GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Nuclear factor, interleukin 3 regulated
E4BP4, NFIL3
Expression of interleukin-3 (IL3; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995 [PubMed 7565758]).[supplied by OMIM, Feb 2009] (from
NCBI)
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Top mentioned proteins:
CLOCK, CAN, HAD, E4, Dbp
Papers on
E4BP4
Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody.
New
Aurora, United States. In J Immunol, Dec 2015
Kidney trNK cells developed independent of NFIL3 and T-bet, and they expressed a distinct cell surface phenotype as compared with cNK cells.
[Identification of single nucleotide polymorphisms in centenarians].
New
Valencia, Spain. In Rev Esp Geriatr Gerontol, Dec 2015
where 5 of these (DACH1, LOC91948, BTB16, NFIL3 y HDAC4) have regulatory functions of the expressions of others genes.
Composition, Development, and Function of Uterine Innate Lymphoid Cells.
New
Cambridge, United Kingdom. In J Immunol, Nov 2015
Development of mouse uILC3 is Nfil3 independent, suggesting unique features of uILCs.
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
New
Impact
Buenos Aires, Argentina. In Cell, Oct 2015
Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α.
Deciphering the transcriptional switches of innate lymphoid cell programming: the right factors at the right time.
Review
New
Cambridge, United Kingdom. In Genes Immun, Apr 2015
Notch, GATA-3 (GATA-binding protein 3), Nfil3 (nuclear factor interleukin-3) and Id2 (inhibitor of DNA-binding 2) are identified as early factors that suppress B- and T-cell potentials and are turned on in favour of ILC commitment.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Impact
Boston, United States. In Nat Immunol, 2015
Unlike other iNKT cells, they lacked PLZF but expressed the transcription factor E4BP4, which controlled their IL-10 production.
Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows.
Urbana, United States. In Plos One, 2014
In experiment 2, cows in control (CON) or receiving 50 g/d of L-carnitine (C50) from -14 through 21 d had increased FGF21, PPARA, and NFIL3 on d 10 compared with d 2 postpartum.
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Review
Bethesda, United States. In Mediators Inflamm, 2014
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.
Impact
Düsseldorf, Germany. In Immunity, 2014
Consequently, T cell immunity of IFN-I receptor (IFNAR)-deficient T cells could be restored by NK cell depletion or in NK-cell-deficient hosts (Nfil3(-/-)).
New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond.
Edinburg, United States. In Discoveries (craiova), 2014
UNASSIGNED: The bZIP transcription factor NFIL3 (Nuclear factor Interleukin 3 regulated, also known as E4 binding protein 4, E4BP4) regulates diverse biological processes from circadian rhythm to cellular viability.
[The role of IL-10 in the modulation of the immune response in normal conditions and the tumor environment].
Review
In Postepy Hig Med Dosw (online), 2013
Under the influence of the various stimuli that activate transcription factors such as cMaf, NFIL3, and ERK, many normal and neoplastic cells are able to produce the same cytokine--IL-10.
TH17 cell differentiation is regulated by the circadian clock.
Impact
Dallas, United States. In Science, 2013
We show that the transcription factor NFIL3 suppresses T(H)17 cell development by directly binding and repressing the Rorγt promoter.
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.
Impact
Saint Louis, United States. In Immunity, 2013
In mice, intraepithelial ILC1 were distinguished by CD160 expression and required Nfil3- and Tbx21-encoded transcription factors for development, but not IL-15 receptor-α, indicating that intraepithelial ILC1 are distinct from conventional NK cells.
Terminal differentiation of dendritic cells.
Review
Melbourne, Australia. In Adv Immunol, 2012
Several transcription factors such as Batf3, Nfil3, and Id2 are required for different DC subsets at steady-state and drive segregation into the individual DCs subsets late in development in the CD8 lineage.
PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
GeneRIF
Montréal, Canada. In J Cell Physiol, 2012
PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
E4BP4: an unexpected player in the immune response.
Review
London, United Kingdom. In Trends Immunol, 2012
Until recently, the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) was of little interest to immunologists, being best known for its role in regulating circadian rhythm in chick pineal gland.
Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator.
GeneRIF
Tsukuba, Japan. In Febs Lett, 2011
Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP.
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
GeneRIF
Memphis, United States. In J Biol Chem, 2011
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.
GeneRIF
Iowa City, United States. In Blood, 2011
NFIL3 plays an essential role in the development of CD8alpha(+) cDCs.
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
GeneRIF
Iowa City, United States. In Embo J, 2011
Taken together, these data indicate that NFIL3 is a key regulator of T(H)2 cytokine expression.
