GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Early endosome antigen 1
EEA1, early endosome antigen 1
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Top mentioned proteins:
Rab5, V1a, Transferrin, LAMP-1, CAN
Papers using
EEA1
antibodies
A chemical genetic screen for modulators of exocytic transport identifies inhibitors of a transport mechanism linked to GTR2 function
Supplier
In The Journal of Cell Biology, 2009
Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis.
Supplier
In PLoS ONE, 2009
Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway
Supplier
In The Journal of Cell Biology, 2008
WB, 1/1,000), Tau (Millipore; IF, 1/1,000), EEA1 (Applied Biosystems; IF, 1/500), FLAG (Sigma Aldrich), GFP (Roche) and RFP ...
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
Supplier
In PLoS ONE, 2007
... South San Francisco, CA), rabbit polyclonal anti-EEA1 (Enzo Life Sciences, Plymouth Meeting, PA), mouse monoclonal anti-EEA1 (BD Biosciences, Franklin Lakes, NJ), mouse ...
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
more suppliersSupplier
In PLoS Biology, 2006
... obtained from commercial sources: rabbit anti-GRASP-1 (AB96361), mouse anti-β-actin, mouse anti-GluR2 (Chemicon), mouse anti-Rab4, mouse anti-EEA1 (BD Biosciences), mouse anti-FLAG, mouse anti-MAP2, ...
Papers on
EEA1
Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling.
New
Ulsan, South Korea. In Mol Biol Cell, Feb 2016
It colocalized and interacted with EEA1 and Rab5 on endosomes in a phosphatidylinositol 3-kinase-dependent manner.
Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology.
New
Dresden, Germany. In Cancer Res, Feb 2016
We found that NRP2 depletion in human prostate and pancreatic cancer cells resulted in the accumulation of EEA1/Rab5-positive early endosomes concomitant with a decrease in Rab7-positive late endosomes, suggesting a delay in early-to-late endosome maturation.
Quantum dots implementation as a label for analysis of early stages of EGF receptor endocytosis: a comparative study on cultured cells.
New
Saint Petersburg, Russia. In Oncotarget, Jan 2016
Yet, the bEGF-savQD demonstrated similar to native EGF and bEGF-savCy3 co-localization dynamics with tethering protein EEA1 and HRS, the key component of sorting ESCRT0 complex.
Localization of the human neonatal Fc receptor (FcRn) in human nasal epithelium.
New
Vienna, Austria. In Protoplasma, Jan 2016
Co-localization of FcRn α-chain with IgG or with early sorting endosomes (EEA1-positive) but not with late endosomes/lysosomes (LAMP-2-positive) in ciliated cells was observed.
Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase.
New
Lanzhou, China. In Sci Rep, Dec 2015
Moreover, intracellular trafficking of FMDV involves EEA1/Rab5-positive vesicles.
The p97 ATPase associates with EEA1 to regulate the size of early endosomes.
GeneRIF
Bethesda, United States. In Cell Res, 2012
p97 inhibition causes increased EEA1 self-association at the endosome membrane.
Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1.
GeneRIF
Nanjing, China. In Mol Med Report, 2011
The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1.
Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
GeneRIF
Atlanta, United States. In J Biol Chem, 2011
PKC-alpha is a necessary regulator of EEA1-dependent Akt signaling in early endosomes.
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1).
GeneRIF
Worcester, United States. In Proc Natl Acad Sci U S A, 2010
crystal structure of Rab5A in complex with the EEA1 C(2)H(2) zinc finger
[Effectors of GTPase Rab5 in endocytosis and signal transduction].
Review
Warsaw, Poland. In Postepy Biochem, 2008
Small GTPase Rab5 is a multifunctional protein, which regulates early steps of endocytosis, due to its interactions with numerous effectors such as: Rabaptin-5/Rabex-5, EEA1, phosphatidylinositol 3-kinases hVPS34-p150 and p110beta-p85alpha, phosphatidylinositol 4- and 5-phosphatases, Rabenosyn-5/hVPS45, Rabankyrin-5, Huntingtin-HAP40, APPL1 and APPL2.
Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it.
Review
Albuquerque, United States. In Future Microbiol, 2008
PI3P earmarks intracellular organelles for binding and assembly of effector molecules that interact with PI3P or its derivatives, including Class E Vps proteins such as Hrs and ESCRT components, early endosome antigen 1, which are required for sequential protein and membrane sorting within the endosomal and, by extension, phagosomal systems.
Francisella tularensis invasion of lung epithelial cells.
GeneRIF
Chapel Hill, United States. In Infect Immun, 2008
F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively.
The physiology of phosphoinositides.
Review
Akita, Japan. In Biol Pharm Bull, 2007
Protein domains that bind phosphoinositides include the pleckstrin homology (PH) domain, the phox homology (PX) domain and the Fab1p-YOPB-Vps27p-EEA1 (FYVE) domain.
Evolutionarily conserved structural and functional roles of the FYVE domain.
Review
Worcester, United States. In Biochem Soc Symp, 2006
In mammalian cells, these mechanisms are apparent in the existence of proteins that bind PtdIns3P and Rab GTPases, such as EEA1, Rabenosyn-5 and Rabip4'.
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis.
Impact
Boston, United States. In Immunity, 2005
Perforin also triggers the rapid endocytosis of granzymes into large EEA-1-staining vesicles.
A GTPase-activating protein controls Rab5 function in endocytic trafficking.
Impact
Martinsried, Germany. In Nat Cell Biol, 2005
RabGAP-5 overexpression triggers a loss of the Rab5 effector EEA1 from endosomes and blocks endocytic trafficking.
Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells.
Impact
Paris, France. In Nat Cell Biol, 2005
First, we show that L. monocytogenes colocalizes with Met, EEA1, Cbl, clathrin and dynamin during entry.
Molecular mechanisms and drug development in aquaporin water channel diseases: water channel aquaporin-2 of kidney collecting duct cells.
Review
Maebashi, Japan. In J Pharmacol Sci, 2004
The early endosomal marker EEA1 is colocalized with some of AQP2 vesicles.
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
Impact
Toronto, Canada. In Nat Cell Biol, 2003
Here we demonstrate that TGF-beta receptors internalize into both caveolin- and EEA1-positive vesicles and reside in both lipid raft and non-raft membrane domains.
Structural mechanism of endosome docking by the FYVE domain.
More papers using
EEA1
antibodies
Impact
Denver, United States. In Science, 2001
Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles.
Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies
Supplier
In The Journal of Cell Biology, 2006
Functional dissection of Rab GTPases involved in primary cilium formation
Supplier
In The Journal of Cell Biology, 2005
... ), mouse anti-EEA1 (clone 14; Becton Dickinson); mouse anti-human transferrin receptor ...
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils.
Supplier
In PLoS ONE, 2005
... (Ser473) antibody was from Cell Signalling, anti-Akt1/2 and anti-DNA-PKcs antibodies were from Santa Cruz, and anti-EEA1 was from GenScript.
Adaptation of enterocytic Caco-2 cells to glucose modulates triacylglycerol-rich lipoprotein secretion through triacylglycerol targeting into the endoplasmic reticulum lumen.
Supplier
In PLoS ONE, 2005
... rabbit polyclonal anti-P-p38 MAPK (Thr180/Tyr182, Cell Signaling), mouse monoclonal anti-E-cadh (BD transduction laboratories), goat polyclonal anti-EEA1 (Santa Cruz Biotechnology), mouse monoclonal anti-flotillin-1 (BD ...
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Supplier
In The Journal of Cell Biology, 2004
... anti-GFP (Invitrogen), 9E10 mouse anti-myc, rabbit anti–MAP-LC3 (Santa Cruz Biotechnology Inc.), rabbit anti–MAP-LC3 (Sigma-Aldrich), mouse anti-EEA1 (BD Biosciences), rabbit anti-calnexin (Assay Designs), ...
Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping.
