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Retinitis pigmentosa GTPase regulator

This gene encodes a protein with a series of six RCC1-like domains (RLDs), characteristic of the highly conserved guanine nucleotide exchange factors. The encoded protein is found in the Golgi body and interacts with RPGRIP1. This protein localizes to the outer segment of rod photoreceptors and is essential for their viability. Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP). Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length natures of only some have been determined. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, Actin, ACID
Papers using EB1 antibodies
incorporation into growing microtubules modulates polymer stability.
Soldati Thierry, In PLoS ONE, 2009
... Anti-total EB1 (mouse monoclonal IgG antibody against the C-terminal part of EB1, amino-acids 107–268) was from BD Biosciences.
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... Biosciences), mouse anti-cyclin B1 (Millipore), rabbit anti-CenpE (Bethyl Laboratories, Inc.), rabbit anti-DYNLL1 (Epitomics, Inc.), mouse anti-EB1 (Cell Signaling Technology), rabbit anti-FLAG (Sigma-Aldrich), ...
Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient
Scholey Jonathan M. et al., In The Journal of Cell Biology, 2005
... The EB1-GFP transgenic fly was a gift from ...
Feature point tracking and trajectory analysis for video imaging in cell biology
Rolls Melissa M et al., In Neural Development, 2004
... tau-GFP and UAS-EB1-GFP lines were described previously [10,43].We generated the UAS-γ-tubulin-GFP transgenic fly line as follows ...
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC
Akhmanova Anna et al., In The Journal of Cell Biology, 2003
... HA-tagged EB1 deletion mutants were generated by a PCR-based strategy and subcloned into the pEGFP-N1 vector (Clontech Laboratories, Inc.), which was ...
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Papers on EB1
Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions.
Rolls et al., Paraguay. In Cytoskeleton (hoboken), Feb 2016
UNASSIGNED: In Drosophila neurons, kinesin-2, EB1 and Apc are required to maintain minus-end-out dendrite microtubule polarity, and we previously proposed they steer microtubules at branch points.
The acetylenic tricyclic bis(cyano enone), TBE-31, targets microtubule dynamics and cell polarity in migrating cells.
Di Guglielmo et al., London, Canada. In Biochim Biophys Acta, Feb 2016
Here, we show that the tricyclic compound TBE-31 directly binds to tubulin and interferes with microtubule dynamics, as assessed by end binding 1 (EB1) live cell imaging.
Exome Sequencing Reveals AGBL5 as Novel Candidate Gene and Additional Variants for Retinitis Pigmentosa in Five Turkish Families.
Epplen et al., Bochum, Germany. In Invest Ophthalmol Vis Sci, Jan 2016
RESULTS: Among all candidate genes for retinal degeneration we found two previously known sequence variations: a 4 bp deletion in the RPGR gene (c.1662_1665delAGAA;
H2-EB1 Molecule Alleviates Allergic Rhinitis Symptoms of H2-Eb1 Knockout Mice.
Zhang et al., Ürümqi, China. In Iran J Immunol, Dec 2015
BACKGROUND: H2-EB1 molecule which is the homolog of Human HLA-DRB1 is proposed to be associated with allergic rhinitis (AR).
Control of microtubule organization and dynamics: two ends in the limelight.
Steinmetz et al., Utrecht, Netherlands. In Nat Rev Mol Cell Biol, Dec 2015
Significant advances have been made in our understanding of microtubule plus-end-tracking proteins (+TIPs) such as end-binding protein 1 (EB1), XMAP215, selected kinesins and dynein.
Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers.
Kashyap, San Diego, United States. In Tumour Biol, Nov 2015
The insulin family of proteins include insulin-like growth factor binding proteins (IGFBPs) that are classified into two groups based on their differential affinities to IGFs: IGF high-affinity binding proteins (IGFBP1-6) and IGF low-affinity IGFBP-related proteins (IGFBP-rP1-10).
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment.
Howard et al., New Haven, United States. In Trends Cell Biol, Nov 2015
However, many other MAPs, notably Kinesin-4 and combinations of EB1 with XMAP215, contradict this general rule.
