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Proliferation-associated 2G4, 38kDa

Ebp1, PA2G4, ErbB3 binding protein Ebp1
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: erbB-3, V1a, CAN, PCNA, HAD
Papers on Ebp1
Exendin-4 attenuates cardiac hypertrophy via AMPK/mTOR signaling pathway activation.
He et al., Guangzhou, China. In Biochem Biophys Res Commun, Jan 2016
Furthermore, our data demonstrate that the AMPK inhibitor compound C inhibited the anti-hypertrophic effect of exendin-4, which is associated with the mTOR/p70S6K/4-EBP1 signaling pathway.
High expression of ErbB3 binding protein 1 (EBP1) predicts poor prognosis of pancreatic ductal adenocarcinoma (PDAC).
Wan et al., Nantong, China. In Tumour Biol, Dec 2015
Recent studies have identified that ErbB3 binding protein 1 (EBP1) is broadly expressed in various cancer tissues and critically involved in plenty of biological processes in this regard.
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
Zhang et al., Linyi, China. In Tumour Biol, Nov 2015
Ebp1, a protein identified by its interactions with the ErbB3 receptor, has been characterized as a negative regulator of cancers.
ErbB3 binding protein 1 (EBP1) participates in the regulation of intestinal inflammation via mediating Akt signaling pathway.
Zhang et al., Nantong, China. In Mol Immunol, Oct 2015
ErbB3 binding protein-1 (EBP1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, differentiation and apoptosis.
Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D.
Yang et al., Aomen, Macao. In Chin J Nat Med, Sep 2015
Sixteen proteins were identified to be up-regulated in PD-treated HepG2 cells, including ATP5H, OXCT1, KRT9, CCDC40, ERP29, RCN1, ZNF175, HNRNPH1, HSP27, PA2G4, PHB, BANF1, TPM3, ECH1, LGALS1, and MYL6.
A novel Anxa2-interacting protein Ebp1 inhibits cancer proliferation and invasion by suppressing Anxa2 protein level.
Niu et al., Tianjin, China. In Mol Cell Endocrinol, Sep 2015
Using Gene Ontology, pathway annotation, and protein-protein interaction analyses, we constructed a connected network for Anxa2 interacting proteins, and Ebp1 may function as a "hub" in the Anxa2 interaction network.
EBP1 protein modulates the expression of human MHC class II molecules in non-hematopoietic cancer cells.
Del Pozzo et al., Napoli, Italy. In Int J Oncol, Aug 2015
We studied EBP1, an ErbB3 binding protein, and the effects of p48 and p42 isoforms on the MHC II expression in U87 glioblastoma, M14 melanoma and MCF7 mammary carcinoma cell lines.
The polymorphism of rs6505162 in the MIR423 coding region and recurrent pregnancy loss.
Xia et al., Beijing, China. In Reproduction, Jul 2015
Further investigations showed that MIR423 could inversely regulate the expression of proliferation-associated 2 group 4 (PA2G4) by binding the 3'-UTR of PA2G4.
The ErbB3-binding protein EBP1 modulates lapatinib sensitivity in prostate cancer cells.
Hamburger et al., Baltimore, United States. In Mol Cell Biochem, Jul 2015
The ErbB3-binding protein EBP1 affects both ErbB2 and androgen receptor signaling, two components of the response to ErbB-targeted therapies.
Use of recombinant oestrogen binding protein for the electrochemical detection of oestrogen.
Baronian et al., Christchurch, New Zealand. In Biosens Bioelectron, May 2015
We have previously reported the development of an electrochemical method to quantitatively detect vertebrate oestrogens using an oestrogen binding protein (EBP1) present in wild type Saccharomyces cerevisiae and Candida albicans cells.
Upregulated expression of ebp1 contributes to schwann cell differentiation and migration after sciatic nerve crush.
Wang et al., Nantong, China. In J Mol Neurosci, 2014
Ebp1, an ErbB3-binding protein, is the human homologue of the cell cycle-regulated mouse protein p38-2G4.
The downregulation of ErbB3 binding protein 1 (EBP1) is associated with poor prognosis and enhanced cell proliferation in hepatocellular carcinoma.
Wan et al., Nantong, China. In Mol Cell Biochem, 2014
ErbB3 binding protein 1 (EBP1) has been recently reported to function as a tumor suppressor in the progression of multiple cancers, including breast cancer, prostate cancer, salivary adenoid cystic carcinoma (ACC), and oral squamous cell carcinoma (OSCC).
Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization.
Ahn et al., Suwŏn, South Korea. In Exp Cell Res, 2012
It was shown that high level of Ebp1 expression led to enhancee HDM2 phosphorylation by Akt and inhibited the self-ubiquitination of HDM2 by up-regulation of Akt activity.
EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells.
Hamburger et al., Baltimore, United States. In Anticancer Res, 2011
These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in castration-resistant prostate cancer.
Influenza virus infection induces cellular Ebp1 gene expression.
Honda et al., Koganei, Japan. In Genes Cells, 2011
the Ebp1 promoter localizes between -664 nt and the initiation site of the Ebp1 gene, +317-nt long sequence in the noncoding region is required for regulation of Ebp1 gene expression.
Cell-cycle control as a target for calcium, hormonal and developmental signals: the role of phosphorylation in the retinoblastoma-centred pathway.
Horváth et al., Szeged, Hungary. In Ann Bot, 2011
Over-expression of the EBP1 gene (plant homologue of the ErbB-3 epidermal growth factor receptor-binding protein) increased biomass by auxin-dependent activation of both D- and B-type cyclins.
p48 Ebp1 acts as a downstream mediator of Trk signaling in neurons, contributing neuronal differentiation.
Ahn et al., Suwŏn, South Korea. In Neurochem Int, 2011
Ebp1 contributes to neuronal cell differentiation and growth factor specificity through the activation of protein kinase Cdelta acting as a crucial downstream effector of neurotrophin signaling.
Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors.
Ahn et al., Suwŏn, South Korea. In Cancer Res, 2011
Findings suggest that eBP1 p48 functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to p53 downregulation.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Neuregulin 1 activates ERBB receptors releasing a factor, EBP1, known to inhibit the influenza virus transcriptase.
The ERBB3 receptor in cancer and cancer gene therapy.
Anderson et al., Frederick, United States. In Cancer Gene Ther, 2008
Downstream it interacts prominently with the phosphoinositol 3-kinase/AKT survival/mitogenic pathway, but also with GRB, SHC, SRC, ABL, rasGAP, SYK and the transcription regulator EBP1.
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