Supplier
In PLoS ONE, 2003
... antibody (clone 23A8; Upstate) recognizing non-glucosylated Rac1; antibody against β-Actin (clone AC15) was from Sigma; α-EEA1 was purchased from BD Transduction Laboratories; horseradish-conjugated goat anti-mouse IgG and goat anti-rabbit IgG were from Rockland Immunochemicals and Bafilomycin A1 ...
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation
Supplier
In The Journal of Cell Biology, 2001
... (Sigma-Aldrich), goat polyclonal neutralizing anti–c-Met, monoclonal anti–human c-Met extracellular domain (clone DO24; Millipore), goat polyclonal anti-EEA1 (Santa Cruz Biotechnology, Inc.), and mouse monoclonal ...
Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the “cooperative end structures” model
Supplier
In The Journal of Cell Biology, 2000
... anti-FGFR3, anti-FGFR4, rabbit anti–FRS-2α, mouse anti-NCAM (clone 123C3), anti-Src kinases, anti-GFP, antiubiquitin, and anti-Rab25; goat anti-EEA1 (Santa Cruz Biotechnology, Inc.); mouse anti–PLC-γ, anti-Cbl, ...
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
Supplier
In The Journal of Cell Biology, 2000
... Antibody to EEA-1 was goat polyclonal N-19 (sc-6415; Santa Cruz Biotechnology, Inc.); antibody to caveolin-1 ...
The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment
Supplier
In Cell Death & Disease, 2000
... (MAD; a gift from Professor Viki Allan, Manchester, UK), anti-ERGIC53 (Alexis Biochemicals), anti-calnexin (Stressgen, Exeter, UK), anti-EEA-1 (BD Biosciences), anti-transferrin receptor (Sigma), monoclonal ...
Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
Supplier
In The Journal of Cell Biology, 2000
... The antibody reagents used were as follows: mouse anti-GM130 and EEA1 (Becton Dickinson), sheep anti-TGN46 (Serotec), rabbit ...
Phospholipase D activity is required for actin stress fiber formation in fibroblasts.
Supplier
In PLoS ONE, 2000
... The monoclonal antibodies against β-catenin, E-cadherin, PCNA, and EEA1 were obtained from BD Biosciences (San Jose, CA) ...
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
Supplier
In The Journal of Cell Biology, 1999
... Technology), anti-Smad4 (Santa Cruz Biotechnology, Inc; H552), anti-Smad2 (Cell Signaling Technology), anti-M6PR (Affinity BioReagents, Inc.), anti-EEA1 (BD Biosciences), anti-TGN38 (BD Biosciences), anti–mouse ...
Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-Golgi network
Supplier
In The Journal of Cell Biology, 1999
... Mouse monoclonal anti-Tyrp1 (ab3312), HMB-45 to Pmel17 (ab787), anti-EEA1 (ab15846), anti-CD9 (ab19761), and rabbit polyclonal anti–β-tubulin (ab6046) were obtained from Abcam.
Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Supplier
In PLoS ONE, 1999
... Louis, Missouri), anti-EEA1 goat polyclonal (Santa Cruz Biotechnology, Santa Cruz, CA), anti-ITSN1 ...
CLIPR-59, a new trans-Golgi/TGN cytoplasmic linker protein belonging to the CLIP-170 family
Supplier
In The Journal of Cell Biology, 1999
... Other polyclonal antibodies used in this study were: anti-GFP (Molecular Probes), anti-EEA1 (Santa Cruz Biotechnology, Inc.), anti-galactosyltransferase (provided by ...
Inhibition and Redistribution of NHE3, the Apical Na+/H+ Exchanger, by Clostridium difficile Toxin B
Supplier
In The Journal of General Physiology, 1994
... Goat anti-EEA1 antibody (N19) was from Santa Cruz Biotechnology, Inc ...
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
Supplier
In The Journal of Cell Biology, 1992
... Goat anti-EEA1 antibody (N19) was from Santa Cruz Biotechnology.
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Supplier
In PLoS ONE, 1969
