Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell.
Cambridge, United Kingdom. In J Mol Biol, Nov 2015
These include the regulation of translation via upstream open reading frames, the over-reading of stop codons via ribosomal frameshifting, the existence of an antizyme and an antizyme inhibitor, ubiquitin-independent proteasomal degradation, a complex bi-directional membrane transport system and a unique posttranslational modification-hypusination-that is believed to occur on a single protein only (eIF-5A).
The translation factor eIF5A and human cancer.
Newark, United States. In Biochim Biophys Acta, Jul 2015
The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been assigned functions in both initiation and elongation.
The hypusine-containing translation factor eIF5A.
Bethesda, United States. In Crit Rev Biochem Mol Biol, 2014
The eukaryotic translation initiation factor 5A (eIF5A) and its bacterial ortholog elongation factor P (EF-P) were initially characterized based on their ability to stimulate methionyl-puromycin (Met-Pmn) synthesis, a model assay for protein synthesis; however, the function of these factors in cellular protein synthesis has been difficult to resolve.
A tumour suppressor network relying on the polyamine-hypusine axis.
New York City, United States. In Nature, 2012
Among the new tumour suppressors are adenosylmethionine decarboxylase 1 (AMD1) and eukaryotic translation initiation factor 5A (eIF5A), two genes associated with hypusine, a unique amino acid produced as a product of polyamine metabolism through a highly conserved pathway.