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Solute carrier family 1

EAAT4, Excitatory Amino Acid Transporter 4
mediates cotransport of one glutamate molecule with three Na+ ions and one H+ with countertransport of one K+ ion; also has a voltage gated anion transporter activity that is modified by glutamate [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, AGE, PCS, V1a
Papers on EAAT4
1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells.
Welsh et al., Albany, United States. In Mol Cell Endocrinol, Feb 2016
Under the same conditions, the expression of two other glutamate transporters - SLC1A6 (EAAT4) and SLC1A2 (EAAT2 or GLT-1) - is enhanced by 1,25D while that of SLC1A3 (EAAT1 or GLAST) and SLC7A11 (xCT) is decreased.
Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4.
Lang et al., Tübingen, Germany. In J Membr Biol, Jan 2016
UNASSIGNED: Excitatory amino acid transporters EAAT1 (SLC1A3), EAAT2 (SLC1A2), EAAT3 (SLC1A1), and EAAT4 (SLC1A6) serve to clear L-glutamate from the synaptic cleft and are thus important for the limitation of neuronal excitation.
Downregulation of Glutamate Transporter EAAT4 by Conditional Knockout of Rheb1 in Cerebellar Purkinje Cells.
Shen et al., Ningbo, China. In Cerebellum, Aug 2015
UNASSIGNED: Excitatory amino acid transporter 4 (EAAT4) is believed to be critical to the synaptic activity of cerebellar Purkinje cells by limiting extracellular glutamate concentrations and facilitating the induction of long-term depression.
Mechanisms of anion conduction by coupled glutamate transporters.
Fahlke et al., Jülich, Germany. In Cell, Mar 2015
Fluorescence quenching of inserted tryptophan residues indicated the entry of anions into this pathway, and mutations of homologous pore-forming residues had analogous effects on GltPh simulations and EAAT2/EAAT4 measurements of single-channel currents and anion/cation selectivities.
Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice.
Masocha, Kuwait, Kuwait. In Peerj, 2014
The 6 glutamate transporters (GLAST, GLT-1 EAAC1, EAAT4, VGLUT-1 and VGLUT-2) quantified were not significantly altered by paclitaxel treatment.
Regulation of cellular transport by klotho protein.
Dermaku-Sopjani et al., Pristina, Serbia. In Curr Protein Pept Sci, 2013
Klotho regulates diverse calcium and potassium ion channels, as well as several carriers including the Na(+)-coupled excitatory amino acid transporters EAAT3 and EAAT4, the Na(+)-coupled phosphate cotransporters, NaPi-IIa and NaPi-IIb, and a Na(+)/K(+)-ATPase.
Functional contributions of glutamate transporters at the parallel fibre to Purkinje neuron synapse-relevance for the progression of cerebellar ataxia.
Empson et al., Dunedin, New Zealand. In Cerebellum Ataxias, 2013
Two of these transporters, EAAT4 in Purkinje neurons (PN) and EAAT1 in Bergmann glia are both enriched within the cerebellum and altered in a variety of human ataxias.
Molecular identification and cellular localization of a potential transport system involved in cystine/cysteine uptake in human lenses.
Donaldson et al., Auckland, New Zealand. In Exp Eye Res, 2013
Using a combination of reverse transcriptase PCR, Western blotting and immunohistochemistry, we show that the light chain subunit of the cystine/glutamate exchanger (XC-), xCT, and members of the glutamate transporter family (XAG) which include the Excitatory Amino Acid Transporter 4 (EAAT4) and the Alanine Serine Cysteine Transporter 2 (ASCT2) are all present at the transcript and protein level in human lenses.
SLC1 glutamate transporters and diseases: psychiatric diseases and pathological pain.
Kaneko et al., Kyoto, Japan. In Curr Mol Pharmacol, 2013
The solute carrier family 1 (SLC1) consists of two neutral amino acid transporters and five high-affinity excitatory amino acid transporters (EAAT1-5).
The SLC1 high-affinity glutamate and neutral amino acid transporter family.
Hediger et al., Suita, Japan. In Mol Aspects Med, 2013
The high-affinity glutamate transporters EAAC1 (SLC1A1), GLT1 (SLC1A2), GLAST (SLC1A3), EAAT4 (SLC1A6), and EAAT5 (SLC1A7) mediate the cellular uptake of glutamate by the co-transport of three sodium ions (Na(+)) and one proton (H(+)), with the counter-transport of one potassium ion (K(+)).
GABA and Glutamate Transporters in Brain.
Danbolt et al., Oslo, Norway. In Front Endocrinol (lausanne), 2012
The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7).
Neuronal glutamate transporters regulate glial excitatory transmission.
Wadiche et al., Birmingham, United States. In J Neurosci, 2012
A twofold difference in functional EAAT4 levels is sufficient to alter signaling to Bergman glia in reporter mice.
Spinocerebellar ataxia type 5.
Ranum et al., Minneapolis, United States. In Handb Clin Neurol, 2011
TIRF microscopy performed on cell lines transiently transfected with mutant or wild-type spectrin shows that mutant β-III spectrin fails to stabilize the glutamate transporter EAAT4 at the plasma membrane.
Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4.
Fahlke et al., Hannover, Germany. In J Biol Chem, 2011
strate-dependent gating of anion channels associated with excitatory amino acid transporter 4.
Hetero-oligomerization of neuronal glutamate transporters.
Fahlke et al., Hannover, Germany. In J Biol Chem, 2011
EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3
Glutamate transporter EAAT4 in Purkinje cells controls intersynaptic diffusion of climbing fiber transmitter mediating inhibition of GABA release from interneurons.
Imoto et al., Okazaki, Japan. In Eur J Neurosci, 2010
Data demonstrate that the neuronal glutamate transporter EAAT4 in Purkinje cells plays a critical role in the extrasynaptic diffusion of climbing fiber transmitters.
A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4).
Fahlke et al., Hannover, Germany. In J Biol Chem, 2010
a conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4)
Spectrin mutations cause spinocerebellar ataxia type 5.
Ranum et al., Minneapolis, United States. In Nat Genet, 2006
Beta-III spectrin is highly expressed in Purkinje cells and has been shown to stabilize the glutamate transporter EAAT4 at the surface of the plasma membrane.
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.
Rothstein et al., Baltimore, United States. In Nature, 2001
To date, five distinct glutamate transporters have been cloned from animal and human tissue: GLAST (EAAT1), GLT-1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5 (refs 1-5).
An excitatory amino-acid transporter with properties of a ligand-gated chloride channel.
Amara et al., Portland, United States. In Nature, 1995
Here we report the cloning of a novel human aspartate/glutamate transporter, EAAT4, which is expressed predominantly in the cerebellum.
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