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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


elastin, tropoelastin
This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, V1a
Papers on elastin
Toughening of Thermoresponsive Arrested Networks of Elastin-Like Polypeptides To Engineer Cytocompatible Tissue Scaffolds.
Olsen et al., Cambridge, United States. In Biomacromolecules, Feb 2016
UNASSIGNED: Formulation of tissue engineering or regenerative scaffolds from simple bioactive polymers with tunable structure and mechanics is crucial for the regeneration of complex tissues, and hydrogels from recombinant proteins, such as elastin-like polypeptides (ELPs), are promising platforms to support these applications.
Evaluation of a 1540-nm and a 1410-nm Nonablative Fractionated Laser for the Treatment of Striae.
Saedi et al., Philadelphia, United States. In Dermatol Surg, Feb 2016
Skin biopsies after treatment showed an increase in epidermal thickness, dermal thickness, and collagen and elastin density when compared with baseline.
Effects of the three-dimensional residual stresses on the mechanical properties of arterial walls.
Ren et al., Shanghai, China. In J Theor Biol, Feb 2016
Moreover, different constitutive models are proposed to quantify the nonlinear mechanics of the three distinct layers and the important constituents, i.e. elastin, collagen fibers and smooth muscle cells (SMCs), are all taken into account.
Elastic proteins and elastomeric protein alloys.
Weiss et al., Sydney, Australia. In Curr Opin Biotechnol, Feb 2016
Tropoelastin is the soluble monomer component of elastin.
Adipose stem cells isolated from excised burned tissue: is there potential for clinical use?
Granick et al., Newark, United States. In Plast Reconstr Surg, Feb 2016
A human study described the use of these cells spread on collagen-elastin scaffolds placed under skin grafts in patients that had excision of their wounds down to the fascia, resulting in ninety percent viability.This emerging therapy is encouraging as these cells may represent a source of autologous multipotent cells that could help burn patients' wound healing without increasing their morbidity by performing additional fat harvesting procedures.
Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants.
Heilshorn et al., Stanford, United States. In Biomaterials, Feb 2016
UNASSIGNED: Here we present the design of an engineered, elastin-like protein (ELP) that is chemically modified to enable stable coatings on the surfaces of titanium-based dental and orthopaedic implants by novel photocrosslinking and solution processing steps.
Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure.
Milewicz et al., Houston, United States. In Can J Cardiol, Jan 2016
Included in this gene list are the genes encoding protein that are structural components of elastin fibres and microfibrils, FBN1, MFAP5, ELN, and FBLN4.
Evolution of the fish heart by sub/neofunctionalization of an elastin gene.
Koshiba-Takeuchi et al., Tokyo, Japan. In Nat Commun, Dec 2015
Here we reveal that the teleost-specific extracellular matrix (ECM) gene, elastin b, was generated by the teleost-specific whole-genome duplication and neofunctionalized to contribute to acquisition of the BA by regulating cell fate determination of cardiac precursor cells into smooth muscle.
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids.
Isaacs et al., New Haven, United States. In Nat Biotechnol, Dec 2015
These variants enabled production of elastin-like-polypeptides with 30 nsAA residues at high yields (∼50 mg/L) and high accuracy of incorporation (>95%).
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system.
Mata et al., Barcelona, Spain. In Nat Chem, Nov 2015
Here we report on a dynamic system that emerges from the conformational modification of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be maintained in, non-equilibrium for substantial periods of time.
The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source.
Morty et al., Bad Nauheim, Germany. In Front Med (lausanne), 2014
Notable among these are perturbations to ECM structures, namely, the organization of the elastin and collagen networks in the developing lung.
Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.
González et al., Málaga, Spain. In Antioxidants (basel), 2014
Further, UV radiation remodels the ECM by increasing matrixmetalloproteinases (MMP) and reducing structural collagen and elastin.
The role of Ras-ERK-IL-1β signaling pathway in upregulation of elastin expression by human coronary artery smooth muscle cells cultured in 3D scaffolds.
Mequanint et al., London, Canada. In Biomaterials, 2012
endogenous IL-1beta play a role in elastin gene upregulation and this upregulation is mediated by the Ras-ERK1/2 pathway in 3D cultures
Poly(A) tail shortening correlates with mRNA repression in tropoelastin regulation.
Knott et al., Hamburg, Germany. In J Dermatol Sci, 2012
Suggest that maintenance of poly(A) tail and deadenylation of tropoelastin mRNA might be general mechanisms involved in the regulation of tropoelastin expression.
Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery.
Wang et al., Pittsburgh, United States. In Nat Med, 2012
Three months after implantation, the neoarteries resembled native arteries in the following aspects: regular, strong and synchronous pulsation; a confluent endothelium and contractile smooth muscle layers; expression of elastin, collagen and glycosaminoglycan; and tough and compliant mechanical properties.
Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa.
Mecham et al., Saint Louis, United States. In J Biol Chem, 2012
the C-terminal region of tropoelastin in has a critical role in elastic fiber assembly and suggest tissue-specific differences in the elastin assembly pat
Elastin degradation is associated with progressive aortic stiffening and all-cause mortality in predialysis chronic kidney disease.
Holt et al., Brighton, United Kingdom. In Hypertension, 2012
In predialysis chronic kidney disease, elastin degradation is an important determinant of arterial stiffness and is associated with all-cause mortality.
Recombinant protein-based polymers for advanced drug delivery.
Ghandehari et al., Salt Lake City, United States. In Chem Soc Rev, 2012
Research into elastin-like, silk-like, and silk-elastinlike protein polymers for example has led to the development of delivery systems based on natural motifs of structural proteins to take advantage of their physicochemical properties.
An artery-specific fluorescent dye for studying neurovascular coupling.
Kara et al., Charleston, United States. In Nat Methods, 2012
We demonstrate that Alexa Fluor 633 hydrazide (Alexa Fluor 633) selectively labels neocortical arteries and arterioles by binding to elastin fibers.
[Elastin and microfibrils in vascular development and ageing: complementary or opposite roles?].
Faury et al., Saint-Jean-de-la-Ruelle, France. In Biol Aujourdhui, 2011
Elastin and fibrillin-1 roles can be complementary in some aspects, while they can be opposed in some other situations.
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