RPGR: Its role in photoreceptor physiology, human disease, and future therapies.
Wright et al., Edinburgh, United Kingdom. In Exp Eye Res, Sep 2015
Mutations affecting the Retinitis Pigmentosa GTPase Regulator (RPGR) protein is one such cause, affecting 10-20% of all people with RP and the majority of those with X-linked RP.
Microtubule-associated proteins control the kinetics of microtubule nucleation.
Brouhard et al., Montréal, Canada. In Nat Cell Biol, Jul 2015
Catastrophe factors (MCAK and EB1) inhibited nucleation, whereas a polymerase (XMAP215) and an anti-catastrophe factor (TPX2) promoted nucleation.
Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa.
Ffrench-Constant et al., Edinburgh, United Kingdom. In Lancet, Mar 2015
Mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene cause 20% of all cases.
Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection.
Bragonzi et al., Milano, Italy. In Bmc Genomics, 2014
Comparisons with strains RP1, isolated at the onset of the colonization, and clonal RP45, isolated 7 years before RP73 were carried out to better characterize genomic evolution of P. aeruginosa in the context of CF pathogenicity.
The Role of RPGR and Its Interacting Proteins in Ciliopathies.
Shu et al., Greenock, United Kingdom. In J Ophthalmol, 2014
The retinitis pigmentosa GTPase regulator (RPGR) gene is mutated in up to 20% of all RP patients.
Developmental Nuclear Localization and Quantification of GFP-Tagged EB1c in Arabidopsis Root Using Light-Sheet Microscopy.
Šamaj et al., Olomouc, Czech Republic. In Front Plant Sci, 2014
Unlike the other two members of the EB1 family, plant-specific EB1c shows prominent nuclear localization in non-dividing cells in all developmental zones of the root apex.
Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.
Surrey et al., London, United Kingdom. In Nat Cell Biol, 2014
Using a total internal reflection fluorescence microscopy-based reconstitution assay, we found that a hierarchical recruitment mode targets the large dynactin subunit p150Glued to growing microtubule ends via EB1 and CLIP-170 in the presence of competing SxIP-motif-containing peptides.
Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks.
Kapoor et al., New York City, United States. In Cell, 2014
Here, we combine optical trapping with TIRF-based microscopy to measure the force dependence of microtubule interaction for three nonmotor MAPs (NuMA, PRC1, and EB1) required for cell division.
RP1 and retinitis pigmentosa: report of novel mutations and insight into mutational mechanism.
Alkuraya et al., London, United Kingdom. In Br J Ophthalmol, 2012
The distribution of these novel and previously reported RP1 mutations makes it challenging to describe a unifying mutational mechanism for dominant versus recessive RP1-related retinitis pigmentosa.
Tyrosine-dependent capture of CAP-Gly domain-containing proteins in complex mixture by EB1 C-terminal peptidic probes.
Verdier-Pinard et al., Saint-Jean-de-la-Ruelle, France. In J Proteomics, 2012
We further demonstrate that this binding was prevented when the C-terminal tyrosine of EB1 was absent in the peptidic probes.
Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
Wittmann et al., San Francisco, United States. In J Biol Chem, 2012
Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).
Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.
Wilson et al., Santa Barbara, United States. In Biochemistry, 2012
results suggest that EB1 and ClipCG12 act cooperatively to regulate microtubule dynamics (EB1)
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women.
Hanash et al., Seattle, United States. In Cancer Prev Res (phila), 2012
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 precede a diagnosis of colorectal cancer in women
More papers using EB1 antibodies
Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3β in migrating epithelial cells
Waterman-Storer Clare M. et al., In The Journal of Cell Biology, 2000
... Monoclonal EB1 antibody was purchased from BD Biosciences.
FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle
Fang Guowei et al., In The Journal of Cell Biology, 2000
... Corporation); anti-GFP clone 3E6 (Invitrogen); anti–γ-tubulin clone GTU-88 (Sigma-Aldrich); CREST (Antibodies, Inc.); anti-Hec1 (GeneTex, Inc.); EB1 (BD Biosciences); and anti-p38MAPK, anti-Hsp70, and ...
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