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Eukaryotic translation initiation factor 4E

eIF4E, eIF4F, eukaryotic translation initiation factor 4E
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: mTOR, CAN, 4E-BP1, V1a, Akt
Papers using eIF4E antibodies
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
White Anthony Robert, In PLoS ONE, 2006
... Recombinant eIF4E protein was purchased from Origene (Rockville, MD, USA) ...
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay.
Preiss Thomas, In PLoS ONE, 2003
... The cell line that stably overexpresses eIF4E was generated using the pBabe retroviral system (Clontech).
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.
Song Haiwei, In PLoS ONE, 2002
... Antibodies to eIF4E (Abcam), PABP ...
Neurotrophin-induced transport of a beta-actin mRNP complex increases beta-actin levels and stimulates growth cone motility
Achsel Tilmann et al., In The Journal of Cell Biology, 2000
... Wells, Yale University, New Haven, CT); mouse α-MAP2 (Sigma-Aldrich); α-SMN (Signal Transduction); mouse α-eIF4E (Santa Cruz Biotechnology, Inc.); goat α-orexin (Santa ...
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.
Holm Magnus, In PLoS ONE, 1974
... eIF4E were amplified from cDNA clones (RH61958, LD29474, BO04660, and RE36735 from the DGRC) by PCR, and introduced into pDNR-Dual (Clontech) at the ...
Papers on eIF4E
Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.
Lama et al., United States. In J Biol Chem, Feb 2016
Dual ATP-competitive TORC1/2 inhibitor AZD8055, in contrast to allosteric mTORC1-specific inhibitor rapamycin, strongly inhibited 4EBP1 phosphorylation and collagen I expression in Fib-MCs.
Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice.
Gao et al., In Reprod Fertil Dev, Feb 2016
In in vitro-cultured ovaries, Rheb and GTP (is 100 ng mL-1 Rheb and 500 ng mL-1 GTP for 48 h) significantly increased follicle diameter, the percentage of primary and secondary follicles and the umber of thecal cells, and upregulated expression of mTOR, phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1), eukaryotic initiation factor (eIF) 4F and cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1).
Ubiquilin Mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
Hedstrom et al., United States. In J Biol Chem, Feb 2016
Cbz-B3A inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation.
Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells.
González et al., Madrid, Spain. In Mol Ther Nucleic Acids, Dec 2015
Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression.
Targeting translation: eIF4E as an emerging anticancer drug target.
Cai et al., Wuhu, China. In Expert Rev Mol Med, Dec 2015
The translation initiation factor eIF4E mediates a rate-limiting process that drives selective translation of many oncongenic proteins such as cyclin D1, survivin and VEGF, thereby contributing to tumour growth, metastasis and therapy resistance.
5' UTR m(6)A Promotes Cap-Independent Translation.
Jaffrey et al., New York City, United States. In Cell, Dec 2015
A single 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficient to recruit the 43S complex to initiate translation in the absence of the cap-binding factor eIF4E.
Signalling to eIF4E in cancer.
Sonenberg et al., Montréal, Canada. In Biochem Soc Trans, Nov 2015
The eukaryotic translation initiation factor 4E (eIF4E), as part of the eIF4F complex, interacts first with the mRNA and facilitates the recruitment of the 40S ribosomal subunit.
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
Ivashkiv et al., New York City, United States. In Nat Immunol, Aug 2015
We found that IFN-γ regulated the metabolism and mRNA translation of human macrophages by targeting the kinases mTORC1 and MNK, both of which converge on the selective regulator of translation initiation eIF4E.
Differential Requirements for eIF4E Dose in Normal Development and Cancer.
Ruggero et al., San Francisco, United States. In Cell, Aug 2015
eIF4E, the major cap-binding protein, has long been considered limiting for translating the mammalian genome.
Targeting the translation machinery in cancer.
Topisirovic et al., Montréal, Canada. In Nat Rev Drug Discov, Apr 2015
In this Review, we discuss the role of translation in cancer, with a particular focus on the eIF4F (eukaryotic translation initiation factor 4F) complex, and provide an overview of recent efforts aiming to 'translate' these results to the clinic.
Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection.
Dikstein et al., Israel. In Cell Metab, Apr 2015
Furthermore, eIF4F is released upon 48S formation on TISU.
Efficient preparation and properties of mRNAs containing a fluorescent cap analog: Anthraniloyl-m(7)GpppG.
Goss et al., Melbourne, Australia. In Translation (austin), 2015
The Ant-m(7)G derivative, which has been previously shown to interact with the eukaryotic cap binding protein eIF4E, is shown in this paper to be a substrate for the Vaccinia capping enzyme and the DCP2 decapping enzyme from Arabidopsis.
The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.
Rocchi et al., Marseille, France. In Adv Protein Chem Struct Biol, 2014
Cap-dependent translation starts when eIF4E binds to mRNA cap domain.
Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.
Morley et al., Brighton, United Kingdom. In Translation (austin), 2014
Initiation of translation involves the interaction of several proteins to form the eIF4F complex, the recognition of the mRNA by this complex, and the subsequent recruitment of the 40S ribosomal subunit to the mRNA.
The role of the poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants.
Gallie, Riverside, United States. In Translation (austin), 2014
eIF4F, composed of eIF4E, eIF4A, and eIF4G, binds to the 5'-cap structure of an mRNA and prepares an mRNA for recruitment of a 40 S subunit.
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
Lasko et al., Montréal, Canada. In Development, 2012
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2.
Chang et al., Tainan City, Taiwan. In Febs Lett, 2012
4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication protein A2
The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
Lichtenstein et al., Los Angeles, United States. In J Biol Chem, 2012
PP242 mTOR inhibitor activates ERK in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance
MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Schneider et al., München, Germany. In Cell Cycle, 2012
The transcription of eIF4E regulates BCLXL expression in gastric cancer cells.
Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity.
Boris-Lawrie et al., Columbus, United States. In Plos Pathog, 2011
Maintenance of nuclear cap binding complex association is a novel mechanism used by HIV-1 to bypass downregulation of eIF4E activity and sustain viral protein synthesis.
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