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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Alpha hemoglobin stabilizing protein

Top mentioned proteins: CAN, HAD, ACID, V1a, endothelin-1
Papers on EDRF
Endothelial Dysfunction and Vascular Disease - A Thirthieth Anniversary Update.
Tang et al., Hong Kong, Hong Kong. In Acta Physiol (oxf), Jan 2016
The best characterized endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) which activates soluble guanylyl cyclase in the vascular smooth muscle cells, with the production of cyclic huanosine monophosphate (cGMP) initiating relaxation.
Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation.
Clough et al., London, United Kingdom. In J Hypertens, Jan 2016
OBJECTIVES: The endothelium maintains vascular homeostasis through the release of endothelium-derived relaxing factors (EDRF) and endothelium-derived hyperpolarization (EDH).
Study of alpha hemoglobin stabilizing protein expression in patients with β thalassemia and sickle cell anemia and its impact on clinical severity.
Ragab et al., Cairo, Egypt. In Blood Cells Mol Dis, Dec 2015
UNLABELLED: The α hemoglobin stabilizing protein (AHSP) binds α-Hb and prevents its precipitation limiting free α-Hb toxicities.
Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.
Kishor et al., Gwalior, India. In Blood Cells Mol Dis, Aug 2015
Alpha hemoglobin stabilizing protein (AHSP), the erythroid specific alpha globin chaperone, stabilizes free alpha chains, and prevents the formation of reactive oxygen radicals.
Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes.
Kobayashi et al., Tokyo, Japan. In Br J Pharmacol, Aug 2015
However, in disease states, such as diabetes and arterial hypertension, there is an imbalance between EDRF and EDCF, with a reduction of EDRF signalling and an increase of EDCF signalling.
Hb Cervantes, Hb Marañón, Hb La Mancha and Hb Goya: Description of 4 new haemoglobinopathies.
Ropero et al., Madrid, Spain. In Clin Biochem, Jul 2015
RESULTS: The hyper-instability of Hb Cervantes is probably due to its lower affinity for the alpha chain haemoglobin-stabilizing protein (AHSP).
[Role of alpha-hemoglobin molecular chaperone in the hemoglobin formation and clinical expression of some hemoglobinopathies].
Baudin-Creuza et al., Créteil, France. In Transfus Clin Biol, Mar 2015
Alpha-hemoglobin stabilizing protein (AHSP), described as a chaperone of alpha-hemoglobin (α-Hb), is synthesized at a high concentration in the erythroid precursors.
Nitric oxide synthases, S-nitrosylation and cardiovascular health: from molecular mechanisms to therapeutic opportunities (review).
Gonzalez et al., Talca, Chile. In Mol Med Report, Mar 2015
The understanding of nitric oxide (NO) signaling has grown substantially since the identification of endothelial derived relaxing factor (EDRF).
Implications of fundamental signalling alterations in diabetes mellitus-associated cardiovascular disease .
Balakumar, In Indian J Biochem Biophys, 2014
In fact, DM is associated with multi-factorial cardiovascular signalling alterations via significant modulation of expression pattern, activation or release of PI3K, PKB, eNOS, EDRF, NADPH oxidase, EDHF, CGRP, adenosine, iNOS, ROCK, PKC-β2, CaMKII, microRNA (miR)-126 and miR-130a, which could result in inadequate maintenance of cardiovascular physiology and subsequent development of cardiovascular pathology.
sGC-cGMP signaling: target for anticancer therapy.
Murad et al., Washington, D.C., United States. In Adv Exp Med Biol, 2013
Murad's lab established link between the endothelium derived relaxation factor (EDRF) and elevated cGMP concentration in the vascular system.
Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Weiss et al., Philadelphia, United States. In J Biol Chem, 2012
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.
Olson et al., Houston, United States. In J Biol Chem, 2012
AHSP acts as a molecular chaperone by rapidly binding and stabilizing met-alpha hemichrome folding intermediates
α-Haemoglobin stabilising protein expression is influenced by mean cell haemoglobin and HbF levels in HbE/β-thalassaemia individuals.
Lai et al., Malaysia. In Blood Cells Mol Dis, 2012
AHSP could be a secondary compensatory mechanism in red blood cells to counterbalance the excess of alpha-globin chains in HbE/beta-thalassaemia individuals.
NF-E2: a novel regulator of alpha-hemoglobin stabilizing protein gene expression.
Chih-chuan et al., Beijing, China. In Chin Med Sci J, 2010
NF-E2 may play an important role in AHSP gene regulation, providing new insights into the molecular mechanisms underlying the erythroid-specific expression of AHSP as well as new possibilities for beta-thalassemia treatment
Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.
Persons et al., In Am J Hematol, 2010
Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice.
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.
Shi et al., Princeton, United States. In Nature, 2005
The alpha-haemoglobin-stabilizing protein (AHSP) binds alpha-haemoglobin (alphaHb), inhibits the ability of alphaHb to generate reactive oxygen species and prevents its precipitation on exposure to oxidant stress.
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.
Shi et al., Princeton, United States. In Cell, 2004
In erythrocytes, the alpha-hemoglobin stabilizing protein (AHSP) binds alphaHb and inhibits its precipitation.
An abundant erythroid protein that stabilizes free alpha-haemoglobin.
Weiss et al., Philadelphia, United States. In Nature, 2002
An abundant erythroid protein that stabilizes free alpha-haemoglobin.
The 1996 Albert Lasker Medical Research Awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide.
Furchgott, New York City, United States. In Jama, 1996
The discovery of endothelium-derived relaxing factor (EDRF) and its importance in the identification of nitric oxide (NO) originated with studies using rabbit aorta to examine drug-receptor interactions in vascular smooth muscle.
Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock.
Lefer et al., Philadelphia, United States. In Annu Rev Pharmacol Toxicol, 1992
These substances can be classified into three broad categories: (a) substances replacing endogenous cytoprotective agents of endothelial origin including prostacyclin (PGI2), endothelium-derived relaxing factor (EDRF), and adenosine: the endothelium protecting agents include these substances as well as stable analogs of PGI2, and nitric oxide donors; (b) substances that inhibit pro-inflammatory mediators of endothelial origin: the pro-inflammatory agents are primarily platelet activating factor (PAF) and oxygen-derived free radicals (e.g.
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