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Early growth response 2

Early Growth Response Protein 2, EGR2, Krox-20
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: Egr-1, MPP, CAN, Fos, Cx32
Papers using Early Growth Response Protein 2 antibodies
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.
Tailleux Ludovic, In PLoS ONE, 2005
... To generate Egr-2 transgenic mice, the Egr-2 coding ...
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs
Lanyon Lance E. et al., In The Journal of Biological Chemistry, 2004
... EGR2 antibody was purchased from Santa Cruz Biotechnology (La Jolla, CA) ...
Papers on Early Growth Response Protein 2
Hepatic miR-126 is a Potential Plasma Biomarker for Detection of Hepatitis B Virus Infected Hepatocellular Carcinoma.
Banerjee et al., Calcutta, India. In Int J Cancer, Feb 2016
To understand the physiological role of these two miRNAs in hepato-carcinogenesis, target genes related to cancer pathways (APAF1, APC2, CDKN2A, IRS1, CRKL, LIFR, EGR2) were verified.
"Reverse genomics" predicts function of human conserved non-coding elements.
Bejerano et al., Stanford, United States. In Mol Biol Evol, Feb 2016
We discuss multiple CNEs, including a predicted ear element near BMP7, a pelvic CNE in FBN1, a brain morphology element in UBE4B, and an aquatic adaptation forelimb CNE near EGR2, and provide a full list of our predictions.
Glyphosate induces neurotoxicity in zebrafish.
Ochs et al., Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
However, we do not detect changes in hindbrain expression domains of ephA4 nor exclusive hindbrain markers krox-20 and hoxb1a.
MiRNAs and piRNAs from bone marrow mesenchymal stem cell extracellular vesicles induce cell survival and inhibit cell differentiation of cord blood hematopoietic stem cells: a new insight in transplantation.
Musto et al., Italy. In Oncotarget, Jan 2016
miR-27b/MPL, miR-21/ANXA1, miR-181/EGR2), indicating that EV content was able to modify gene expression profile of receiving cells.
Analysis of the zebrafish sox9b promoter: Identification of elements that recapitulate organ-specific expression of sox9b.
Heideman et al., Madison, United States. In Gene, Jan 2016
The 2.5kb region 5' of the sox9b contained 7 conserved non-coding elements (CNEs) that included putative hypoxia inducible factor 1α (HIF1α), CAAT box (CCAAT), early growth response protein 2 (EGR2), and core promoter elements.
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.
Delattre et al., Paris, France. In Nat Genet, Sep 2015
A recent genome-wide association study identified susceptibility variants near EGR2.
The transcriptional programs of iNKT cells.
Brenner et al., Boston, United States. In Semin Immunol, Feb 2015
The transcription factors EGR2 and PLZF (and microRNA like miR-150) are key regulators of the iNKT cell transcriptome during development.
WWP2: a multifunctional ubiquitin ligase gene.
Luo et al., Nanchong, China. In Pathol Oncol Res, 2014
WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so.
Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome identifies two new susceptibility loci at 1p31.2 and 10q21.3.
Yang et al., Chongqing, China. In Nat Genet, 2014
ADO-ZNF365-EGR2, rs442309, P(combined) = 2.97 × 10(-11), OR = 1.37; and HLA-DRB1/DQA1, rs3021304, P(combined) = 1.26 × 10(-118), OR = 2.97).
Autosomal recessive Charcot-Marie-Tooth disease: from genes to phenotypes.
Vallat et al., Algiers, Algeria. In J Peripher Nerv Syst, 2013
Recent clinical, morphological and molecular investigations of CMT families with autosomal recessive inheritance allowed the identification of many genes such as GDAP1, MTMR2, SBF2, NDRG1, EGR2, SH3TC2, PRX, FGD4, and FIG4, implicated in demyelinating forms (ARCMT1 or CMT4), and LMNA, MED25, HINT1, GDAP1, LRSAM1, NEFL, HSPB1 and MFN2 in axonal forms (ARCMT2).
Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination.
Almazan et al., Montréal, Canada. In Glia, 2012
our results show that p38 primarily directs Schwann cell differentiation and peripheral myelination by regulating Krox-20 expression through its downstream effectors, MK2 and MSK-1/CREB, and transcription factors SCIP and Sox10.
A novel EGR2 mutation within a family with a mild demyelinating form of Charcot-Marie-Tooth disease.
Nakagawa et al., Kyoto, Japan. In J Peripher Nerv Syst, 2012
we report on a heterozygous mutation in EGR2 in a family with a mild demyelinating form of adult-onset Charcot-Marie-Tooth disease
Homozygous deletion of an EGR2 enhancer in congenital amyelinating neuropathy.
Vallat et al., Limoges, France. In Ann Neurol, 2012
data further demonstrate the major role of the myelinating Schwann cell element in the regulation of EGR2 expression in the human peripheral nervous system
Roles of LAG3 and EGR2 in regulatory T cells.
Yamamoto et al., Tokyo, Japan. In Ann Rheum Dis, 2012
It has been found recently that IL-10-secreting iTregs can be delineated as CD4(+)CD25(-)Foxp3(-) T cells that characteristically express both the lymphocyte activation gene-3 (LAG3) and the early growth response gene-2 (EGR2).
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Delattre et al., Paris, France. In Nat Genet, 2012
Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.
Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU.
Song et al., Taejŏn, South Korea. In Korean J Parasitol, 2012
Expression of ALDH1A2, BEX2, EGR2, CCL3 and PLAU are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.
[Genetic diagnosis and molecular pathology of inherited neuropathy].
Takashima, Kagoshima, Japan. In Rinsho Shinkeigaku, 2011
We have been screening CMT patients for mutations using originally designed microarray DNA chips since 2007, thencehaving identified disease causing mutations in MPZ, GJB1, PMP22, EGR2, MFN2, NEFL, PRX, AARS, GARS, DNM2, and SETX genes in CMT patients.
A G protein-coupled receptor is essential for Schwann cells to initiate myelination.
Talbot et al., Stanford, United States. In Science, 2009
Axonal signals activate expression of specific transcription factors, including Oct6 and Krox20, that initiate myelination in Schwann cells.
Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies.
Lupski et al., Houston, United States. In Nat Genet, 1998
The early growth response 2 gene (EGR2) is part of a multigene family encoding Cys2His2 type zinc-finger proteins and may play a role in the regulation of cellular proliferation.
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