stages
Anp32e (Cpd1) and related protein phosphatase 2 inhibitors.
Santa-Coloma, Buenos Aires, Argentina. In Cerebellum, 2002
In HeLa cells, ANP32A, SET (isoforms A and B) and ANP32B (APRIL), form a multi-subunit heterocomplex with ELAVL1 (NM_001419, formerly HuR), a protein that stabilizes short-lived mRNAs containing AU-rich elements (AREs).
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