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Enoyl CoA hydratase 1, peroxisomal

ECH1, Delta3,5-Delta2,4-dienoyl-CoA isomerase, Dienoyl-CoA-Isomerase
This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibrillin-1, ACID, ToF, Dlx5, CAN
Papers on ECH1
Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D.
Yang et al., Aomen, Macao. In Chin J Nat Med, Sep 2015
Sixteen proteins were identified to be up-regulated in PD-treated HepG2 cells, including ATP5H, OXCT1, KRT9, CCDC40, ERP29, RCN1, ZNF175, HNRNPH1, HSP27, PA2G4, PHB, BANF1, TPM3, ECH1, LGALS1, and MYL6.
Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.
Dai et al., Beijing, China. In Arch Toxicol, Aug 2015
Among them, six significantly changed proteins (CTE1, MTE1, HADHA, ECH1, ALDH2 and CPS1) were found to be regulated by peroxisome proliferator-activated receptor alpha (PPARα).
Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel.
Johnson et al., Aurora, United States. In Plos One, 2014
Hepatic fat accumulation occurred during the summer with relatively increased enzymes associated with fat synthesis (FAS, ACL and ACC) and decreased enoyl CoA hydratase (ECH1) and carnitine palmitoyltransferase 1A (CPT1A), rate limiting enzymes of fat oxidation.
NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism.
Eling et al., United States. In Int J Obes (lond), 2014
hNAG-1 mice and obese mice treated with hNAG-1-expressing xenografts show increased thermogenic gene expression (UCP1, PGC1α, ECH1, Cox8b, Dio2, Cyc1, PGC1β, PPARα, Elvol3) in brown adipose tissue (BAT) and increased expression of lipolytic genes (Adrb3, ATGL, HSL) in both white adipose tissue (WAT) and BAT, consistent with higher energy metabolism.
Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues.
Unno et al., Sendai, Japan. In Int J Cancer, 2013
Among these proteins, we found that three novel proteins ECH1, OLFM4 and STML2 were overexpressed in poor group than in better group, and that one known protein GTR1 was expressed reciprocally.
Postprandial changes in the proteome are modulated by dietary fat in patients with metabolic syndrome.
Lopez-Miranda et al., Córdoba, Spain. In J Nutr Biochem, 2013
HPUFA meal supplementation with n-3 PUFA produced peroxisomal beta-oxidation inhibition by down-regulation of ECH1, a process related to insulin signaling improvement.
Mitochondrial proteomics of nasopharyngeal carcinoma metastasis.
Chen et al., Changsha, China. In Bmc Med Genomics, 2011
Ten mitochondrial DEPs including PRDX3, PRDX6, SOD2, ECH1, SERPINB5, COX5A, PDIA5, EIF5A, IDH3B, and PSMC4 were rationalized in the tumor-stroma co-evolution model that mitochondrial oxidative stress directly contributes to tumor metastasis.
[Comparison of proteomics between acute myeloid leukemia and acute lymphoid leukemia].
Lin et al., Foshan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
In AML, seven proteins were highly expressed such as MPO, PRDX3, CALR and ECH1 and so on, and eight proteins were highly expressed in ALL, including ARHGDIB, PFN1 and ACTG1 and so on.
[Expression of enoyl CoA hydratase 1 reduces cell proliferation and migration in mouse hepatocarcinoma cells].
Jin et al., Dalian, China. In Zhonghua Bing Li Xue Za Zhi, 2011
Down-regulation of ECH1 could inhibit the cell proliferation and migration of Hca-F hepatocarcinoma cells.
Enoyl coenzyme A hydratase 1 is an important factor in the lymphatic metastasis of tumors.
Tang et al., Dalian, China. In Biomed Pharmacother, 2011
The downregulation of Ech1 inhibited proliferation of the Hca-F cells, increased the ratio of Hca-F cells in S phase to G(1) phase and decreased the adhesion and migration capacities of Hca-F cells.
Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells.
Kim et al., Seoul, South Korea. In Exp Gerontol, 2011
In addition, we determined five differentially expressed spots in the 2-DE map, which were identified as Annexin A2 (ANXA2), myosin light chain 2 (MLC2), peroxisomal enoyl-CoA hydratase 1 (ECH1), prosomal protein P30-33K (PSMA1) and mutant β-actin by ESI-Q-TOF MS/MS.
Euchresta horsfieldii Benn. activates peroxisome proliferator-activated receptor α and regulates expression of genes involved in fatty acid metabolism in human HepG2 cells.
Hwang et al., Seoul, South Korea. In J Ethnopharmacol, 2011
In human HepG2 hepatocytes, EHX increased mRNA levels of the following genes involved in fatty acid oxidation: carnitine palmitoyltransferase 1, liver form (CPT1L), acyl-CoA synthetase (ACS), medium-chain acyl-CoA dehydrogenase (MCAD), 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), acyl-CoA 1 (ACO1), acyl-CoA 2 (ACO2), and enoyl-CoA hydratase 1 (ECH1).
Proteome profile in Myotonic Dystrophy type 2 myotubes reveals dysfunction in protein processing and mitochondrial pathways.
Zippel et al., Milano, Italy. In Neurobiol Dis, 2010
Our results indicate that the proteins, altered in DM2 cultures, belong to two major functional categories: i) mitochondrial components, with a reduction of EFTu, HSP60, GRP75 and Dienoyl-CoA-Isomerase, an enzyme involved in fatty acids degradation; ii) the ubiquitin proteasome system with increase of the 26S proteasome regulatory subunit 13 and a reduction of Proteasome subunit Alfa6 and of Rad23B homolog.
Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation.
Patricelli et al., Los Angeles, United States. In J Toxicol Sci, 2010
Fenofibrate increased the expression of ACAA2, DECR1, and ECH1 consistent with activation of PPARalpha.
[Preparation and identification of monoclonal antibody against enoyl-CoA hydratase 1].
Sun et al., Beijing, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2009
OBJECTIVE: To prepare monoclonal antibodies (mAbs) against enoyl-CoA hydratase 1 (ECH1).
Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated muscle tissue.
Shishkin et al., Moscow, Russia. In Biochemistry (mosc), 2006
Polymorphism of delta3,5-delta2,4-dienoyl-coenzyme A isomerase (the ECH1 gene product protein) in human striated muscle tissue
[2,4-Dienoyl-CoA reductases: from discovery toward pathophysiological significance].
Morishima et al., Takedamachi, Japan. In Nihon Rinsho, 2004
These taken together with the discovery of a novel delta3,5-delta2,4-dienoyl CoA isomerase and the absence of 3-hydroxyacyl-CoA epimerase have caused the classical metabolic pathway for beta-oxidation of unsaturated fatty acids, depicted by Stoffel in 1965, to be rewritten, and 2,4-dienoyl-CoA reductases are now known to be essential to beta-oxidation of unsaturated fatty acids.
Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.
Reddy et al., United States. In J Biol Chem, 2003
disruption of peroxisomal fatty acid beta-oxidation at the level of enoyl-CoA hydratase/L-3-hydroxyacyl-CoA dehydrogenase (L-PBE) in mice leads to the induction of many of the PPARalpha target genes independently of peroxisome proliferation in hepatocytes
Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase.
Valle et al., Baltimore, United States. In Genomics, 1995
Possible roles for the ECH1 protein product in peroxisomal beta-oxidation are discussed.
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